Natural behavior polymorphism due to a cGMP-dependent protein kinase of Drosophila
Naturally occuring polymorphisms in behavior are dlfficult to map genetically and thus are refractory to molecular characterization. An exception is the foraging gene (for), a gene that has two naturally occurring variants in Drosophila melanogaster food-search behavior: rover and sitter. Molecular...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1997-08, Vol.277 (5327), p.834-836 |
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| creator | Osborne, K.A. (New York University, New York, NY.) Robichon, A Burgess, E Butland, S Shaw, R.A Coulthard, A Pereira, H.S Greenspan, R.J Sokolowski, M.B |
| description | Naturally occuring polymorphisms in behavior are dlfficult to map genetically and thus are refractory to molecular characterization. An exception is the foraging gene (for), a gene that has two naturally occurring variants in Drosophila melanogaster food-search behavior: rover and sitter. Molecular mapping placed for mutations in the dg2 gene, which encodes a cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG). Rovers had higher PKG activity than sitters, and transgenic sitters expressing a dg2 comlementary DNA from rover showed transformation of behavior to rover. Thus, PKG levels affected food-search behavior, and natural variation in PKG activity accounted for a behavioral polymorphism |
| doi_str_mv | 10.1126/science.277.5327.834 |
| format | Article |
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(New York University, New York, NY.) ; Robichon, A ; Burgess, E ; Butland, S ; Shaw, R.A ; Coulthard, A ; Pereira, H.S ; Greenspan, R.J ; Sokolowski, M.B</creator><creatorcontrib>Osborne, K.A. (New York University, New York, NY.) ; Robichon, A ; Burgess, E ; Butland, S ; Shaw, R.A ; Coulthard, A ; Pereira, H.S ; Greenspan, R.J ; Sokolowski, M.B</creatorcontrib><description>Naturally occuring polymorphisms in behavior are dlfficult to map genetically and thus are refractory to molecular characterization. An exception is the foraging gene (for), a gene that has two naturally occurring variants in Drosophila melanogaster food-search behavior: rover and sitter. Molecular mapping placed for mutations in the dg2 gene, which encodes a cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG). Rovers had higher PKG activity than sitters, and transgenic sitters expressing a dg2 comlementary DNA from rover showed transformation of behavior to rover. Thus, PKG levels affected food-search behavior, and natural variation in PKG activity accounted for a behavioral polymorphism</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.277.5327.834</identifier><identifier>PMID: 9242616</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Society for the Advancement of Science</publisher><subject>Alleles ; Anatomy ; Animal behavior ; Animals ; Animals, Genetically Modified ; Associative Learning ; Behavior ; BEHAVIOR PATTERNS ; BEHAVIOUR ; Biological and medical sciences ; Classical genetics, quantitative genetics, hybrids ; COMPORTAMIENTO ; COMPORTEMENT ; Cyclic GMP - metabolism ; Cyclic GMP-Dependent Protein Kinases - genetics ; Cyclic GMP-Dependent Protein Kinases - metabolism ; Drosophila ; DROSOPHILA MELANOGASTER ; Drosophila melanogaster - genetics ; Drosophila melanogaster - physiology ; Feeding Behavior ; Foraging ; Fruit-flies ; Fundamental and applied biological sciences. Psychology ; Genes ; Genes, Insect ; Genetic aspects ; Genetic mutation ; GENETIC POLYMORPHISM ; Genetics ; Genetics of eukaryotes. Biological and molecular evolution ; Insect larvae ; Insects ; Invertebrata ; Larva - genetics ; Larva - physiology ; Larvae ; Mutation ; Neurons ; Phenotype ; POLIMORFISMO GENETICO ; Polymorphism, Genetic ; POLYMORPHISME GENETIQUE ; PROTEIN KINASE ; PROTEINA QUINASA ; PROTEINE KINASE ; Proteins ; RNA ; SEARCHING BEHAVIOR ; Shock heating ; Signal Transduction ; Transgenic animals</subject><ispartof>Science (American Association for the Advancement of Science), 1997-08, Vol.277 (5327), p.834-836</ispartof><rights>Copyright 1997 American Association for the Advancement of Science</rights><rights>1997 INIST-CNRS</rights><rights>COPYRIGHT 1997 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1997 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Aug 8, 1997</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c738t-67cddf1dfa4246bf8d79c9dd681494d1c7cf70f6e7da2f0f8cc355deca1c1abe3</citedby><cites>FETCH-LOGICAL-c738t-67cddf1dfa4246bf8d79c9dd681494d1c7cf70f6e7da2f0f8cc355deca1c1abe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2893134$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2893134$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,2871,2872,27903,27904,57995,58228</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2776751$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9242616$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Osborne, K.A. (New York University, New York, NY.)</creatorcontrib><creatorcontrib>Robichon, A</creatorcontrib><creatorcontrib>Burgess, E</creatorcontrib><creatorcontrib>Butland, S</creatorcontrib><creatorcontrib>Shaw, R.A</creatorcontrib><creatorcontrib>Coulthard, A</creatorcontrib><creatorcontrib>Pereira, H.S</creatorcontrib><creatorcontrib>Greenspan, R.J</creatorcontrib><creatorcontrib>Sokolowski, M.B</creatorcontrib><title>Natural behavior polymorphism due to a cGMP-dependent protein kinase of Drosophila</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Naturally occuring polymorphisms in behavior are dlfficult to map genetically and thus are refractory to molecular characterization. An exception is the foraging gene (for), a gene that has two naturally occurring variants in Drosophila melanogaster food-search behavior: rover and sitter. Molecular mapping placed for mutations in the dg2 gene, which encodes a cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG). Rovers had higher PKG activity than sitters, and transgenic sitters expressing a dg2 comlementary DNA from rover showed transformation of behavior to rover. Thus, PKG levels affected food-search behavior, and natural variation in PKG activity accounted for a behavioral polymorphism</description><subject>Alleles</subject><subject>Anatomy</subject><subject>Animal behavior</subject><subject>Animals</subject><subject>Animals, Genetically Modified</subject><subject>Associative Learning</subject><subject>Behavior</subject><subject>BEHAVIOR PATTERNS</subject><subject>BEHAVIOUR</subject><subject>Biological and medical sciences</subject><subject>Classical genetics, quantitative genetics, hybrids</subject><subject>COMPORTAMIENTO</subject><subject>COMPORTEMENT</subject><subject>Cyclic GMP - metabolism</subject><subject>Cyclic GMP-Dependent Protein Kinases - genetics</subject><subject>Cyclic GMP-Dependent Protein Kinases - metabolism</subject><subject>Drosophila</subject><subject>DROSOPHILA MELANOGASTER</subject><subject>Drosophila melanogaster - genetics</subject><subject>Drosophila melanogaster - physiology</subject><subject>Feeding Behavior</subject><subject>Foraging</subject><subject>Fruit-flies</subject><subject>Fundamental and applied biological sciences. 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Psychology</topic><topic>Genes</topic><topic>Genes, Insect</topic><topic>Genetic aspects</topic><topic>Genetic mutation</topic><topic>GENETIC POLYMORPHISM</topic><topic>Genetics</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>Insect larvae</topic><topic>Insects</topic><topic>Invertebrata</topic><topic>Larva - genetics</topic><topic>Larva - physiology</topic><topic>Larvae</topic><topic>Mutation</topic><topic>Neurons</topic><topic>Phenotype</topic><topic>POLIMORFISMO GENETICO</topic><topic>Polymorphism, Genetic</topic><topic>POLYMORPHISME GENETIQUE</topic><topic>PROTEIN KINASE</topic><topic>PROTEINA QUINASA</topic><topic>PROTEINE KINASE</topic><topic>Proteins</topic><topic>RNA</topic><topic>SEARCHING BEHAVIOR</topic><topic>Shock heating</topic><topic>Signal Transduction</topic><topic>Transgenic animals</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Osborne, K.A. 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(New York University, New York, NY.)</au><au>Robichon, A</au><au>Burgess, E</au><au>Butland, S</au><au>Shaw, R.A</au><au>Coulthard, A</au><au>Pereira, H.S</au><au>Greenspan, R.J</au><au>Sokolowski, M.B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Natural behavior polymorphism due to a cGMP-dependent protein kinase of Drosophila</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1997-08-08</date><risdate>1997</risdate><volume>277</volume><issue>5327</issue><spage>834</spage><epage>836</epage><pages>834-836</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>Naturally occuring polymorphisms in behavior are dlfficult to map genetically and thus are refractory to molecular characterization. An exception is the foraging gene (for), a gene that has two naturally occurring variants in Drosophila melanogaster food-search behavior: rover and sitter. Molecular mapping placed for mutations in the dg2 gene, which encodes a cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG). Rovers had higher PKG activity than sitters, and transgenic sitters expressing a dg2 comlementary DNA from rover showed transformation of behavior to rover. Thus, PKG levels affected food-search behavior, and natural variation in PKG activity accounted for a behavioral polymorphism</abstract><cop>Washington, DC</cop><pub>American Society for the Advancement of Science</pub><pmid>9242616</pmid><doi>10.1126/science.277.5327.834</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1997-08, Vol.277 (5327), p.834-836 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79177887 |
| source | American Association for the Advancement of Science; Jstor Complete Legacy; MEDLINE |
| subjects | Alleles Anatomy Animal behavior Animals Animals, Genetically Modified Associative Learning Behavior BEHAVIOR PATTERNS BEHAVIOUR Biological and medical sciences Classical genetics, quantitative genetics, hybrids COMPORTAMIENTO COMPORTEMENT Cyclic GMP - metabolism Cyclic GMP-Dependent Protein Kinases - genetics Cyclic GMP-Dependent Protein Kinases - metabolism Drosophila DROSOPHILA MELANOGASTER Drosophila melanogaster - genetics Drosophila melanogaster - physiology Feeding Behavior Foraging Fruit-flies Fundamental and applied biological sciences. Psychology Genes Genes, Insect Genetic aspects Genetic mutation GENETIC POLYMORPHISM Genetics Genetics of eukaryotes. Biological and molecular evolution Insect larvae Insects Invertebrata Larva - genetics Larva - physiology Larvae Mutation Neurons Phenotype POLIMORFISMO GENETICO Polymorphism, Genetic POLYMORPHISME GENETIQUE PROTEIN KINASE PROTEINA QUINASA PROTEINE KINASE Proteins RNA SEARCHING BEHAVIOR Shock heating Signal Transduction Transgenic animals |
| title | Natural behavior polymorphism due to a cGMP-dependent protein kinase of Drosophila |
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