Is Natural Infection with M. tuberculosis Protective against Cancer?
In order to investigate the effect of natural infection with M. tuberculosis on cancer incidence, a case-control study was undertaken on 108 recently diagnosed cancer cases (all sites) and 317 controls. After removal of cancer cases or controls considered immunoincompetent (25% and 17% respectively)...
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| Veröffentlicht in: | European journal of epidemiology 1989-06, Vol.5 (2), p.234-238 |
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| container_title | European journal of epidemiology |
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| creator | Fragoulia, A. Kondakis, X. G. Dimopoulos, I. |
| description | In order to investigate the effect of natural infection with M. tuberculosis on cancer incidence, a case-control study was undertaken on 108 recently diagnosed cancer cases (all sites) and 317 controls. After removal of cancer cases or controls considered immunoincompetent (25% and 17% respectively), the remaining subjects were tested by intradermal injection of tuberculin (5 I.U.). Results were compared separately for each sex. It was observed that the proportion of tuberculin-negative subjects was higher in cancer patients than in controls within each sex (males 31.3% vs 20.1%, females: 59.2% vs 37.3%) the difference in females being statistically significant (p < 0.02). Odds ratio for negative tuberculin test was 1.80 and 2.44 for males and females respectively. The results are discussed on the basis of cell-mediated immunity produced by infection with M. tuberculosis and its relations with tumor growth. |
| doi_str_mv | 10.1007/bf00156837 |
| format | Article |
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G.</creatorcontrib><creatorcontrib>Dimopoulos, I.</creatorcontrib><title>Is Natural Infection with M. tuberculosis Protective against Cancer?</title><title>European journal of epidemiology</title><addtitle>Eur J Epidemiol</addtitle><description>In order to investigate the effect of natural infection with M. tuberculosis on cancer incidence, a case-control study was undertaken on 108 recently diagnosed cancer cases (all sites) and 317 controls. After removal of cancer cases or controls considered immunoincompetent (25% and 17% respectively), the remaining subjects were tested by intradermal injection of tuberculin (5 I.U.). Results were compared separately for each sex. It was observed that the proportion of tuberculin-negative subjects was higher in cancer patients than in controls within each sex (males 31.3% vs 20.1%, females: 59.2% vs 37.3%) the difference in females being statistically significant (p < 0.02). Odds ratio for negative tuberculin test was 1.80 and 2.44 for males and females respectively. The results are discussed on the basis of cell-mediated immunity produced by infection with M. tuberculosis and its relations with tumor growth.</description><subject>Cancer</subject><subject>Cohort Studies</subject><subject>Demography</subject><subject>Etiology</subject><subject>Europe</subject><subject>Female</subject><subject>Humans</subject><subject>Infections</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Mycobacterium tuberculosis</subject><subject>Neoplasms - complications</subject><subject>Neoplasms - mortality</subject><subject>Neoplasms - prevention & control</subject><subject>Pulmonary tuberculosis</subject><subject>Random Allocation</subject><subject>Risk Factors</subject><subject>Skin Tests</subject><subject>Tuberculin</subject><subject>Tuberculin test</subject><subject>Tuberculosis</subject><subject>Tuberculosis - complications</subject><subject>Tuberculosis - epidemiology</subject><subject>Tumors</subject><issn>0393-2990</issn><issn>0392-2990</issn><issn>1573-7284</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kDtPwzAYRS0EKqWwMIPkiQEp5fM7mRAUCpXKY-geOY4NqdKk2A6If0-qlk53OEdnuAidExgTAHVTOAAiZMrUARoSoViiaMoP0RBYxhKaZXCMTkJYAkAKmRigAVVSUcaG6GEW8KuOndc1njXOmli1Df6p4id-GePYFdabrm5DFfC7b-OGf1usP3TVhIgnujHW356iI6frYM92O0KL6eNi8pzM355mk7t5YhijMXGGS1VyDWkJUhhlCS1LR7mytshKxwsp0oLxlApwRGpOBPDCCcJA277ARuhqm1379quzIearKhhb17qxbRdylRHFJaW9eL0VjW9D8Nbla1-ttP_NCeSbx_L76f9jvXy5q3bFypZ7dXdRzy-2fBli6_eYCQqCEfYHNapuSQ</recordid><startdate>19890601</startdate><enddate>19890601</enddate><creator>Fragoulia, A.</creator><creator>Kondakis, X. G.</creator><creator>Dimopoulos, I.</creator><general>Kluwer Academic Publishers</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19890601</creationdate><title>Is Natural Infection with M. tuberculosis Protective against Cancer?</title><author>Fragoulia, A. ; Kondakis, X. G. ; Dimopoulos, I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c332t-fc467d4a08d065c7e12ddf247eeb9df4b658b348250f16a41504bf5130aec333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Cancer</topic><topic>Cohort Studies</topic><topic>Demography</topic><topic>Etiology</topic><topic>Europe</topic><topic>Female</topic><topic>Humans</topic><topic>Infections</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Mycobacterium tuberculosis</topic><topic>Neoplasms - complications</topic><topic>Neoplasms - mortality</topic><topic>Neoplasms - prevention & control</topic><topic>Pulmonary tuberculosis</topic><topic>Random Allocation</topic><topic>Risk Factors</topic><topic>Skin Tests</topic><topic>Tuberculin</topic><topic>Tuberculin test</topic><topic>Tuberculosis</topic><topic>Tuberculosis - complications</topic><topic>Tuberculosis - epidemiology</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fragoulia, A.</creatorcontrib><creatorcontrib>Kondakis, X. 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It was observed that the proportion of tuberculin-negative subjects was higher in cancer patients than in controls within each sex (males 31.3% vs 20.1%, females: 59.2% vs 37.3%) the difference in females being statistically significant (p < 0.02). Odds ratio for negative tuberculin test was 1.80 and 2.44 for males and females respectively. The results are discussed on the basis of cell-mediated immunity produced by infection with M. tuberculosis and its relations with tumor growth.</abstract><cop>Netherlands</cop><pub>Kluwer Academic Publishers</pub><pmid>2767233</pmid><doi>10.1007/bf00156837</doi><tpages>5</tpages></addata></record> |
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| ispartof | European journal of epidemiology, 1989-06, Vol.5 (2), p.234-238 |
| issn | 0393-2990 0392-2990 1573-7284 |
| language | eng |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; SpringerLink Journals - AutoHoldings |
| subjects | Cancer Cohort Studies Demography Etiology Europe Female Humans Infections Male Middle Aged Mortality Mycobacterium tuberculosis Neoplasms - complications Neoplasms - mortality Neoplasms - prevention & control Pulmonary tuberculosis Random Allocation Risk Factors Skin Tests Tuberculin Tuberculin test Tuberculosis Tuberculosis - complications Tuberculosis - epidemiology Tumors |
| title | Is Natural Infection with M. tuberculosis Protective against Cancer? |
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