Decreased levels of circulating CD4 + T lymphocytes during normal human pregnancy
Peripheral blood mononuclear cell (PBMC) populations during human pregnancy have been investigated by many authors, although the different results obtained, principally in relation to T cells, are very discrepant. In this study we aimed to exclude all the possible causes of these discrepancies: smal...
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| Veröffentlicht in: | Journal of reproductive immunology 1989-05, Vol.15 (2), p.103-111 |
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| container_title | Journal of reproductive immunology |
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| creator | Castilla, JoséA. Rueda, Ricardo Luisa Vargas, M. González-Gómez, Francisco García-Olivares, Enrique |
| description | Peripheral blood mononuclear cell (PBMC) populations during human pregnancy have been investigated by many authors, although the different results obtained, principally in relation to T cells, are very discrepant. In this study we aimed to exclude all the possible causes of these discrepancies: small sample size; diurnal rhythm of CD4
+ T cells; smoking habits; haemodilution which occurs during pregnancy and inappropriate statistical analysis; in order to determine whether gestation has a definite effect on PBMC populations. We found that the percentage of CD4
+ T lymphocytes decreases in the first and second trimesters, returns to the non-pregnant level in the third trimester and remains there in the post-partum period. The percentages of CD3
+ T lymphocytes run parallel to those of CD4
+ while CD8
+ T lymphocytes do not vary. The proportion of CD16
+ cells, which include mature NK cells, diminishes in the second trimester and this reduction is maintained in the third trimester and the puerperium. No variation was found in the other PBMC studied (CD20
+ lymphocytes, CD14
+ monocytes and D/DR
+ cells). When parity was considered no difference was seen between primiparous and multiparous women in any of the cell populations tested. |
| doi_str_mv | 10.1016/0165-0378(89)90030-2 |
| format | Article |
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+ T cells; smoking habits; haemodilution which occurs during pregnancy and inappropriate statistical analysis; in order to determine whether gestation has a definite effect on PBMC populations. We found that the percentage of CD4
+ T lymphocytes decreases in the first and second trimesters, returns to the non-pregnant level in the third trimester and remains there in the post-partum period. The percentages of CD3
+ T lymphocytes run parallel to those of CD4
+ while CD8
+ T lymphocytes do not vary. The proportion of CD16
+ cells, which include mature NK cells, diminishes in the second trimester and this reduction is maintained in the third trimester and the puerperium. No variation was found in the other PBMC studied (CD20
+ lymphocytes, CD14
+ monocytes and D/DR
+ cells). When parity was considered no difference was seen between primiparous and multiparous women in any of the cell populations tested.</description><identifier>ISSN: 0165-0378</identifier><identifier>EISSN: 1872-7603</identifier><identifier>DOI: 10.1016/0165-0378(89)90030-2</identifier><identifier>PMID: 2570147</identifier><identifier>CODEN: JRIMDR</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Adult ; Biological and medical sciences ; Blood Volume ; CD4-Positive T-Lymphocytes ; Circadian Rhythm ; Female ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Humans ; Immune Tolerance ; Immunity, Cellular ; Immunobiology ; Leukocyte Count ; Leukocytes, Mononuclear - classification ; Modulation of the immune response (stimulation, suppression) ; Parity ; Postpartum Period - immunology ; Pregnancy - immunology ; Smoking</subject><ispartof>Journal of reproductive immunology, 1989-05, Vol.15 (2), p.103-111</ispartof><rights>1989</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c302t-8d41ebf664981d98189ae332783c1216a5861bd234a976a89325358a8dcaa7be3</citedby><cites>FETCH-LOGICAL-c302t-8d41ebf664981d98189ae332783c1216a5861bd234a976a89325358a8dcaa7be3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0165-0378(89)90030-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19298878$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2570147$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Castilla, JoséA.</creatorcontrib><creatorcontrib>Rueda, Ricardo</creatorcontrib><creatorcontrib>Luisa Vargas, M.</creatorcontrib><creatorcontrib>González-Gómez, Francisco</creatorcontrib><creatorcontrib>García-Olivares, Enrique</creatorcontrib><title>Decreased levels of circulating CD4 + T lymphocytes during normal human pregnancy</title><title>Journal of reproductive immunology</title><addtitle>J Reprod Immunol</addtitle><description>Peripheral blood mononuclear cell (PBMC) populations during human pregnancy have been investigated by many authors, although the different results obtained, principally in relation to T cells, are very discrepant. In this study we aimed to exclude all the possible causes of these discrepancies: small sample size; diurnal rhythm of CD4
+ T cells; smoking habits; haemodilution which occurs during pregnancy and inappropriate statistical analysis; in order to determine whether gestation has a definite effect on PBMC populations. We found that the percentage of CD4
+ T lymphocytes decreases in the first and second trimesters, returns to the non-pregnant level in the third trimester and remains there in the post-partum period. The percentages of CD3
+ T lymphocytes run parallel to those of CD4
+ while CD8
+ T lymphocytes do not vary. The proportion of CD16
+ cells, which include mature NK cells, diminishes in the second trimester and this reduction is maintained in the third trimester and the puerperium. No variation was found in the other PBMC studied (CD20
+ lymphocytes, CD14
+ monocytes and D/DR
+ cells). When parity was considered no difference was seen between primiparous and multiparous women in any of the cell populations tested.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Blood Volume</subject><subject>CD4-Positive T-Lymphocytes</subject><subject>Circadian Rhythm</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Humans</subject><subject>Immune Tolerance</subject><subject>Immunity, Cellular</subject><subject>Immunobiology</subject><subject>Leukocyte Count</subject><subject>Leukocytes, Mononuclear - classification</subject><subject>Modulation of the immune response (stimulation, suppression)</subject><subject>Parity</subject><subject>Postpartum Period - immunology</subject><subject>Pregnancy - immunology</subject><subject>Smoking</subject><issn>0165-0378</issn><issn>1872-7603</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9r3DAQxUVoSLfbfIMWdGlpCU71z5Z0KZRNmgQCoZCexaw0TlRkeyvZgf329WaX9JbDMIf35jHvR8gHzs454823eeqKSW2-GPvVMiZZJY7IghstKt0w-YYsXixvybtS_jDGNbP8hJyIWjOu9IL8ukCfEQoGmvAJU6FDS33Mfkowxv6Bri4UPaP3NG27zePgtyMWGqa8k_ohd5Do49RBTzcZH3ro_fY9OW4hFTw97CX5_fPyfnVd3d5d3ax-3FZeMjFWJiiO67ZplDU8zGMsoJRCG-m54A3UpuHrIKQCqxswVopa1gZM8AB6jXJJPu9zN3n4O2EZXReLx5Sgx2EqTltulBJqNqq90eehlIyt2-TYQd46ztyOpNthcjtMzlj3TNKJ-ezjIX9adxhejg7oZv3TQYfiIbV5Lh_L_2wrrDFzmyX5vvfNcPEpYnbFR-w9hpjRjy4M8fVH_gGKY43i</recordid><startdate>198905</startdate><enddate>198905</enddate><creator>Castilla, JoséA.</creator><creator>Rueda, Ricardo</creator><creator>Luisa Vargas, M.</creator><creator>González-Gómez, Francisco</creator><creator>García-Olivares, Enrique</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198905</creationdate><title>Decreased levels of circulating CD4 + T lymphocytes during normal human pregnancy</title><author>Castilla, JoséA. ; Rueda, Ricardo ; Luisa Vargas, M. ; González-Gómez, Francisco ; García-Olivares, Enrique</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c302t-8d41ebf664981d98189ae332783c1216a5861bd234a976a89325358a8dcaa7be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Blood Volume</topic><topic>CD4-Positive T-Lymphocytes</topic><topic>Circadian Rhythm</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Humans</topic><topic>Immune Tolerance</topic><topic>Immunity, Cellular</topic><topic>Immunobiology</topic><topic>Leukocyte Count</topic><topic>Leukocytes, Mononuclear - classification</topic><topic>Modulation of the immune response (stimulation, suppression)</topic><topic>Parity</topic><topic>Postpartum Period - immunology</topic><topic>Pregnancy - immunology</topic><topic>Smoking</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Castilla, JoséA.</creatorcontrib><creatorcontrib>Rueda, Ricardo</creatorcontrib><creatorcontrib>Luisa Vargas, M.</creatorcontrib><creatorcontrib>González-Gómez, Francisco</creatorcontrib><creatorcontrib>García-Olivares, Enrique</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of reproductive immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Castilla, JoséA.</au><au>Rueda, Ricardo</au><au>Luisa Vargas, M.</au><au>González-Gómez, Francisco</au><au>García-Olivares, Enrique</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Decreased levels of circulating CD4 + T lymphocytes during normal human pregnancy</atitle><jtitle>Journal of reproductive immunology</jtitle><addtitle>J Reprod Immunol</addtitle><date>1989-05</date><risdate>1989</risdate><volume>15</volume><issue>2</issue><spage>103</spage><epage>111</epage><pages>103-111</pages><issn>0165-0378</issn><eissn>1872-7603</eissn><coden>JRIMDR</coden><abstract>Peripheral blood mononuclear cell (PBMC) populations during human pregnancy have been investigated by many authors, although the different results obtained, principally in relation to T cells, are very discrepant. In this study we aimed to exclude all the possible causes of these discrepancies: small sample size; diurnal rhythm of CD4
+ T cells; smoking habits; haemodilution which occurs during pregnancy and inappropriate statistical analysis; in order to determine whether gestation has a definite effect on PBMC populations. We found that the percentage of CD4
+ T lymphocytes decreases in the first and second trimesters, returns to the non-pregnant level in the third trimester and remains there in the post-partum period. The percentages of CD3
+ T lymphocytes run parallel to those of CD4
+ while CD8
+ T lymphocytes do not vary. The proportion of CD16
+ cells, which include mature NK cells, diminishes in the second trimester and this reduction is maintained in the third trimester and the puerperium. No variation was found in the other PBMC studied (CD20
+ lymphocytes, CD14
+ monocytes and D/DR
+ cells). When parity was considered no difference was seen between primiparous and multiparous women in any of the cell populations tested.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>2570147</pmid><doi>10.1016/0165-0378(89)90030-2</doi><tpages>9</tpages></addata></record> |
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| ispartof | Journal of reproductive immunology, 1989-05, Vol.15 (2), p.103-111 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adult Biological and medical sciences Blood Volume CD4-Positive T-Lymphocytes Circadian Rhythm Female Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immune Tolerance Immunity, Cellular Immunobiology Leukocyte Count Leukocytes, Mononuclear - classification Modulation of the immune response (stimulation, suppression) Parity Postpartum Period - immunology Pregnancy - immunology Smoking |
| title | Decreased levels of circulating CD4 + T lymphocytes during normal human pregnancy |
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