Carbohydrate biguanides as potential hypoglycemic agents

A series of monosaccharides containing a biguanide functionality was prepared and evaluated for hypoglycemic activity. Among the analogues prepared were those involving D-glucose substituted on the 6- or 1-position (19 and 24), D-galactose substituted on the 6-position (7), and D-arabinose (31). The...

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Veröffentlicht in:	Journal of medicinal chemistry 1989-09, Vol.32 (9), p.2110-2116
Hauptverfasser:	Reitz, Allen B, Tuman, Robert W, Marchione, Carol S, Jordan, Alfonzo D, Bowden, Charles R, Maryanoff, Bruce E
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Biguanides - administration & dosage Biguanides - chemical synthesis Carbohydrates with 4, 5, 6, ... C atoms, dissacharides and oligosaccharides Carbohydrates. Nucleosides and nucleotides Chemistry Exact sciences and technology Glucose Tolerance Test Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - chemical synthesis Male Mass Spectrometry Metformin - administration & dosage Monosaccharides - administration & dosage Monosaccharides - chemical synthesis Organic chemistry Phenformin - administration & dosage Preparations and properties Rats Rats, Inbred Strains Structure-Activity Relationship
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