Intrahippocampal injection of pertussis toxin blocks adenosine suppression of synaptic responses
Adenosine exerts prominent inhibitory effects on synaptic transmission via a presynaptic action. Using the hippocampal slice preparation, we have found in electrophysiological experiments that this action of adenosine is blocked by intrahippocampal injections of pertussis toxin. In biochemical studi...
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| Veröffentlicht in: | Brain research 1989-08, Vol.494 (2), p.359-364 |
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| container_end_page | 364 |
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| container_issue | 2 |
| container_start_page | 359 |
| container_title | Brain research |
| container_volume | 494 |
| creator | Stratton, Kathleen R. Cole, Andrew J. Pritchett, John Eccles, Christine U. Worley, Paul F. Baraban, Jay M. |
| description | Adenosine exerts prominent inhibitory effects on synaptic transmission via a presynaptic action. Using the hippocampal slice preparation, we have found in electrophysiological experiments that this action of adenosine is blocked by intrahippocampal injections of pertussis toxin. In biochemical studies, we have confirmed that this treatment affects the GTP-binding proteins, G
i and G
o, in this preparation. These results indicate that both pre- and postsynaptic actions of adenosine involve pertussis toxin-sensitive GTP-binding proteins. |
| doi_str_mv | 10.1016/0006-8993(89)90604-5 |
| format | Article |
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i and G
o, in this preparation. These results indicate that both pre- and postsynaptic actions of adenosine involve pertussis toxin-sensitive GTP-binding proteins.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(89)90604-5</identifier><identifier>PMID: 2505887</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Action Potentials - drug effects ; Adenosine ; Adenosine - pharmacology ; Animals ; Biological and medical sciences ; Caffeine ; Central nervous system ; Clostridium tetani ; Electrophysiology ; Fundamental and applied biological sciences. Psychology ; GTP-Binding Proteins - metabolism ; Guanosine triphosphate-binding protein ; Hippocampus ; Hippocampus - drug effects ; Hippocampus - physiology ; Male ; Pertussis Toxin ; Rats ; Rats, Inbred Strains ; Vertebrates: nervous system and sense organs ; Virulence Factors, Bordetella - pharmacology</subject><ispartof>Brain research, 1989-08, Vol.494 (2), p.359-364</ispartof><rights>1989 Elsevier Science Publishers B.V. (Biomedical Division)</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-903ca5ad58bb1298cd966086079e90eee45afc72a8b2951c4af1031f1068fb823</citedby><cites>FETCH-LOGICAL-c417t-903ca5ad58bb1298cd966086079e90eee45afc72a8b2951c4af1031f1068fb823</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0006899389906045$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6819782$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2505887$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stratton, Kathleen R.</creatorcontrib><creatorcontrib>Cole, Andrew J.</creatorcontrib><creatorcontrib>Pritchett, John</creatorcontrib><creatorcontrib>Eccles, Christine U.</creatorcontrib><creatorcontrib>Worley, Paul F.</creatorcontrib><creatorcontrib>Baraban, Jay M.</creatorcontrib><title>Intrahippocampal injection of pertussis toxin blocks adenosine suppression of synaptic responses</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>Adenosine exerts prominent inhibitory effects on synaptic transmission via a presynaptic action. Using the hippocampal slice preparation, we have found in electrophysiological experiments that this action of adenosine is blocked by intrahippocampal injections of pertussis toxin. In biochemical studies, we have confirmed that this treatment affects the GTP-binding proteins, G
i and G
o, in this preparation. These results indicate that both pre- and postsynaptic actions of adenosine involve pertussis toxin-sensitive GTP-binding proteins.</description><subject>Action Potentials - drug effects</subject><subject>Adenosine</subject><subject>Adenosine - pharmacology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Caffeine</subject><subject>Central nervous system</subject><subject>Clostridium tetani</subject><subject>Electrophysiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GTP-Binding Proteins - metabolism</subject><subject>Guanosine triphosphate-binding protein</subject><subject>Hippocampus</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - physiology</subject><subject>Male</subject><subject>Pertussis Toxin</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>Virulence Factors, Bordetella - pharmacology</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi1EVbaFfwBSDgiVQ8o4iR37UglVfFSq1Es5G8eZCJesbTwJov8eb3e1R7jMaDzPjMbvy9hrDpccuPwAALJWWrcXSr_XIKGrxTO24apvatl08JxtjsgLdkb0UMq21XDKThsBQql-w77fhCXbHz6l6Ow22bny4QHd4mOo4lQlzMtK5Kla4h8fqmGO7idVdsQQyQesaE0pYyH2PD0GmxbvqvKWYiCkl-xksjPhq0M-Z98-f7q__lrf3n25uf54W7uO90utoXVW2FGoYeCNVm7UUoKS0GvUgIidsJPrG6uGRgvuOjtxaHkJUk2Datpz9m6_N-X4a0VazNaTw3m2AeNKptdcA2_lf0Eu2mZHFrDbgy5HooyTSdlvbX40HMzOAbOT1-zkLcE8OWBEGXtz2L8OWxyPQwfJS__toW_J2XnKNjhPR0wqrvun_1ztMSyi_faYDTmPweHoc_HHjNH_-46_UxOjog</recordid><startdate>19890814</startdate><enddate>19890814</enddate><creator>Stratton, Kathleen R.</creator><creator>Cole, Andrew J.</creator><creator>Pritchett, John</creator><creator>Eccles, Christine U.</creator><creator>Worley, Paul F.</creator><creator>Baraban, Jay M.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19890814</creationdate><title>Intrahippocampal injection of pertussis toxin blocks adenosine suppression of synaptic responses</title><author>Stratton, Kathleen R. ; Cole, Andrew J. ; Pritchett, John ; Eccles, Christine U. ; Worley, Paul F. ; Baraban, Jay M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-903ca5ad58bb1298cd966086079e90eee45afc72a8b2951c4af1031f1068fb823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Action Potentials - drug effects</topic><topic>Adenosine</topic><topic>Adenosine - pharmacology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Caffeine</topic><topic>Central nervous system</topic><topic>Clostridium tetani</topic><topic>Electrophysiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>GTP-Binding Proteins - metabolism</topic><topic>Guanosine triphosphate-binding protein</topic><topic>Hippocampus</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - physiology</topic><topic>Male</topic><topic>Pertussis Toxin</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>Virulence Factors, Bordetella - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stratton, Kathleen R.</creatorcontrib><creatorcontrib>Cole, Andrew J.</creatorcontrib><creatorcontrib>Pritchett, John</creatorcontrib><creatorcontrib>Eccles, Christine U.</creatorcontrib><creatorcontrib>Worley, Paul F.</creatorcontrib><creatorcontrib>Baraban, Jay M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stratton, Kathleen R.</au><au>Cole, Andrew J.</au><au>Pritchett, John</au><au>Eccles, Christine U.</au><au>Worley, Paul F.</au><au>Baraban, Jay M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intrahippocampal injection of pertussis toxin blocks adenosine suppression of synaptic responses</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1989-08-14</date><risdate>1989</risdate><volume>494</volume><issue>2</issue><spage>359</spage><epage>364</epage><pages>359-364</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>Adenosine exerts prominent inhibitory effects on synaptic transmission via a presynaptic action. Using the hippocampal slice preparation, we have found in electrophysiological experiments that this action of adenosine is blocked by intrahippocampal injections of pertussis toxin. In biochemical studies, we have confirmed that this treatment affects the GTP-binding proteins, G
i and G
o, in this preparation. These results indicate that both pre- and postsynaptic actions of adenosine involve pertussis toxin-sensitive GTP-binding proteins.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>2505887</pmid><doi>10.1016/0006-8993(89)90604-5</doi><tpages>6</tpages></addata></record> |
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| ispartof | Brain research, 1989-08, Vol.494 (2), p.359-364 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Action Potentials - drug effects Adenosine Adenosine - pharmacology Animals Biological and medical sciences Caffeine Central nervous system Clostridium tetani Electrophysiology Fundamental and applied biological sciences. Psychology GTP-Binding Proteins - metabolism Guanosine triphosphate-binding protein Hippocampus Hippocampus - drug effects Hippocampus - physiology Male Pertussis Toxin Rats Rats, Inbred Strains Vertebrates: nervous system and sense organs Virulence Factors, Bordetella - pharmacology |
| title | Intrahippocampal injection of pertussis toxin blocks adenosine suppression of synaptic responses |
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