Alpha 2-adrenergic, kappa-opiate, and P1-purinergic autoreceptors have mutually antagonistic effects: a new regulatory mechanism?

Rat cortical synaptosomes prepared on four-step discontinuous Percoll density gradients were loaded with the fluorescent Ca2+-indicator fura-2 to allow measurement of the intrasynaptosomal free calcium concentration ([Ca2+]i). When P1-purinergic, alpha 2-adrenergic, or kappa-opiate agonists were inc...

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Veröffentlicht in:	Journal of neurochemistry 1989-10, Vol.53 (4), p.1077-1082
Hauptverfasser:	Adamson, P, Mantzouridis, T, Xiang, J Z, Hajimohammadreza, I, Brammer, M J, Campbell, I C
Format:	Artikel
Sprache:	eng
Schlagworte:	3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer Adenosine - analogs & derivatives Adrenergic alpha-Antagonists - pharmacology Analgesics - pharmacology Animals Benzofurans Caffeine - pharmacology Calcium - metabolism Cerebral Cortex - metabolism Clonidine - pharmacology Dioxanes - pharmacology Fluorescent Dyes Fura-2 Homeostasis Idazoxan Male Naloxone - pharmacology Phenylisopropyladenosine - pharmacology Pyrrolidines - pharmacology Rats Rats, Inbred Strains Receptors, Adrenergic, alpha - physiology Receptors, Opioid - physiology Receptors, Opioid, kappa Receptors, Purinergic - physiology Synaptosomes - drug effects Synaptosomes - metabolism
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