Expression of c-Myc, TGF-α and EGF-Receptor in Sporadic Medullary Thyroid Carcinoma
In 20 patients with sporadic medullary thyroid carcinoma (MTC), immuno-histochemistry was used to localize the expression of the c-Myc oncoprotein, transforming growth factor alpha (TGF-α) and epidermal growth factor receptor (EGFR) and these three markers were analysed regarding their relation to h...
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| Veröffentlicht in: | Acta oncologica 1997, Vol.36 (4), p.407-411 |
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| creator | Wang, Wenliang Johansson, Henry E. Bergholm, Ulla I. Westermark, Kerstin M. Grimelius, Lars E. |
| description | In 20 patients with sporadic medullary thyroid carcinoma (MTC), immuno-histochemistry was used to localize the expression of the c-Myc oncoprotein, transforming growth factor alpha (TGF-α) and epidermal growth factor receptor (EGFR) and these three markers were analysed regarding their relation to histopathological and histochemical variables of the tumours. The detection rates of c-Myc. TGF-α and EGFR were 90%, 90% and 95% respectively. Concomitant demonstration of the markers was reflected in significant associations (correlation factor between TGF-α and EGFR was 0.93, p < 0.001). The markers were almost invariably located within the cytoplasm, which might suggest their crucial role in growth regulation and cell differentiation; this seems especially true of TGF-α and EGFR. The different markers showed no relation to either histopathological or histochemical variables (tumour behaviour, tumour size, tumour cell type). The prominent co-expression of c-Myc, TGF-α and EGFR proteins indicates that in MTC these factors might be of importance for tumour cell proliferation via autocrine growth stimulation. |
| doi_str_mv | 10.3109/02841869709001288 |
| format | Article |
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The detection rates of c-Myc. TGF-α and EGFR were 90%, 90% and 95% respectively. Concomitant demonstration of the markers was reflected in significant associations (correlation factor between TGF-α and EGFR was 0.93, p < 0.001). The markers were almost invariably located within the cytoplasm, which might suggest their crucial role in growth regulation and cell differentiation; this seems especially true of TGF-α and EGFR. The different markers showed no relation to either histopathological or histochemical variables (tumour behaviour, tumour size, tumour cell type). The prominent co-expression of c-Myc, TGF-α and EGFR proteins indicates that in MTC these factors might be of importance for tumour cell proliferation via autocrine growth stimulation.</description><identifier>ISSN: 0284-186X</identifier><identifier>EISSN: 1651-226X</identifier><identifier>DOI: 10.3109/02841869709001288</identifier><identifier>PMID: 9247102</identifier><identifier>CODEN: ACTOEL</identifier><language>eng</language><publisher>Basingstoke: Informa UK Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Biomarkers, Tumor - analysis ; Biomarkers, Tumor - genetics ; Carcinoma, Medullary - pathology ; Cell Differentiation ; Cell Division ; Cell Membrane - ultrastructure ; Coloring Agents ; Cytoplasm - ultrastructure ; Disease-Free Survival ; Endocrinopathies ; ErbB Receptors - analysis ; ErbB Receptors - genetics ; Female ; Follow-Up Studies ; Gene Expression Regulation, Neoplastic ; Humans ; Immunohistochemistry ; Inclusion Bodies - ultrastructure ; Male ; Malignant tumors ; Medical sciences ; Middle Aged ; Nuclear Envelope - ultrastructure ; Proto-Oncogene Proteins c-myc - analysis ; Proto-Oncogene Proteins c-myc - genetics ; Survival Rate ; Thyroid Neoplasms - pathology ; Thyroid. Thyroid axis (diseases) ; Transforming Growth Factor alpha - analysis ; Transforming Growth Factor alpha - genetics</subject><ispartof>Acta oncologica, 1997, Vol.36 (4), p.407-411</ispartof><rights>1997 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1997</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c377t-4d2acd36d1fc55157c98a4917949386fdcf699315a3b035e272c4b87a8e101bb3</citedby><cites>FETCH-LOGICAL-c377t-4d2acd36d1fc55157c98a4917949386fdcf699315a3b035e272c4b87a8e101bb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/02841869709001288$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/02841869709001288$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,776,780,4010,27902,27903,27904,61196,61377</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2736629$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9247102$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Wenliang</creatorcontrib><creatorcontrib>Johansson, Henry E.</creatorcontrib><creatorcontrib>Bergholm, Ulla I.</creatorcontrib><creatorcontrib>Westermark, Kerstin M.</creatorcontrib><creatorcontrib>Grimelius, Lars E.</creatorcontrib><title>Expression of c-Myc, TGF-α and EGF-Receptor in Sporadic Medullary Thyroid Carcinoma</title><title>Acta oncologica</title><addtitle>Acta Oncol</addtitle><description>In 20 patients with sporadic medullary thyroid carcinoma (MTC), immuno-histochemistry was used to localize the expression of the c-Myc oncoprotein, transforming growth factor alpha (TGF-α) and epidermal growth factor receptor (EGFR) and these three markers were analysed regarding their relation to histopathological and histochemical variables of the tumours. The detection rates of c-Myc. TGF-α and EGFR were 90%, 90% and 95% respectively. Concomitant demonstration of the markers was reflected in significant associations (correlation factor between TGF-α and EGFR was 0.93, p < 0.001). The markers were almost invariably located within the cytoplasm, which might suggest their crucial role in growth regulation and cell differentiation; this seems especially true of TGF-α and EGFR. The different markers showed no relation to either histopathological or histochemical variables (tumour behaviour, tumour size, tumour cell type). The prominent co-expression of c-Myc, TGF-α and EGFR proteins indicates that in MTC these factors might be of importance for tumour cell proliferation via autocrine growth stimulation.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Carcinoma, Medullary - pathology</subject><subject>Cell Differentiation</subject><subject>Cell Division</subject><subject>Cell Membrane - ultrastructure</subject><subject>Coloring Agents</subject><subject>Cytoplasm - ultrastructure</subject><subject>Disease-Free Survival</subject><subject>Endocrinopathies</subject><subject>ErbB Receptors - analysis</subject><subject>ErbB Receptors - genetics</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Inclusion Bodies - ultrastructure</subject><subject>Male</subject><subject>Malignant tumors</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nuclear Envelope - ultrastructure</subject><subject>Proto-Oncogene Proteins c-myc - analysis</subject><subject>Proto-Oncogene Proteins c-myc - genetics</subject><subject>Survival Rate</subject><subject>Thyroid Neoplasms - pathology</subject><subject>Thyroid. Thyroid axis (diseases)</subject><subject>Transforming Growth Factor alpha - analysis</subject><subject>Transforming Growth Factor alpha - genetics</subject><issn>0284-186X</issn><issn>1651-226X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kN9KwzAYxYMoc04fwAshF-KV1fxpmwavZGxTcAg6YXclTVKW0TY1acE9li_iM5mxsRvBq--D8zuHwwHgEqM7ihG_RySLcZZyhjhCmGTZERjiNMERIenyGAy3ehSA5Sk4836NECKUJQMw4CRmGJEhWEy-Wqe9N7aBtoQymm_kLVzMptHPNxSNgpPwvmmp2846aBr43lonlJFwrlVfVcJt4GK1cdYoOBZOmsbW4hyclKLy-mJ_R-BjOlmMn6KX19nz-PElkpSxLooVEVLRVOFSJglOmOSZiDlmPOY0S0sly5RzihNBC0QTTRiRcZExkWmMcFHQEbjZ5bbOfvbad3ltvNShVaNt73MWsihJcADxDpTOeu90mbfO1KF7jlG-XTL_s2TwXO3D-6LW6uDYTxf0670uvBRV6UQjjT9ghNE0JTxgDzvMNKV1tVhpUXUrKZzO17Z3TdjnnxK_wbmMCQ</recordid><startdate>1997</startdate><enddate>1997</enddate><creator>Wang, Wenliang</creator><creator>Johansson, Henry E.</creator><creator>Bergholm, Ulla I.</creator><creator>Westermark, Kerstin M.</creator><creator>Grimelius, Lars E.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1997</creationdate><title>Expression of c-Myc, TGF-α and EGF-Receptor in Sporadic Medullary Thyroid Carcinoma</title><author>Wang, Wenliang ; Johansson, Henry E. ; Bergholm, Ulla I. ; Westermark, Kerstin M. ; Grimelius, Lars E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c377t-4d2acd36d1fc55157c98a4917949386fdcf699315a3b035e272c4b87a8e101bb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Carcinoma, Medullary - pathology</topic><topic>Cell Differentiation</topic><topic>Cell Division</topic><topic>Cell Membrane - ultrastructure</topic><topic>Coloring Agents</topic><topic>Cytoplasm - ultrastructure</topic><topic>Disease-Free Survival</topic><topic>Endocrinopathies</topic><topic>ErbB Receptors - analysis</topic><topic>ErbB Receptors - genetics</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Inclusion Bodies - ultrastructure</topic><topic>Male</topic><topic>Malignant tumors</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nuclear Envelope - ultrastructure</topic><topic>Proto-Oncogene Proteins c-myc - analysis</topic><topic>Proto-Oncogene Proteins c-myc - genetics</topic><topic>Survival Rate</topic><topic>Thyroid Neoplasms - pathology</topic><topic>Thyroid. Thyroid axis (diseases)</topic><topic>Transforming Growth Factor alpha - analysis</topic><topic>Transforming Growth Factor alpha - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Wenliang</creatorcontrib><creatorcontrib>Johansson, Henry E.</creatorcontrib><creatorcontrib>Bergholm, Ulla I.</creatorcontrib><creatorcontrib>Westermark, Kerstin M.</creatorcontrib><creatorcontrib>Grimelius, Lars E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta oncologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Wenliang</au><au>Johansson, Henry E.</au><au>Bergholm, Ulla I.</au><au>Westermark, Kerstin M.</au><au>Grimelius, Lars E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of c-Myc, TGF-α and EGF-Receptor in Sporadic Medullary Thyroid Carcinoma</atitle><jtitle>Acta oncologica</jtitle><addtitle>Acta Oncol</addtitle><date>1997</date><risdate>1997</risdate><volume>36</volume><issue>4</issue><spage>407</spage><epage>411</epage><pages>407-411</pages><issn>0284-186X</issn><eissn>1651-226X</eissn><coden>ACTOEL</coden><abstract>In 20 patients with sporadic medullary thyroid carcinoma (MTC), immuno-histochemistry was used to localize the expression of the c-Myc oncoprotein, transforming growth factor alpha (TGF-α) and epidermal growth factor receptor (EGFR) and these three markers were analysed regarding their relation to histopathological and histochemical variables of the tumours. The detection rates of c-Myc. TGF-α and EGFR were 90%, 90% and 95% respectively. Concomitant demonstration of the markers was reflected in significant associations (correlation factor between TGF-α and EGFR was 0.93, p < 0.001). The markers were almost invariably located within the cytoplasm, which might suggest their crucial role in growth regulation and cell differentiation; this seems especially true of TGF-α and EGFR. The different markers showed no relation to either histopathological or histochemical variables (tumour behaviour, tumour size, tumour cell type). The prominent co-expression of c-Myc, TGF-α and EGFR proteins indicates that in MTC these factors might be of importance for tumour cell proliferation via autocrine growth stimulation.</abstract><cop>Basingstoke</cop><pub>Informa UK Ltd</pub><pmid>9247102</pmid><doi>10.3109/02841869709001288</doi><tpages>5</tpages></addata></record> |
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| ispartof | Acta oncologica, 1997, Vol.36 (4), p.407-411 |
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| source | Taylor & Francis; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adolescent Adult Aged Aged, 80 and over Biological and medical sciences Biomarkers, Tumor - analysis Biomarkers, Tumor - genetics Carcinoma, Medullary - pathology Cell Differentiation Cell Division Cell Membrane - ultrastructure Coloring Agents Cytoplasm - ultrastructure Disease-Free Survival Endocrinopathies ErbB Receptors - analysis ErbB Receptors - genetics Female Follow-Up Studies Gene Expression Regulation, Neoplastic Humans Immunohistochemistry Inclusion Bodies - ultrastructure Male Malignant tumors Medical sciences Middle Aged Nuclear Envelope - ultrastructure Proto-Oncogene Proteins c-myc - analysis Proto-Oncogene Proteins c-myc - genetics Survival Rate Thyroid Neoplasms - pathology Thyroid. Thyroid axis (diseases) Transforming Growth Factor alpha - analysis Transforming Growth Factor alpha - genetics |
| title | Expression of c-Myc, TGF-α and EGF-Receptor in Sporadic Medullary Thyroid Carcinoma |
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