Troglitazone ameliorates insulin resistance in patients with Werner's syndrome

Insulin resistance in Werner's syndrome (WS) is probably due to defective signaling distal to the insulin receptor. To analyze the metabolic effects of troglitazone (TRO) in these patients, we performed frequently sampled iv glucose tolerance tests. Glucose kinetics were analyzed by the minimal...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 1997-08, Vol.82 (8), p.2391-2395
Hauptverfasser:	IZUMINO, K, SAKAMAKI, H, NAGATAKI, S, ISHIBASHI, M, TAKINO, H, YAMASAKI, H, YAMAGUCHI, Y, CHIKUBA, N, MATSUMOTO, K, AKAZAWA, S, TOKUYAMA, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Blood Glucose - metabolism Chromans - therapeutic use Female General and cellular metabolism. Vitamins Glucose Tolerance Test Humans Hypoglycemic Agents - therapeutic use Insulin - blood Insulin - metabolism Insulin Resistance Insulin Secretion Kinetics Male Medical sciences Middle Aged Pharmacology. Drug treatments Thiazoles - therapeutic use Thiazolidinediones Troglitazone Werner Syndrome - drug therapy Werner Syndrome - physiopathology
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