Immunologic Memory Induced at Birth by Immunization with Inactivated Polio Vaccine in a Reduced Schedule
One hundred forty-one healthy newborns were immunized 24 hours after birth with one dose of inactivated polio vaccine (IPV) of enhanced potency. Following the administration of a second vaccine dose six months later, a considerable proportion of babies responded with neutralizing antibody (NA) to th...
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| Veröffentlicht in: | European journal of epidemiology 1989-06, Vol.5 (2), p.143-145 |
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| container_end_page | 145 |
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| container_issue | 2 |
| container_start_page | 143 |
| container_title | European journal of epidemiology |
| container_volume | 5 |
| creator | Swartz, T. A. Handsher, R. Stoeckel, P. Drucker, J. Caudrelier, P. Van Wezel, A. L. Cohen, H. Salk, D. Salk, J. |
| description | One hundred forty-one healthy newborns were immunized 24 hours after birth with one dose of inactivated polio vaccine (IPV) of enhanced potency. Following the administration of a second vaccine dose six months later, a considerable proportion of babies responded with neutralizing antibody (NA) to the three poliovirus types. The very rapid occurrence and high antibody titer were indicative of an anamnestic response. Twenty-one infants who still had NA < 1:4 to one-more poliovirus types after the second vaccine dose responded with very high NA values 7-10 days after a supplementary dose of IPV. It appears that IPV of enhanced potency administered at birth is apt to induce immunologic memory, which should provide the basis for protection against paralytic poliomyelitis in case of exposure to wild poliovirus later in life. |
| doi_str_mv | 10.1007/BF00156819 |
| format | Article |
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A. ; Handsher, R. ; Stoeckel, P. ; Drucker, J. ; Caudrelier, P. ; Van Wezel, A. L. ; Cohen, H. ; Salk, D. ; Salk, J.</creator><creatorcontrib>Swartz, T. A. ; Handsher, R. ; Stoeckel, P. ; Drucker, J. ; Caudrelier, P. ; Van Wezel, A. L. ; Cohen, H. ; Salk, D. ; Salk, J.</creatorcontrib><description>One hundred forty-one healthy newborns were immunized 24 hours after birth with one dose of inactivated polio vaccine (IPV) of enhanced potency. Following the administration of a second vaccine dose six months later, a considerable proportion of babies responded with neutralizing antibody (NA) to the three poliovirus types. The very rapid occurrence and high antibody titer were indicative of an anamnestic response. Twenty-one infants who still had NA < 1:4 to one-more poliovirus types after the second vaccine dose responded with very high NA values 7-10 days after a supplementary dose of IPV. It appears that IPV of enhanced potency administered at birth is apt to induce immunologic memory, which should provide the basis for protection against paralytic poliomyelitis in case of exposure to wild poliovirus later in life.</description><identifier>ISSN: 0393-2990</identifier><identifier>EISSN: 1573-7284</identifier><identifier>DOI: 10.1007/BF00156819</identifier><identifier>PMID: 2767220</identifier><language>eng</language><publisher>Netherlands: Kluwer Academic Publishers</publisher><subject>Dosage ; Geometric mean ; Humans ; Immunization ; Immunization Schedule ; Immunologic Memory ; Inactivated poliovirus vaccine ; Infant, Newborn - immunology ; Infants ; Neutralizing antibodies ; Poliomyelitis ; Poliovirus ; Poliovirus Vaccine, Inactivated - administration & dosage ; Serologic Tests ; Vaccination ; Vaccines, Inactivated - administration & dosage</subject><ispartof>European journal of epidemiology, 1989-06, Vol.5 (2), p.143-145</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c218t-b85b60b3c4bbf51036d329122665a25d3570afa7e8e2abd4275e18ea5ab3dd153</citedby><cites>FETCH-LOGICAL-c218t-b85b60b3c4bbf51036d329122665a25d3570afa7e8e2abd4275e18ea5ab3dd153</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3520513$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3520513$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2767220$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Swartz, T. A.</creatorcontrib><creatorcontrib>Handsher, R.</creatorcontrib><creatorcontrib>Stoeckel, P.</creatorcontrib><creatorcontrib>Drucker, J.</creatorcontrib><creatorcontrib>Caudrelier, P.</creatorcontrib><creatorcontrib>Van Wezel, A. L.</creatorcontrib><creatorcontrib>Cohen, H.</creatorcontrib><creatorcontrib>Salk, D.</creatorcontrib><creatorcontrib>Salk, J.</creatorcontrib><title>Immunologic Memory Induced at Birth by Immunization with Inactivated Polio Vaccine in a Reduced Schedule</title><title>European journal of epidemiology</title><addtitle>Eur J Epidemiol</addtitle><description>One hundred forty-one healthy newborns were immunized 24 hours after birth with one dose of inactivated polio vaccine (IPV) of enhanced potency. Following the administration of a second vaccine dose six months later, a considerable proportion of babies responded with neutralizing antibody (NA) to the three poliovirus types. The very rapid occurrence and high antibody titer were indicative of an anamnestic response. Twenty-one infants who still had NA < 1:4 to one-more poliovirus types after the second vaccine dose responded with very high NA values 7-10 days after a supplementary dose of IPV. It appears that IPV of enhanced potency administered at birth is apt to induce immunologic memory, which should provide the basis for protection against paralytic poliomyelitis in case of exposure to wild poliovirus later in life.</description><subject>Dosage</subject><subject>Geometric mean</subject><subject>Humans</subject><subject>Immunization</subject><subject>Immunization Schedule</subject><subject>Immunologic Memory</subject><subject>Inactivated poliovirus vaccine</subject><subject>Infant, Newborn - immunology</subject><subject>Infants</subject><subject>Neutralizing antibodies</subject><subject>Poliomyelitis</subject><subject>Poliovirus</subject><subject>Poliovirus Vaccine, Inactivated - administration & dosage</subject><subject>Serologic Tests</subject><subject>Vaccination</subject><subject>Vaccines, Inactivated - administration & dosage</subject><issn>0393-2990</issn><issn>1573-7284</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM9LwzAYhoMoc04vnhVy8iBUvyRL0x7dcDpQFH9dS5KmLqNtZtIq86-3o2Oevo_3eXgPL0KnBK4IgLiezAAIjxOS7qEh4YJFgibjfTQElrKIpikcoqMQlgCQQMoHaEBFLCiFIVrMq6qtXek-rcaPpnJ-jed13mqTY9ngifXNAqsu22j2VzbW1fjHduG8lrqx37LpzGdXWoc_pNa2NtjWWOIX05e86kX3leYYHRSyDOZke0fofXb7Nr2PHp7u5tObh0hTkjSRSriKQTE9VqrgBFicM5oSSuOYS8pzxgXIQgqTGCpVPqaCG5IYyaVieU44G6GLvnfl3VdrQpNVNmhTlrI2rg2ZSImIiSCdeNmL2rsQvCmylbeV9OuMQLaZNfuftZPPt62tqky-U7c7dvys58vQOL_DjFPghLE_ftx7hQ</recordid><startdate>19890601</startdate><enddate>19890601</enddate><creator>Swartz, T. A.</creator><creator>Handsher, R.</creator><creator>Stoeckel, P.</creator><creator>Drucker, J.</creator><creator>Caudrelier, P.</creator><creator>Van Wezel, A. L.</creator><creator>Cohen, H.</creator><creator>Salk, D.</creator><creator>Salk, J.</creator><general>Kluwer Academic Publishers</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19890601</creationdate><title>Immunologic Memory Induced at Birth by Immunization with Inactivated Polio Vaccine in a Reduced Schedule</title><author>Swartz, T. A. ; Handsher, R. ; Stoeckel, P. ; Drucker, J. ; Caudrelier, P. ; Van Wezel, A. L. ; Cohen, H. ; Salk, D. ; Salk, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c218t-b85b60b3c4bbf51036d329122665a25d3570afa7e8e2abd4275e18ea5ab3dd153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Dosage</topic><topic>Geometric mean</topic><topic>Humans</topic><topic>Immunization</topic><topic>Immunization Schedule</topic><topic>Immunologic Memory</topic><topic>Inactivated poliovirus vaccine</topic><topic>Infant, Newborn - immunology</topic><topic>Infants</topic><topic>Neutralizing antibodies</topic><topic>Poliomyelitis</topic><topic>Poliovirus</topic><topic>Poliovirus Vaccine, Inactivated - administration & dosage</topic><topic>Serologic Tests</topic><topic>Vaccination</topic><topic>Vaccines, Inactivated - administration & dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Swartz, T. A.</creatorcontrib><creatorcontrib>Handsher, R.</creatorcontrib><creatorcontrib>Stoeckel, P.</creatorcontrib><creatorcontrib>Drucker, J.</creatorcontrib><creatorcontrib>Caudrelier, P.</creatorcontrib><creatorcontrib>Van Wezel, A. L.</creatorcontrib><creatorcontrib>Cohen, H.</creatorcontrib><creatorcontrib>Salk, D.</creatorcontrib><creatorcontrib>Salk, J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of epidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Swartz, T. A.</au><au>Handsher, R.</au><au>Stoeckel, P.</au><au>Drucker, J.</au><au>Caudrelier, P.</au><au>Van Wezel, A. L.</au><au>Cohen, H.</au><au>Salk, D.</au><au>Salk, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunologic Memory Induced at Birth by Immunization with Inactivated Polio Vaccine in a Reduced Schedule</atitle><jtitle>European journal of epidemiology</jtitle><addtitle>Eur J Epidemiol</addtitle><date>1989-06-01</date><risdate>1989</risdate><volume>5</volume><issue>2</issue><spage>143</spage><epage>145</epage><pages>143-145</pages><issn>0393-2990</issn><eissn>1573-7284</eissn><abstract>One hundred forty-one healthy newborns were immunized 24 hours after birth with one dose of inactivated polio vaccine (IPV) of enhanced potency. Following the administration of a second vaccine dose six months later, a considerable proportion of babies responded with neutralizing antibody (NA) to the three poliovirus types. The very rapid occurrence and high antibody titer were indicative of an anamnestic response. Twenty-one infants who still had NA < 1:4 to one-more poliovirus types after the second vaccine dose responded with very high NA values 7-10 days after a supplementary dose of IPV. It appears that IPV of enhanced potency administered at birth is apt to induce immunologic memory, which should provide the basis for protection against paralytic poliomyelitis in case of exposure to wild poliovirus later in life.</abstract><cop>Netherlands</cop><pub>Kluwer Academic Publishers</pub><pmid>2767220</pmid><doi>10.1007/BF00156819</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0393-2990 |
| ispartof | European journal of epidemiology, 1989-06, Vol.5 (2), p.143-145 |
| issn | 0393-2990 1573-7284 |
| language | eng |
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| source | Jstor Complete Legacy; MEDLINE; SpringerLink Journals |
| subjects | Dosage Geometric mean Humans Immunization Immunization Schedule Immunologic Memory Inactivated poliovirus vaccine Infant, Newborn - immunology Infants Neutralizing antibodies Poliomyelitis Poliovirus Poliovirus Vaccine, Inactivated - administration & dosage Serologic Tests Vaccination Vaccines, Inactivated - administration & dosage |
| title | Immunologic Memory Induced at Birth by Immunization with Inactivated Polio Vaccine in a Reduced Schedule |
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