Sucralfate delays gastric emptying of liquids and solids in duodenal ulcer patients
Gastric emptying studies were performed on nine healthy volunteers and ten duodenal ulcer (DU) patients utilizing a dual radionuclide technique to assess simultaneously emptying rates of liquid ( 111In labeled water) and solid ( 99mTc sulfur colloid labeled chicken liver) components of a meal. One g...
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| Veröffentlicht in: | International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology Nuclear medicine and biology, 1989, Vol.16 (4), p.389,395-393,395 |
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| container_end_page | 393,395 |
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| container_issue | 4 |
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| container_title | International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology |
| container_volume | 16 |
| creator | Petersen, John M. Caride, Vicente J. Prokop, Edward K. Troncale, Frank J. McCallum, Richard W. |
| description | Gastric emptying studies were performed on nine healthy volunteers and ten duodenal ulcer (DU) patients utilizing a dual radionuclide technique to assess simultaneously emptying rates of liquid (
111In labeled water) and solid (
99mTc sulfur colloid labeled chicken liver) components of a meal. One gram of sucralfate was compared to placebo in separate days in a randomized double-blind crossover fashion. Subjects ingested the radiolabeled test meal 1 h after receiving medication, and gastric emptying was monitored for 3 h using a γ camera interfaced with a computer. We found that DU patients had significantly faster gastric emptying of solids (
P < 0.05) compared to normals on the placebo days, while liquid emptying rates were similar. Sucralfate, in the DU patients, significantly (
P < 0.05) slowed gastric emptying of water from 20 to 40 min and emptying of the solid component from 100–160 min after the meal compared to placebo. In normal subjects, gastric emptying of liquids and solids was not significantly affected by sucralfate.
We conclude that slowing of gastric emptying, possibly mediated through aluminum ions, occurs in DU patients on sucralfate. This may be one mechanism by which sucralfate enhances healing and decreases recurrence of duodenal ulcer. |
| doi_str_mv | 10.1016/0883-2897(89)90106-2 |
| format | Article |
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111In labeled water) and solid (
99mTc sulfur colloid labeled chicken liver) components of a meal. One gram of sucralfate was compared to placebo in separate days in a randomized double-blind crossover fashion. Subjects ingested the radiolabeled test meal 1 h after receiving medication, and gastric emptying was monitored for 3 h using a γ camera interfaced with a computer. We found that DU patients had significantly faster gastric emptying of solids (
P < 0.05) compared to normals on the placebo days, while liquid emptying rates were similar. Sucralfate, in the DU patients, significantly (
P < 0.05) slowed gastric emptying of water from 20 to 40 min and emptying of the solid component from 100–160 min after the meal compared to placebo. In normal subjects, gastric emptying of liquids and solids was not significantly affected by sucralfate.
We conclude that slowing of gastric emptying, possibly mediated through aluminum ions, occurs in DU patients on sucralfate. This may be one mechanism by which sucralfate enhances healing and decreases recurrence of duodenal ulcer.</description><identifier>ISSN: 0883-2897</identifier><identifier>ISSN: 0969-8051</identifier><identifier>EISSN: 1872-9614</identifier><identifier>DOI: 10.1016/0883-2897(89)90106-2</identifier><identifier>PMID: 2777580</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ltd</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Digestive system ; Double-Blind Method ; Duodenal Ulcer - diagnostic imaging ; Duodenal Ulcer - drug therapy ; Female ; Food ; Gastric Emptying - drug effects ; Humans ; Indium Radioisotopes ; Male ; Medical sciences ; Middle Aged ; Pharmacology. Drug treatments ; Radionuclide Imaging ; Random Allocation ; Sucralfate - therapeutic use ; Technetium Tc 99m Sulfur Colloid</subject><ispartof>International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology, 1989, Vol.16 (4), p.389,395-393,395</ispartof><rights>1989</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-599bd98e074207d08ec3d8062840063ba153a8b2aabad6a37a2c220cc596b6dc3</citedby><cites>FETCH-LOGICAL-c503t-599bd98e074207d08ec3d8062840063ba153a8b2aabad6a37a2c220cc596b6dc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19899838$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2777580$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Petersen, John M.</creatorcontrib><creatorcontrib>Caride, Vicente J.</creatorcontrib><creatorcontrib>Prokop, Edward K.</creatorcontrib><creatorcontrib>Troncale, Frank J.</creatorcontrib><creatorcontrib>McCallum, Richard W.</creatorcontrib><title>Sucralfate delays gastric emptying of liquids and solids in duodenal ulcer patients</title><title>International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology</title><addtitle>Int J Rad Appl Instrum B</addtitle><description>Gastric emptying studies were performed on nine healthy volunteers and ten duodenal ulcer (DU) patients utilizing a dual radionuclide technique to assess simultaneously emptying rates of liquid (
111In labeled water) and solid (
99mTc sulfur colloid labeled chicken liver) components of a meal. One gram of sucralfate was compared to placebo in separate days in a randomized double-blind crossover fashion. Subjects ingested the radiolabeled test meal 1 h after receiving medication, and gastric emptying was monitored for 3 h using a γ camera interfaced with a computer. We found that DU patients had significantly faster gastric emptying of solids (
P < 0.05) compared to normals on the placebo days, while liquid emptying rates were similar. Sucralfate, in the DU patients, significantly (
P < 0.05) slowed gastric emptying of water from 20 to 40 min and emptying of the solid component from 100–160 min after the meal compared to placebo. In normal subjects, gastric emptying of liquids and solids was not significantly affected by sucralfate.
We conclude that slowing of gastric emptying, possibly mediated through aluminum ions, occurs in DU patients on sucralfate. This may be one mechanism by which sucralfate enhances healing and decreases recurrence of duodenal ulcer.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Digestive system</subject><subject>Double-Blind Method</subject><subject>Duodenal Ulcer - diagnostic imaging</subject><subject>Duodenal Ulcer - drug therapy</subject><subject>Female</subject><subject>Food</subject><subject>Gastric Emptying - drug effects</subject><subject>Humans</subject><subject>Indium Radioisotopes</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Radionuclide Imaging</subject><subject>Random Allocation</subject><subject>Sucralfate - therapeutic use</subject><subject>Technetium Tc 99m Sulfur Colloid</subject><issn>0883-2897</issn><issn>0969-8051</issn><issn>1872-9614</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LJDEQhsPioqPuP1DIxUUPvVbSH0kuwjL4sSB4cD2H6qRGIpnuMekW5t_b4wx681QF9bwvxcPYiYA_AkRzCVqXhdRGnWtzYUBAU8gfbCa0koVpRLXHZp_IATvM-QVA6qpW-2xfKqVqDTP2-Di6hHGBA3FPEdeZP2MeUnCclqthHbpn3i94DK9j8Jlj53nu42YNHfdj76nDyMfoKPEVDoG6IR-znwuMmX7t5hF7urn-P78r7h9u_83_3heuhnIoamNabzSBqiQoD5pc6TU0048ATdmiqEvUrURs0TdYKpROSnCuNk3beFcesd_b3lXqX0fKg12G7ChG7Kgfs1VGaCOqegKrLehSn3OihV2lsMS0tgLsxqXdiLIbUVYb--HSyil2uusf2yX5z9BO3nQ_290xu8lhws6F_NVttDG61BN3teVokvEWKNnsJlGOfEjkBuv78P0j73iukKQ</recordid><startdate>1989</startdate><enddate>1989</enddate><creator>Petersen, John M.</creator><creator>Caride, Vicente J.</creator><creator>Prokop, Edward K.</creator><creator>Troncale, Frank J.</creator><creator>McCallum, Richard W.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1989</creationdate><title>Sucralfate delays gastric emptying of liquids and solids in duodenal ulcer patients</title><author>Petersen, John M. ; Caride, Vicente J. ; Prokop, Edward K. ; Troncale, Frank J. ; McCallum, Richard W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c503t-599bd98e074207d08ec3d8062840063ba153a8b2aabad6a37a2c220cc596b6dc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Digestive system</topic><topic>Double-Blind Method</topic><topic>Duodenal Ulcer - diagnostic imaging</topic><topic>Duodenal Ulcer - drug therapy</topic><topic>Female</topic><topic>Food</topic><topic>Gastric Emptying - drug effects</topic><topic>Humans</topic><topic>Indium Radioisotopes</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Radionuclide Imaging</topic><topic>Random Allocation</topic><topic>Sucralfate - therapeutic use</topic><topic>Technetium Tc 99m Sulfur Colloid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Petersen, John M.</creatorcontrib><creatorcontrib>Caride, Vicente J.</creatorcontrib><creatorcontrib>Prokop, Edward K.</creatorcontrib><creatorcontrib>Troncale, Frank J.</creatorcontrib><creatorcontrib>McCallum, Richard W.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of radiation applications and instrumentation. 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Part B, Nuclear medicine and biology</jtitle><addtitle>Int J Rad Appl Instrum B</addtitle><date>1989</date><risdate>1989</risdate><volume>16</volume><issue>4</issue><spage>389,395</spage><epage>393,395</epage><pages>389,395-393,395</pages><issn>0883-2897</issn><issn>0969-8051</issn><eissn>1872-9614</eissn><abstract>Gastric emptying studies were performed on nine healthy volunteers and ten duodenal ulcer (DU) patients utilizing a dual radionuclide technique to assess simultaneously emptying rates of liquid (
111In labeled water) and solid (
99mTc sulfur colloid labeled chicken liver) components of a meal. One gram of sucralfate was compared to placebo in separate days in a randomized double-blind crossover fashion. Subjects ingested the radiolabeled test meal 1 h after receiving medication, and gastric emptying was monitored for 3 h using a γ camera interfaced with a computer. We found that DU patients had significantly faster gastric emptying of solids (
P < 0.05) compared to normals on the placebo days, while liquid emptying rates were similar. Sucralfate, in the DU patients, significantly (
P < 0.05) slowed gastric emptying of water from 20 to 40 min and emptying of the solid component from 100–160 min after the meal compared to placebo. In normal subjects, gastric emptying of liquids and solids was not significantly affected by sucralfate.
We conclude that slowing of gastric emptying, possibly mediated through aluminum ions, occurs in DU patients on sucralfate. This may be one mechanism by which sucralfate enhances healing and decreases recurrence of duodenal ulcer.</abstract><cop>Amsterdam</cop><pub>Elsevier Ltd</pub><pmid>2777580</pmid><doi>10.1016/0883-2897(89)90106-2</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology, 1989, Vol.16 (4), p.389,395-393,395 |
| issn | 0883-2897 0969-8051 1872-9614 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adult Aged Biological and medical sciences Digestive system Double-Blind Method Duodenal Ulcer - diagnostic imaging Duodenal Ulcer - drug therapy Female Food Gastric Emptying - drug effects Humans Indium Radioisotopes Male Medical sciences Middle Aged Pharmacology. Drug treatments Radionuclide Imaging Random Allocation Sucralfate - therapeutic use Technetium Tc 99m Sulfur Colloid |
| title | Sucralfate delays gastric emptying of liquids and solids in duodenal ulcer patients |
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