Evaluation of L6, an anti-carcinoma murine monoclonal antibody, in tumor-bearing nude mice
L6 is a murine monoclonal antibody (MAb) binding to cells of most human carcinomas, mediating antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity, and inhibiting tumor growth in nude mice [10]. Fab and F(ab')2 fragments of L6, as well as intact MAb, have been evaluate...
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| Veröffentlicht in: | Radiotherapy and oncology 1989-07, Vol.15 (3), p.295-305 |
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| creator | Lavie, E Beaumier, P L Brodzinsky, L Hellström, K E Hellström, I |
| description | L6 is a murine monoclonal antibody (MAb) binding to cells of most human carcinomas, mediating antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity, and inhibiting tumor growth in nude mice [10]. Fab and F(ab')2 fragments of L6, as well as intact MAb, have been evaluated for immunospecific localization in nude mice xenografted with a human lung carcinoma. They were compared with preparations of an isotype-matched control immunoglobulin, P1.17, after labelling with 125I or 131I. L6 Fab fragments prepared from MAb L6 and labelled with 67Ga via desferrioxamine were also tested. The data suggest that MAb L6 may be useful for in vivo detection of human carcinomas. |
| doi_str_mv | 10.1016/0167-8140(89)90098-4 |
| format | Article |
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Fab and F(ab')2 fragments of L6, as well as intact MAb, have been evaluated for immunospecific localization in nude mice xenografted with a human lung carcinoma. They were compared with preparations of an isotype-matched control immunoglobulin, P1.17, after labelling with 125I or 131I. L6 Fab fragments prepared from MAb L6 and labelled with 67Ga via desferrioxamine were also tested. 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The data suggest that MAb L6 may be useful for in vivo detection of human carcinomas.</description><subject>Animals</subject><subject>Antibodies, Monoclonal</subject><subject>Female</subject><subject>Gallium Radioisotopes</subject><subject>Immunoglobulin Fab Fragments</subject><subject>Iodine Radioisotopes</subject><subject>Metabolic Clearance Rate</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Nude</subject><subject>Neoplasm Transplantation</subject><subject>Neoplasms, Experimental - immunology</subject><subject>Neoplasms, Experimental - metabolism</subject><subject>Tissue Distribution</subject><issn>0167-8140</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMtKAzEUhrNQaq2-gUJWotDRXGZyWUqpFyi40Y2bkMkkEplJajIj9O07vVA4hwOH7_8XHwA3GD1ihNnTuLwQuET3Qj5IhKQoyjMwPb0vwGXOvwghgiifgAnhnJCKT8H38l-3g-59DDA6uGJzqMM4vS-MTsaH2GnYDckHC7sYomlj0O0eqGOzmUMfYD90MRW11SP1A8PQjKg39gqcO91me328M_D1svxcvBWrj9f3xfOqMBSRvuCMSUM4qSsqeOlYjZpKM9dQQawpOcOuqjkl0pVWY64ZQZw6KTkmjWNcaDoDd4fedYp_g8296nw2tm11sHHIiksshKDVCJYH0KSYc7JOrZPvdNoojNROo9r5UjtfSki116jKMXZ77B_qzjan0NEh3QJ-IW7r</recordid><startdate>19890701</startdate><enddate>19890701</enddate><creator>Lavie, E</creator><creator>Beaumier, P L</creator><creator>Brodzinsky, L</creator><creator>Hellström, K E</creator><creator>Hellström, I</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19890701</creationdate><title>Evaluation of L6, an anti-carcinoma murine monoclonal antibody, in tumor-bearing nude mice</title><author>Lavie, E ; Beaumier, P L ; Brodzinsky, L ; Hellström, K E ; Hellström, I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c302t-7669c272b53874f6b0d5a6fd382ec4761f5b7329f4ea17a62073f99712df678a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Animals</topic><topic>Antibodies, Monoclonal</topic><topic>Female</topic><topic>Gallium Radioisotopes</topic><topic>Immunoglobulin Fab Fragments</topic><topic>Iodine Radioisotopes</topic><topic>Metabolic Clearance Rate</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Nude</topic><topic>Neoplasm Transplantation</topic><topic>Neoplasms, Experimental - immunology</topic><topic>Neoplasms, Experimental - metabolism</topic><topic>Tissue Distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lavie, E</creatorcontrib><creatorcontrib>Beaumier, P L</creatorcontrib><creatorcontrib>Brodzinsky, L</creatorcontrib><creatorcontrib>Hellström, K E</creatorcontrib><creatorcontrib>Hellström, I</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Radiotherapy and oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lavie, E</au><au>Beaumier, P L</au><au>Brodzinsky, L</au><au>Hellström, K E</au><au>Hellström, I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of L6, an anti-carcinoma murine monoclonal antibody, in tumor-bearing nude mice</atitle><jtitle>Radiotherapy and oncology</jtitle><addtitle>Radiother Oncol</addtitle><date>1989-07-01</date><risdate>1989</risdate><volume>15</volume><issue>3</issue><spage>295</spage><epage>305</epage><pages>295-305</pages><issn>0167-8140</issn><abstract>L6 is a murine monoclonal antibody (MAb) binding to cells of most human carcinomas, mediating antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity, and inhibiting tumor growth in nude mice [10]. 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| ispartof | Radiotherapy and oncology, 1989-07, Vol.15 (3), p.295-305 |
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| language | eng |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Animals Antibodies, Monoclonal Female Gallium Radioisotopes Immunoglobulin Fab Fragments Iodine Radioisotopes Metabolic Clearance Rate Mice Mice, Inbred BALB C Mice, Nude Neoplasm Transplantation Neoplasms, Experimental - immunology Neoplasms, Experimental - metabolism Tissue Distribution |
| title | Evaluation of L6, an anti-carcinoma murine monoclonal antibody, in tumor-bearing nude mice |
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