Nitric oxide inhibition simulates the enhancement of alpha 1 agonist-induced vasoconstriction in diabetes

We have previously reported that endothelium-dependent, nitric oxide (NO)-mediated vasorelaxation is impaired in diabetic mesenteric arteries. We hypothesized that vasoconstrictor responses should therefore be enhanced. The purpose of this study was to determine whether diabetic mesenteric arteries...

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Veröffentlicht in:	The Journal of surgical research 1997-07, Vol.70 (2), p.119-123
Hauptverfasser:	Dresner, L S, Wang, S P, West, M W, Ponomarenko, I N, Mueller, C M, Wait, R B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic alpha-Agonists - pharmacology Animals Brimonidine Tartrate Diabetes Mellitus, Experimental - physiopathology In Vitro Techniques Male Mesenteric Arteries - drug effects NG-Nitroarginine Methyl Ester - pharmacology Nitric Oxide - antagonists & inhibitors Nitric Oxide Synthase - antagonists & inhibitors Phenylephrine - pharmacology Quinoxalines - pharmacology Rats Rats, Sprague-Dawley Vasoconstriction - drug effects
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