Improvement of Nerve Conduction Velocity in Mutant Diabetic Mice by Aldose Reductase Inhibitor without Affecting Nerve myo-Inositol Content

The sciatic motor nerve conduction velocity of mutant diabetic C57BL/Ks mice was significantly improved from 30.0±1.4 to 38.0±4.6m/s by treatment with the aldose reductase inhibitor 1-[(β-naphthyl)sulfonyl]hydantoin (30 mg/kg/d) for 2 weeks. The treatment, however, did not cause any significant chan...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1989/06/25, Vol.37(6), pp.1581-1582
Hauptverfasser:	MIWA, Ichitomo, KANBARA, Motoya, OKUDA, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehyde Reductase - antagonists & inhibitors aldose reductase aldose reductase inhibitor Animals Biological and medical sciences Diabetes Mellitus, Experimental - physiopathology Female General and cellular metabolism. Vitamins Inositol - metabolism Male Medical sciences Mice Mice, Inbred C57BL mutant diabetic mice myo-inositol nerve conduction velocity Neural Conduction - drug effects Neurons - metabolism Neurons - physiology Pharmacology. Drug treatments sorbitol Sugar Alcohol Dehydrogenases - antagonists & inhibitors
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