Uptake of 169Yb complexes in normal and tumour cells: Influence of ligand and metabolic cell activity and stability of cellular association
For better understanding of the accumulation of trivalent radiometal tracers in tumours, studies of uptake of different 169Yb complexes into cultured normal (V79/4) and tumour (KTCTL-2) cells were performed. Cellular uptake of 169Yb 3+ is dependent on both the metabolic activity of the cells and the...
Gespeichert in:
| Veröffentlicht in: | Nuclear medicine and biology 1997-05, Vol.24 (4), p.349-355 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 355 |
|---|---|
| container_issue | 4 |
| container_start_page | 349 |
| container_title | Nuclear medicine and biology |
| container_volume | 24 |
| creator | Kampf, G. Knop, G. Franke, W.-G. Bergmann, R. Johannsen, B. |
| description | For better understanding of the accumulation of trivalent radiometal tracers in tumours, studies of uptake of different
169Yb complexes into cultured normal (V79/4) and tumour (KTCTL-2) cells were performed. Cellular uptake of
169Yb
3+ is dependent on both the metabolic activity of the cells and the nature of the ligand used. Uptake of
169Yb
3+ from the citrate complex is an active cellular transport process but not tumour-specific. The
169Yb-aminopolycarboxylic acid complexes are taken up via a different, unknown mechanism, and in higher amounts by the tumour cells than by the V79/4 cell line, but the general features of uptake were principally the same with the normal and the tumour cells. Uptake of the complexes studied leads to a stable association of cellular components, which is a good premise for the therapeutic use of trivalent radiometals. |
| doi_str_mv | 10.1016/S0969-8051(97)00010-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_79187001</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0969805197000103</els_id><sourcerecordid>79187001</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2364-5bfc97241b37cda0a8ce8049be1d61b7b98a7c5ca7f317ef323cb38788c9abce3</originalsourceid><addsrcrecordid>eNqFkc1u1DAUhS0EKtOfR6jkBUJ0EbDjJI7ZIFT1T6rEgnbRlXV94yCDEw92UtFn4KVxMqPZsrAs63zH9-ocQs45-8gZbz59Z6pRRctq_kHJC8YYZ4V4RTa8lWWhGl69JpsD8pYcp_QzM03F2RE5UmUthag25O_jdoJfloae8kY9GYph2Hr7xybqRjqGOICnMHZ0mocwR4rW-_SZ3o29n-2Iq9G7HwuxnMFOYIJ3uIIUcHLPbnpZtZQl55dX9izy7CFSSCmgg8mF8ZS86cEne7a_T8jj9dXD5W1x_-3m7vLrfYGlaKqiNj0qWVbcCIkdMGjRtqxSxvKu4UYa1YLEGkH2gkvbi1KgEa1sW1Rg0IoT8n737zaG37NNkx5cWhaC0YY5aalyhjmrDNY7EGNIKdpeb6MbIL5ozvRSgl5L0EvCWkm9lqBF9p3vB8xmsN3BtU896-_2OiQE30cY0aUDVkrJFW8y9mWH2RzGs7NRJ3RL6J2LFifdBfefRf4BCeelkA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>79187001</pqid></control><display><type>article</type><title>Uptake of 169Yb complexes in normal and tumour cells: Influence of ligand and metabolic cell activity and stability of cellular association</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Kampf, G. ; Knop, G. ; Franke, W.-G. ; Bergmann, R. ; Johannsen, B.</creator><creatorcontrib>Kampf, G. ; Knop, G. ; Franke, W.-G. ; Bergmann, R. ; Johannsen, B.</creatorcontrib><description>For better understanding of the accumulation of trivalent radiometal tracers in tumours, studies of uptake of different
169Yb complexes into cultured normal (V79/4) and tumour (KTCTL-2) cells were performed. Cellular uptake of
169Yb
3+ is dependent on both the metabolic activity of the cells and the nature of the ligand used. Uptake of
169Yb
3+ from the citrate complex is an active cellular transport process but not tumour-specific. The
169Yb-aminopolycarboxylic acid complexes are taken up via a different, unknown mechanism, and in higher amounts by the tumour cells than by the V79/4 cell line, but the general features of uptake were principally the same with the normal and the tumour cells. Uptake of the complexes studied leads to a stable association of cellular components, which is a good premise for the therapeutic use of trivalent radiometals.</description><identifier>ISSN: 0969-8051</identifier><identifier>EISSN: 1872-9614</identifier><identifier>DOI: 10.1016/S0969-8051(97)00010-3</identifier><identifier>PMID: 9257334</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Biological transport ; Cell Line ; Contrast media. Radiopharmaceuticals ; Cricetinae ; Humans ; Label ; Ligands ; Medical sciences ; Neoplasms - metabolism ; Organometallic compounds ; Pharmacology. Drug treatments ; Radioisotopes - pharmacokinetics ; Temperature ; Tumour cells ; Ytterbium - pharmacokinetics</subject><ispartof>Nuclear medicine and biology, 1997-05, Vol.24 (4), p.349-355</ispartof><rights>1997</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2364-5bfc97241b37cda0a8ce8049be1d61b7b98a7c5ca7f317ef323cb38788c9abce3</citedby><cites>FETCH-LOGICAL-c2364-5bfc97241b37cda0a8ce8049be1d61b7b98a7c5ca7f317ef323cb38788c9abce3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0969-8051(97)00010-3$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2771916$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9257334$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kampf, G.</creatorcontrib><creatorcontrib>Knop, G.</creatorcontrib><creatorcontrib>Franke, W.-G.</creatorcontrib><creatorcontrib>Bergmann, R.</creatorcontrib><creatorcontrib>Johannsen, B.</creatorcontrib><title>Uptake of 169Yb complexes in normal and tumour cells: Influence of ligand and metabolic cell activity and stability of cellular association</title><title>Nuclear medicine and biology</title><addtitle>Nucl Med Biol</addtitle><description>For better understanding of the accumulation of trivalent radiometal tracers in tumours, studies of uptake of different
169Yb complexes into cultured normal (V79/4) and tumour (KTCTL-2) cells were performed. Cellular uptake of
169Yb
3+ is dependent on both the metabolic activity of the cells and the nature of the ligand used. Uptake of
169Yb
3+ from the citrate complex is an active cellular transport process but not tumour-specific. The
169Yb-aminopolycarboxylic acid complexes are taken up via a different, unknown mechanism, and in higher amounts by the tumour cells than by the V79/4 cell line, but the general features of uptake were principally the same with the normal and the tumour cells. Uptake of the complexes studied leads to a stable association of cellular components, which is a good premise for the therapeutic use of trivalent radiometals.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biological transport</subject><subject>Cell Line</subject><subject>Contrast media. Radiopharmaceuticals</subject><subject>Cricetinae</subject><subject>Humans</subject><subject>Label</subject><subject>Ligands</subject><subject>Medical sciences</subject><subject>Neoplasms - metabolism</subject><subject>Organometallic compounds</subject><subject>Pharmacology. Drug treatments</subject><subject>Radioisotopes - pharmacokinetics</subject><subject>Temperature</subject><subject>Tumour cells</subject><subject>Ytterbium - pharmacokinetics</subject><issn>0969-8051</issn><issn>1872-9614</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1DAUhS0EKtOfR6jkBUJ0EbDjJI7ZIFT1T6rEgnbRlXV94yCDEw92UtFn4KVxMqPZsrAs63zH9-ocQs45-8gZbz59Z6pRRctq_kHJC8YYZ4V4RTa8lWWhGl69JpsD8pYcp_QzM03F2RE5UmUthag25O_jdoJfloae8kY9GYph2Hr7xybqRjqGOICnMHZ0mocwR4rW-_SZ3o29n-2Iq9G7HwuxnMFOYIJ3uIIUcHLPbnpZtZQl55dX9izy7CFSSCmgg8mF8ZS86cEne7a_T8jj9dXD5W1x_-3m7vLrfYGlaKqiNj0qWVbcCIkdMGjRtqxSxvKu4UYa1YLEGkH2gkvbi1KgEa1sW1Rg0IoT8n737zaG37NNkx5cWhaC0YY5aalyhjmrDNY7EGNIKdpeb6MbIL5ozvRSgl5L0EvCWkm9lqBF9p3vB8xmsN3BtU896-_2OiQE30cY0aUDVkrJFW8y9mWH2RzGs7NRJ3RL6J2LFifdBfefRf4BCeelkA</recordid><startdate>199705</startdate><enddate>199705</enddate><creator>Kampf, G.</creator><creator>Knop, G.</creator><creator>Franke, W.-G.</creator><creator>Bergmann, R.</creator><creator>Johannsen, B.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199705</creationdate><title>Uptake of 169Yb complexes in normal and tumour cells: Influence of ligand and metabolic cell activity and stability of cellular association</title><author>Kampf, G. ; Knop, G. ; Franke, W.-G. ; Bergmann, R. ; Johannsen, B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2364-5bfc97241b37cda0a8ce8049be1d61b7b98a7c5ca7f317ef323cb38788c9abce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Biological transport</topic><topic>Cell Line</topic><topic>Contrast media. Radiopharmaceuticals</topic><topic>Cricetinae</topic><topic>Humans</topic><topic>Label</topic><topic>Ligands</topic><topic>Medical sciences</topic><topic>Neoplasms - metabolism</topic><topic>Organometallic compounds</topic><topic>Pharmacology. Drug treatments</topic><topic>Radioisotopes - pharmacokinetics</topic><topic>Temperature</topic><topic>Tumour cells</topic><topic>Ytterbium - pharmacokinetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kampf, G.</creatorcontrib><creatorcontrib>Knop, G.</creatorcontrib><creatorcontrib>Franke, W.-G.</creatorcontrib><creatorcontrib>Bergmann, R.</creatorcontrib><creatorcontrib>Johannsen, B.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nuclear medicine and biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kampf, G.</au><au>Knop, G.</au><au>Franke, W.-G.</au><au>Bergmann, R.</au><au>Johannsen, B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Uptake of 169Yb complexes in normal and tumour cells: Influence of ligand and metabolic cell activity and stability of cellular association</atitle><jtitle>Nuclear medicine and biology</jtitle><addtitle>Nucl Med Biol</addtitle><date>1997-05</date><risdate>1997</risdate><volume>24</volume><issue>4</issue><spage>349</spage><epage>355</epage><pages>349-355</pages><issn>0969-8051</issn><eissn>1872-9614</eissn><abstract>For better understanding of the accumulation of trivalent radiometal tracers in tumours, studies of uptake of different
169Yb complexes into cultured normal (V79/4) and tumour (KTCTL-2) cells were performed. Cellular uptake of
169Yb
3+ is dependent on both the metabolic activity of the cells and the nature of the ligand used. Uptake of
169Yb
3+ from the citrate complex is an active cellular transport process but not tumour-specific. The
169Yb-aminopolycarboxylic acid complexes are taken up via a different, unknown mechanism, and in higher amounts by the tumour cells than by the V79/4 cell line, but the general features of uptake were principally the same with the normal and the tumour cells. Uptake of the complexes studied leads to a stable association of cellular components, which is a good premise for the therapeutic use of trivalent radiometals.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>9257334</pmid><doi>10.1016/S0969-8051(97)00010-3</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0969-8051 |
| ispartof | Nuclear medicine and biology, 1997-05, Vol.24 (4), p.349-355 |
| issn | 0969-8051 1872-9614 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79187001 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Biological and medical sciences Biological transport Cell Line Contrast media. Radiopharmaceuticals Cricetinae Humans Label Ligands Medical sciences Neoplasms - metabolism Organometallic compounds Pharmacology. Drug treatments Radioisotopes - pharmacokinetics Temperature Tumour cells Ytterbium - pharmacokinetics |
| title | Uptake of 169Yb complexes in normal and tumour cells: Influence of ligand and metabolic cell activity and stability of cellular association |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T22%3A30%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Uptake%20of%20169Yb%20complexes%20in%20normal%20and%20tumour%20cells:%20Influence%20of%20ligand%20and%20metabolic%20cell%20activity%20and%20stability%20of%20cellular%20association&rft.jtitle=Nuclear%20medicine%20and%20biology&rft.au=Kampf,%20G.&rft.date=1997-05&rft.volume=24&rft.issue=4&rft.spage=349&rft.epage=355&rft.pages=349-355&rft.issn=0969-8051&rft.eissn=1872-9614&rft_id=info:doi/10.1016/S0969-8051(97)00010-3&rft_dat=%3Cproquest_cross%3E79187001%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=79187001&rft_id=info:pmid/9257334&rft_els_id=S0969805197000103&rfr_iscdi=true |