Specific detection of an interleukin 1- and tumour necrosis factor-activated beta-casein kinase in HeLa and KB cells

Interleukin 1 (IL-1) and tumour necrosis factor (TNF) activate a novel protein kinase, TIP kinase, which phosphorylates beta-casein in vitro. We have identified and purified to homogeneity a tryptic fragment of beta-casein, called T1, which was phosphorylated by TIP kinase with kinetics similar to t...

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Veröffentlicht in:	Cytokine (Philadelphia, Pa.) Pa.), 1997-07, Vol.9 (7), p.471-479
Hauptverfasser:	Guesdon, F, Waller, R J, Saklatvala, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Casein Kinases Caseins - metabolism Electrophoresis, Gel, Two-Dimensional Endopeptidases - metabolism Enzyme Activation HeLa Cells Humans Interleukin-1 - pharmacology KB Cells Peptide Mapping Phosphorylation Protein Kinases - metabolism Substrate Specificity Tumor Necrosis Factor-alpha - pharmacology
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