Urinary Trypsinogen-2 Test Strip in Detecting ERCP-Induced Pancreatitis
Abstract BACKGROUND AND STUDY AIMS: We have evaluated a new urinary trypsinogen-2 test strip, based on the principle of immunochromatography, in the diagnosis of acute pancreatitis induced by endoscopic retrograde cholangiopancreatography (ERCP). PATIENTS AND METHODS: One hundred six consecutive pat...
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| Veröffentlicht in: | Endoscopy 1997-05, Vol.29 (4), p.247-251 |
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| container_title | Endoscopy |
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| creator | Kemppainen, E. Hedström, J. Puolakkainen, P. Halttunen, J. Sainio, V. Haapiainen, R. Stenman, U.-H. |
| description | Abstract
BACKGROUND AND STUDY AIMS: We have evaluated a new urinary trypsinogen-2 test strip, based on the principle of immunochromatography, in the diagnosis of acute pancreatitis induced by endoscopic retrograde cholangiopancreatography (ERCP).
PATIENTS AND METHODS: One hundred six consecutive patients undergoing ERCP (with opacification of the pancreatic duct) at the Helsinki University Central Hospital were included in the study. Patients were tested with a urinary trypsinogen-2 test strip six hours after ERCP. Quantitative trypsinogen-2 as well as serum and urine amylase values were measured before the procedure and six hours after it.
RESULTS: In patients developing pancreatitis after ERCP, the median urinary trypsinogen-2 concentration six hours after the endoscopic procedure was 1780 µg/l (range 29 - 10700 µg/l), and in patients without pancreatitis the median concentration was 3.6 µg/l (range 0.1 - 3390 µg/l; P |
| doi_str_mv | 10.1055/s-2007-1004184 |
| format | Article |
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BACKGROUND AND STUDY AIMS: We have evaluated a new urinary trypsinogen-2 test strip, based on the principle of immunochromatography, in the diagnosis of acute pancreatitis induced by endoscopic retrograde cholangiopancreatography (ERCP).
PATIENTS AND METHODS: One hundred six consecutive patients undergoing ERCP (with opacification of the pancreatic duct) at the Helsinki University Central Hospital were included in the study. Patients were tested with a urinary trypsinogen-2 test strip six hours after ERCP. Quantitative trypsinogen-2 as well as serum and urine amylase values were measured before the procedure and six hours after it.
RESULTS: In patients developing pancreatitis after ERCP, the median urinary trypsinogen-2 concentration six hours after the endoscopic procedure was 1780 µg/l (range 29 - 10700 µg/l), and in patients without pancreatitis the median concentration was 3.6 µg/l (range 0.1 - 3390 µg/l; P < 0.0001). The sensitivity and specificity figures for the urinary trypsinogen-2 test strip results in diagnosing post-ERCP pancreatitis were comparable (81 % and 97 %, respectively) to those for serum amylase (91 % and 96 %) and urine amylase measurements (81 % and 95 %). The test strip showed a good correlation (κ = 0.75) with the quantitative trypsinogen-2 assay.
CONCLUSIONS: The increase in urinary trypsinogen-2 concentration after ERCP reflects pancreatic injury, and can be detected by the test strip. Patients should be tested before the ERCP procedure as well, since elevated baseline values occur. The test is reliable and easy to perform even on an outpatient basis. However, its clinical usefulness requires evaluation in further trials.</description><identifier>ISSN: 0013-726X</identifier><identifier>EISSN: 1438-8812</identifier><identifier>DOI: 10.1055/s-2007-1004184</identifier><identifier>PMID: 9255526</identifier><identifier>CODEN: ENDCAM</identifier><language>eng</language><publisher>Stuttgart: Thieme</publisher><subject>Acute Disease ; Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Cholangiopancreatography, Endoscopic Retrograde - adverse effects ; Diagnosis, Differential ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Medical sciences ; Middle Aged ; Original Article ; Other diseases. Semiology ; Pancreatitis - diagnosis ; Pancreatitis - enzymology ; Pancreatitis - etiology ; Reagent Strips ; Sensitivity and Specificity ; Trypsinogen - metabolism ; Trypsinogen - urine ; Urinalysis</subject><ispartof>Endoscopy, 1997-05, Vol.29 (4), p.247-251</ispartof><rights>Georg Thieme Verlag KG Stuttgart · New York</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-5ec378dff01503deeb327caf759f2b417af5b1e39dbc2ac887be8a3f8cf995c53</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2007-1004184.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><link.rule.ids>314,780,784,3017,3018,27924,27925,54559</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2714575$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9255526$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kemppainen, E.</creatorcontrib><creatorcontrib>Hedström, J.</creatorcontrib><creatorcontrib>Puolakkainen, P.</creatorcontrib><creatorcontrib>Halttunen, J.</creatorcontrib><creatorcontrib>Sainio, V.</creatorcontrib><creatorcontrib>Haapiainen, R.</creatorcontrib><creatorcontrib>Stenman, U.-H.</creatorcontrib><title>Urinary Trypsinogen-2 Test Strip in Detecting ERCP-Induced Pancreatitis</title><title>Endoscopy</title><addtitle>Endoscopy</addtitle><description>Abstract
BACKGROUND AND STUDY AIMS: We have evaluated a new urinary trypsinogen-2 test strip, based on the principle of immunochromatography, in the diagnosis of acute pancreatitis induced by endoscopic retrograde cholangiopancreatography (ERCP).
PATIENTS AND METHODS: One hundred six consecutive patients undergoing ERCP (with opacification of the pancreatic duct) at the Helsinki University Central Hospital were included in the study. Patients were tested with a urinary trypsinogen-2 test strip six hours after ERCP. Quantitative trypsinogen-2 as well as serum and urine amylase values were measured before the procedure and six hours after it.
RESULTS: In patients developing pancreatitis after ERCP, the median urinary trypsinogen-2 concentration six hours after the endoscopic procedure was 1780 µg/l (range 29 - 10700 µg/l), and in patients without pancreatitis the median concentration was 3.6 µg/l (range 0.1 - 3390 µg/l; P < 0.0001). The sensitivity and specificity figures for the urinary trypsinogen-2 test strip results in diagnosing post-ERCP pancreatitis were comparable (81 % and 97 %, respectively) to those for serum amylase (91 % and 96 %) and urine amylase measurements (81 % and 95 %). The test strip showed a good correlation (κ = 0.75) with the quantitative trypsinogen-2 assay.
CONCLUSIONS: The increase in urinary trypsinogen-2 concentration after ERCP reflects pancreatic injury, and can be detected by the test strip. Patients should be tested before the ERCP procedure as well, since elevated baseline values occur. The test is reliable and easy to perform even on an outpatient basis. However, its clinical usefulness requires evaluation in further trials.</description><subject>Acute Disease</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Cholangiopancreatography, Endoscopic Retrograde - adverse effects</subject><subject>Diagnosis, Differential</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Original Article</subject><subject>Other diseases. Semiology</subject><subject>Pancreatitis - diagnosis</subject><subject>Pancreatitis - enzymology</subject><subject>Pancreatitis - etiology</subject><subject>Reagent Strips</subject><subject>Sensitivity and Specificity</subject><subject>Trypsinogen - metabolism</subject><subject>Trypsinogen - urine</subject><subject>Urinalysis</subject><issn>0013-726X</issn><issn>1438-8812</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kLtPwzAQhy0EKuWxsiFlQGwGP-LaGVEpD6kSCFqJzXKcMxglTrGTof89qRqxMZ2s-3x3vw-hC0puKBHiNmFGiMSUkJyq_ABNac4VVoqyQzQlhHIs2ezjGJ2k9L17EiImaFIwIQSbTdHjOvpg4jZbxe0m-dB-QsAsW0Hqsvcu-k3mQ3YPHdjOh89s8TZ_xc-h6i1U2asJNoLpfOfTGTpypk5wPtZTtH5YrOZPePny-Dy_W2LL1azDAiyXqnKOUEF4BVByJq1xUhSOlTmVxomSAi-q0jJjlZIlKMOdsq4ohBX8FF3v525i-9MPV-rGJwt1bQK0fdKyoEN2OhvAmz1oY5tSBKc30TdDUk2J3pnTSe_M6dHc8OFynNyXDVR_-Khq6F-NfZOsqV0c0vv0hzFJcyF3B-I91n15aEB_t30Mg5H_1v4CmW6Dog</recordid><startdate>19970501</startdate><enddate>19970501</enddate><creator>Kemppainen, E.</creator><creator>Hedström, J.</creator><creator>Puolakkainen, P.</creator><creator>Halttunen, J.</creator><creator>Sainio, V.</creator><creator>Haapiainen, R.</creator><creator>Stenman, U.-H.</creator><general>Thieme</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19970501</creationdate><title>Urinary Trypsinogen-2 Test Strip in Detecting ERCP-Induced Pancreatitis</title><author>Kemppainen, E. ; Hedström, J. ; Puolakkainen, P. ; Halttunen, J. ; Sainio, V. ; Haapiainen, R. ; Stenman, U.-H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-5ec378dff01503deeb327caf759f2b417af5b1e39dbc2ac887be8a3f8cf995c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Acute Disease</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Cholangiopancreatography, Endoscopic Retrograde - adverse effects</topic><topic>Diagnosis, Differential</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Original Article</topic><topic>Other diseases. Semiology</topic><topic>Pancreatitis - diagnosis</topic><topic>Pancreatitis - enzymology</topic><topic>Pancreatitis - etiology</topic><topic>Reagent Strips</topic><topic>Sensitivity and Specificity</topic><topic>Trypsinogen - metabolism</topic><topic>Trypsinogen - urine</topic><topic>Urinalysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kemppainen, E.</creatorcontrib><creatorcontrib>Hedström, J.</creatorcontrib><creatorcontrib>Puolakkainen, P.</creatorcontrib><creatorcontrib>Halttunen, J.</creatorcontrib><creatorcontrib>Sainio, V.</creatorcontrib><creatorcontrib>Haapiainen, R.</creatorcontrib><creatorcontrib>Stenman, U.-H.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Endoscopy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kemppainen, E.</au><au>Hedström, J.</au><au>Puolakkainen, P.</au><au>Halttunen, J.</au><au>Sainio, V.</au><au>Haapiainen, R.</au><au>Stenman, U.-H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Urinary Trypsinogen-2 Test Strip in Detecting ERCP-Induced Pancreatitis</atitle><jtitle>Endoscopy</jtitle><addtitle>Endoscopy</addtitle><date>1997-05-01</date><risdate>1997</risdate><volume>29</volume><issue>4</issue><spage>247</spage><epage>251</epage><pages>247-251</pages><issn>0013-726X</issn><eissn>1438-8812</eissn><coden>ENDCAM</coden><abstract>Abstract
BACKGROUND AND STUDY AIMS: We have evaluated a new urinary trypsinogen-2 test strip, based on the principle of immunochromatography, in the diagnosis of acute pancreatitis induced by endoscopic retrograde cholangiopancreatography (ERCP).
PATIENTS AND METHODS: One hundred six consecutive patients undergoing ERCP (with opacification of the pancreatic duct) at the Helsinki University Central Hospital were included in the study. Patients were tested with a urinary trypsinogen-2 test strip six hours after ERCP. Quantitative trypsinogen-2 as well as serum and urine amylase values were measured before the procedure and six hours after it.
RESULTS: In patients developing pancreatitis after ERCP, the median urinary trypsinogen-2 concentration six hours after the endoscopic procedure was 1780 µg/l (range 29 - 10700 µg/l), and in patients without pancreatitis the median concentration was 3.6 µg/l (range 0.1 - 3390 µg/l; P < 0.0001). The sensitivity and specificity figures for the urinary trypsinogen-2 test strip results in diagnosing post-ERCP pancreatitis were comparable (81 % and 97 %, respectively) to those for serum amylase (91 % and 96 %) and urine amylase measurements (81 % and 95 %). The test strip showed a good correlation (κ = 0.75) with the quantitative trypsinogen-2 assay.
CONCLUSIONS: The increase in urinary trypsinogen-2 concentration after ERCP reflects pancreatic injury, and can be detected by the test strip. Patients should be tested before the ERCP procedure as well, since elevated baseline values occur. The test is reliable and easy to perform even on an outpatient basis. However, its clinical usefulness requires evaluation in further trials.</abstract><cop>Stuttgart</cop><cop>New York, NY</cop><pub>Thieme</pub><pmid>9255526</pmid><doi>10.1055/s-2007-1004184</doi><tpages>5</tpages></addata></record> |
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| subjects | Acute Disease Adult Aged Aged, 80 and over Biological and medical sciences Cholangiopancreatography, Endoscopic Retrograde - adverse effects Diagnosis, Differential Female Gastroenterology. Liver. Pancreas. Abdomen Humans Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Middle Aged Original Article Other diseases. Semiology Pancreatitis - diagnosis Pancreatitis - enzymology Pancreatitis - etiology Reagent Strips Sensitivity and Specificity Trypsinogen - metabolism Trypsinogen - urine Urinalysis |
| title | Urinary Trypsinogen-2 Test Strip in Detecting ERCP-Induced Pancreatitis |
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