Inducible Macrophage Apoptosis Following Sepsis Is Mediated by Cysteine Protease Activation and Nitric Oxide Release

Recent studies indicate that polymicrobial sepsis can markedly increase inducible macrophage Ao(nonnecrotic cellular suicide) and that this is associated with decreased Mφ function.In vitrostudies suggest that Mφ Aocan be induced by IL-1β via interleukin-1β-converting enzyme (ICE, a cysteine proteas...

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Veröffentlicht in:	The Journal of surgical research 1997-07, Vol.70 (2), p.113-118
Hauptverfasser:	Williams, Todd E., Ayala, Alfred, Chaudry, Irshad H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal infectious diseases Animals Apoptosis Biological and medical sciences Cecum - injuries Cells, Cultured Cysteine Endopeptidases - metabolism Cysteine Proteinase Inhibitors - pharmacology DNA Fragmentation General aspects Infectious diseases Interleukin-6 - metabolism Intestinal Diseases - pathology Iodoacetamide - pharmacology Macrophages - cytology Macrophages, Peritoneal - cytology Male Medical sciences Mice Mice, Inbred C3H Nitric Oxide - antagonists & inhibitors Nitric Oxide - metabolism Nitric Oxide Synthase - antagonists & inhibitors Sepsis - pathology
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