Energetically Unfavorable Interactions among the Zinc Fingers of Transcription Factor IIIA When Bound to the 5 S rRNA Gene

Xenopus transcription factor IIIA (TFIIIA) binds to over 50 base pairs in the internal control region of the 5 S rRNA gene, yet the binding energy for this interaction (ΔG0 = −12.8 kcal/mol) is no greater than that exhibited by many proteins that occupy much smaller DNA targets. Despite considerable...

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Veröffentlicht in:	The Journal of biological chemistry 1997-08, Vol.272 (32), p.20152-20161
Hauptverfasser:	Kehres, David G., Subramanyan, Girish S., Hung, Virginia S., Rogers, George W., Setzer, David R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Deoxyribonuclease I - metabolism DNA - metabolism DNA-Binding Proteins - metabolism Evolution, Molecular Kinetics RNA, Ribosomal, 5S - genetics Thermodynamics Transcription Factor TFIIIA Transcription Factors - metabolism Xenopus Zinc Fingers
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