Histamine H3 receptor activation selectively inhibits dopamine D1 receptor-dependent [3H]GABA release from depolarization-stimulated slices of rat substantia nigra pars reticulata

The release of [3H]GABA from slices of rat substantia nigra pars reticulata induced by increasing extracellular K+ from 6 to 15 mM in the presence of 10 microM sulpiride was inhibited by 73 +/- 3% by 1 microM SCH 23390, consistent with a large component of release dependent upon D1 receptor activati...

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Veröffentlicht in:	Neuroscience 1997-09, Vol.80 (1), p.241-249
Hauptverfasser:	GARCIA, M, FLORAN, B, ARIAS-MONTANO, J. A, YOUNG, J. M, ACEVES, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Fundamental and applied biological sciences. Psychology gamma-Aminobutyric Acid - metabolism Histamine - pharmacology Male Neurotransmitter Agents - metabolism Potassium - pharmacology Radioligand Assay Rats Rats, Wistar Receptors, Dopamine D1 - drug effects Receptors, Histamine H3 - drug effects Receptors, Histamine H3 - physiology Substantia Nigra - drug effects Substantia Nigra - metabolism Vertebrates: nervous system and sense organs
Online-Zugang:	Volltext
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