Bacterial infection ( [formula omitted]) stimulates fever, metabolic rate and brown adipose tissue activity in the Guinea pig
The objective of this study was to assess whether bacterial infection stimulates oxygen consumption and brown adipose tissue (BAT) activity. Guinea pigs infected with Legionella pneumophila showed marked fever and a significant (33%) increase in resting oxygen consumption (VO 2), 24th after infectio...
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| Veröffentlicht in: | Life sciences (1973) 1989, Vol.45 (9), p.843-847 |
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| container_title | Life sciences (1973) |
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| creator | Cooper, A.L. Fitzgeorge, R.B. Baskerville, A. Little, R.A. Rothwell, N.J. |
| description | The objective of this study was to assess whether bacterial infection stimulates oxygen consumption and brown adipose tissue (BAT) activity. Guinea pigs infected with
Legionella pneumophila
showed marked fever and a significant (33%) increase in resting oxygen consumption (VO
2), 24th after infection. At this time, food intake and body weight were normal and the
in vitro
thermogenic activity of BAT taken from infected animals was elevated by 64% above that of control guinea pigs. VO
2 and BAT activity fell to control values by 48h as infected animals became moribund and over this period food intake was markedly reduced.
Bacterial infection is frequently associated with fever, which is generated by both increased heat production and reduced heat loss. Hypermetabolic responses to infection and injury may involve similar mechanisms to non-shivering thermogenesis (1,2,3). Studies on laboratory rodents have tended to concentrate on the use of bacterial endotoxins (eg 2), which do not mimic all aspects of the responses to infection, particularly since they are short-lived and are rapidly tolerated. We report here the results of a study using a pneumonia infection with
Legionella pneumophila
in the guinea pig. The objective of the study was to determine whether bacterial infection which causes weight loss is associated with hypermetabolism and activation of BAT. |
| doi_str_mv | 10.1016/0024-3205(89)90178-1 |
| format | Article |
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Legionella pneumophila
showed marked fever and a significant (33%) increase in resting oxygen consumption (VO
2), 24th after infection. At this time, food intake and body weight were normal and the
in vitro
thermogenic activity of BAT taken from infected animals was elevated by 64% above that of control guinea pigs. VO
2 and BAT activity fell to control values by 48h as infected animals became moribund and over this period food intake was markedly reduced.
Bacterial infection is frequently associated with fever, which is generated by both increased heat production and reduced heat loss. Hypermetabolic responses to infection and injury may involve similar mechanisms to non-shivering thermogenesis (1,2,3). Studies on laboratory rodents have tended to concentrate on the use of bacterial endotoxins (eg 2), which do not mimic all aspects of the responses to infection, particularly since they are short-lived and are rapidly tolerated. We report here the results of a study using a pneumonia infection with
Legionella pneumophila
in the guinea pig. The objective of the study was to determine whether bacterial infection which causes weight loss is associated with hypermetabolism and activation of BAT.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/0024-3205(89)90178-1</identifier><identifier>PMID: 2770424</identifier><identifier>CODEN: LIFSAK</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Adipose Tissue - metabolism ; Adipose Tissue, Brown - metabolism ; Animals ; Bacterial diseases ; Biological and medical sciences ; Disease Models, Animal ; Drinking ; Eating ; Experimental bacterial diseases and models ; Female ; Fever ; Guinea Pigs ; Infectious diseases ; Legionnaires' Disease - metabolism ; Medical sciences ; Oxygen Consumption ; Weight Loss</subject><ispartof>Life sciences (1973), 1989, Vol.45 (9), p.843-847</ispartof><rights>1989</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-291a0d2163b78fb45dfdb5af555f5297b284f221a447d81b57c037c8e49354103</citedby><cites>FETCH-LOGICAL-c417t-291a0d2163b78fb45dfdb5af555f5297b284f221a447d81b57c037c8e49354103</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0024-3205(89)90178-1$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,4022,27922,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6606149$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2770424$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cooper, A.L.</creatorcontrib><creatorcontrib>Fitzgeorge, R.B.</creatorcontrib><creatorcontrib>Baskerville, A.</creatorcontrib><creatorcontrib>Little, R.A.</creatorcontrib><creatorcontrib>Rothwell, N.J.</creatorcontrib><title>Bacterial infection ( [formula omitted]) stimulates fever, metabolic rate and brown adipose tissue activity in the Guinea pig</title><title>Life sciences (1973)</title><addtitle>Life Sci</addtitle><description>The objective of this study was to assess whether bacterial infection stimulates oxygen consumption and brown adipose tissue (BAT) activity. Guinea pigs infected with
Legionella pneumophila
showed marked fever and a significant (33%) increase in resting oxygen consumption (VO
2), 24th after infection. At this time, food intake and body weight were normal and the
in vitro
thermogenic activity of BAT taken from infected animals was elevated by 64% above that of control guinea pigs. VO
2 and BAT activity fell to control values by 48h as infected animals became moribund and over this period food intake was markedly reduced.
Bacterial infection is frequently associated with fever, which is generated by both increased heat production and reduced heat loss. Hypermetabolic responses to infection and injury may involve similar mechanisms to non-shivering thermogenesis (1,2,3). Studies on laboratory rodents have tended to concentrate on the use of bacterial endotoxins (eg 2), which do not mimic all aspects of the responses to infection, particularly since they are short-lived and are rapidly tolerated. We report here the results of a study using a pneumonia infection with
Legionella pneumophila
in the guinea pig. The objective of the study was to determine whether bacterial infection which causes weight loss is associated with hypermetabolism and activation of BAT.</description><subject>Adipose Tissue - metabolism</subject><subject>Adipose Tissue, Brown - metabolism</subject><subject>Animals</subject><subject>Bacterial diseases</subject><subject>Biological and medical sciences</subject><subject>Disease Models, Animal</subject><subject>Drinking</subject><subject>Eating</subject><subject>Experimental bacterial diseases and models</subject><subject>Female</subject><subject>Fever</subject><subject>Guinea Pigs</subject><subject>Infectious diseases</subject><subject>Legionnaires' Disease - metabolism</subject><subject>Medical sciences</subject><subject>Oxygen Consumption</subject><subject>Weight Loss</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUGPFCEUhInRrOvoP9CEgzG7ia1AQwMXE93oarKJFz0ZQ2h4KKa7GYEeswf_u4wzmaOeSF59r4AqhB5T8oISOrwkhPGuZ0RcKH2pCZWqo3fQOVVSd2To6V10fkLuowel_CCECCH7M3TGpCSc8XP0-411FXK0E45LAFdjWvAF_hJSntfJ4jTHWsF_vcSlxv2kQsEBdpCf4xmqHdMUHc5tjO3i8ZjTrwVbH7epAK6xlLUJzXUX6227AdfvgK_XuIDF2_jtIboX7FTg0fHcoM_v3n66et_dfLz-cPX6pnOcytoxTS3xjA79KFUYufDBj8IGIUQQTMuRKR4Yo5Zz6RUdhXSkl04B173glPQb9Ozgu83p5wqlmjkWB9NkF0hrMVJTpYXu_wtS0UuulGggP4Aup1IyBLPNcbb51lBi9vWYffZmn71R2vytx9C29uTov44z-NPSsY-mPz3qtjg7hWwXF8sJGwYy0PapDXp1wKCFtouQTXERFgc-5tah8Sn--x1_ACo_q4w</recordid><startdate>1989</startdate><enddate>1989</enddate><creator>Cooper, A.L.</creator><creator>Fitzgeorge, R.B.</creator><creator>Baskerville, A.</creator><creator>Little, R.A.</creator><creator>Rothwell, N.J.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>1989</creationdate><title>Bacterial infection ( [formula omitted]) stimulates fever, metabolic rate and brown adipose tissue activity in the Guinea pig</title><author>Cooper, A.L. ; Fitzgeorge, R.B. ; Baskerville, A. ; Little, R.A. ; Rothwell, N.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-291a0d2163b78fb45dfdb5af555f5297b284f221a447d81b57c037c8e49354103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Adipose Tissue - metabolism</topic><topic>Adipose Tissue, Brown - metabolism</topic><topic>Animals</topic><topic>Bacterial diseases</topic><topic>Biological and medical sciences</topic><topic>Disease Models, Animal</topic><topic>Drinking</topic><topic>Eating</topic><topic>Experimental bacterial diseases and models</topic><topic>Female</topic><topic>Fever</topic><topic>Guinea Pigs</topic><topic>Infectious diseases</topic><topic>Legionnaires' Disease - metabolism</topic><topic>Medical sciences</topic><topic>Oxygen Consumption</topic><topic>Weight Loss</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cooper, A.L.</creatorcontrib><creatorcontrib>Fitzgeorge, R.B.</creatorcontrib><creatorcontrib>Baskerville, A.</creatorcontrib><creatorcontrib>Little, R.A.</creatorcontrib><creatorcontrib>Rothwell, N.J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cooper, A.L.</au><au>Fitzgeorge, R.B.</au><au>Baskerville, A.</au><au>Little, R.A.</au><au>Rothwell, N.J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bacterial infection ( [formula omitted]) stimulates fever, metabolic rate and brown adipose tissue activity in the Guinea pig</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>1989</date><risdate>1989</risdate><volume>45</volume><issue>9</issue><spage>843</spage><epage>847</epage><pages>843-847</pages><issn>0024-3205</issn><eissn>1879-0631</eissn><coden>LIFSAK</coden><abstract>The objective of this study was to assess whether bacterial infection stimulates oxygen consumption and brown adipose tissue (BAT) activity. Guinea pigs infected with
Legionella pneumophila
showed marked fever and a significant (33%) increase in resting oxygen consumption (VO
2), 24th after infection. At this time, food intake and body weight were normal and the
in vitro
thermogenic activity of BAT taken from infected animals was elevated by 64% above that of control guinea pigs. VO
2 and BAT activity fell to control values by 48h as infected animals became moribund and over this period food intake was markedly reduced.
Bacterial infection is frequently associated with fever, which is generated by both increased heat production and reduced heat loss. Hypermetabolic responses to infection and injury may involve similar mechanisms to non-shivering thermogenesis (1,2,3). Studies on laboratory rodents have tended to concentrate on the use of bacterial endotoxins (eg 2), which do not mimic all aspects of the responses to infection, particularly since they are short-lived and are rapidly tolerated. We report here the results of a study using a pneumonia infection with
Legionella pneumophila
in the guinea pig. The objective of the study was to determine whether bacterial infection which causes weight loss is associated with hypermetabolism and activation of BAT.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>2770424</pmid><doi>10.1016/0024-3205(89)90178-1</doi><tpages>5</tpages></addata></record> |
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| ispartof | Life sciences (1973), 1989, Vol.45 (9), p.843-847 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adipose Tissue - metabolism Adipose Tissue, Brown - metabolism Animals Bacterial diseases Biological and medical sciences Disease Models, Animal Drinking Eating Experimental bacterial diseases and models Female Fever Guinea Pigs Infectious diseases Legionnaires' Disease - metabolism Medical sciences Oxygen Consumption Weight Loss |
| title | Bacterial infection ( [formula omitted]) stimulates fever, metabolic rate and brown adipose tissue activity in the Guinea pig |
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