Antiarrhythmic and electrophysiological effects of the novel KATP channel opener, rilmakalim, in rabbit cardiac cells

1. The effects of rilmakalim, a potassium channel opener, were studied on rabbit cardiac Purkinje, ventricular muscle and atrial fibers, with the use of conventional microelectrode techniques. 2. Rilmakalim (0.24-7.2 microM) shortened, in a concentration-dependent manner, the action potential durati...

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Veröffentlicht in:	General pharmacology 1997-08, Vol.29 (2), p.201-205
Hauptverfasser:	RICCIOPPO, F. NETO, MESQUITA, O. JR, BELLEJO OLIVERA, G
Format:	Artikel
Sprache:	eng
Schlagworte:	2,4-Dinitrophenol - pharmacology Action Potentials - drug effects Animals Anti-Arrhythmia Agents - pharmacology Antiarythmic agents Biological and medical sciences Cardiovascular system Chromans - pharmacology Glyburide - pharmacology In Vitro Techniques Medical sciences Pharmacology. Drug treatments Potassium Channels - drug effects Purkinje Fibers - drug effects Purkinje Fibers - physiology Pyrrolidines - pharmacology Rabbits Sinoatrial Node - drug effects Sinoatrial Node - physiology Sodium Salicylate - pharmacology Tetraethylammonium Tetraethylammonium Compounds - pharmacology
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