Robertsonian translocations in Paget's disease of bone
The karyotypes of 14 patients with Paget's disease of bone were studied. The patients were recruited from our bone metabolism clinic where they received specific therapy for their skeletal disease. Eight of the 14 patients had chromosomal translocations localized to the D and G groups. None of...
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| Veröffentlicht in: | Journal of orthopaedic research 1997-05, Vol.15 (3), p.477-481 |
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| container_title | Journal of orthopaedic research |
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| creator | Mills, Barbara G. Oizumi, Jun Kudo, Emily Rude, Robert |
| description | The karyotypes of 14 patients with Paget's disease of bone were studied. The patients were recruited from our bone metabolism clinic where they received specific therapy for their skeletal disease. Eight of the 14 patients had chromosomal translocations localized to the D and G groups. None of the patients were related to one another, nor had any had the same lifelong environment. Thus, 57% of a sample of active patients with Paget's disease had Robertsonian translocations. By comparison, an age and sex‐matched group of eight controls and 13 patients with osteoporosis who had been treated with bisphosphonates demonstrated no Robertsonian translocations. The prevalence of Robertsonian translocations in 14,000 newborns was reported to be 0.1%. These data suggest that a factor from the environment introduced during the lifetime of the patient could be present and could, in addition to genetic factors, affect gene replication during the development of Paget's disease. |
| doi_str_mv | 10.1002/jor.1100150324 |
| format | Article |
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The patients were recruited from our bone metabolism clinic where they received specific therapy for their skeletal disease. Eight of the 14 patients had chromosomal translocations localized to the D and G groups. None of the patients were related to one another, nor had any had the same lifelong environment. Thus, 57% of a sample of active patients with Paget's disease had Robertsonian translocations. By comparison, an age and sex‐matched group of eight controls and 13 patients with osteoporosis who had been treated with bisphosphonates demonstrated no Robertsonian translocations. The prevalence of Robertsonian translocations in 14,000 newborns was reported to be 0.1%. These data suggest that a factor from the environment introduced during the lifetime of the patient could be present and could, in addition to genetic factors, affect gene replication during the development of Paget's disease.</description><identifier>ISSN: 0736-0266</identifier><identifier>EISSN: 1554-527X</identifier><identifier>DOI: 10.1002/jor.1100150324</identifier><identifier>PMID: 9246098</identifier><identifier>CODEN: JOREDR</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Aged ; Aged, 80 and over ; Chromosomes, Human, Pair 13 ; Chromosomes, Human, Pair 14 ; Chromosomes, Human, Pair 15 ; Diseases ; Female ; Genes ; Humans ; Karyotyping ; Male ; Metabolism ; Middle Aged ; Osteitis Deformans - genetics ; Phenotype ; Translocation, Genetic</subject><ispartof>Journal of orthopaedic research, 1997-05, Vol.15 (3), p.477-481</ispartof><rights>Copyright © 1997 Orthopaedic Research Society</rights><rights>Copyright Journal of Bone and Joint Surgery, Inc. May 1997</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3914-6b00b3875cab841111cb93400c12d8b596ae4c227058015c56aa974286de16a43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjor.1100150324$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjor.1100150324$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9246098$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mills, Barbara G.</creatorcontrib><creatorcontrib>Oizumi, Jun</creatorcontrib><creatorcontrib>Kudo, Emily</creatorcontrib><creatorcontrib>Rude, Robert</creatorcontrib><title>Robertsonian translocations in Paget's disease of bone</title><title>Journal of orthopaedic research</title><addtitle>J. Orthop. Res</addtitle><description>The karyotypes of 14 patients with Paget's disease of bone were studied. The patients were recruited from our bone metabolism clinic where they received specific therapy for their skeletal disease. Eight of the 14 patients had chromosomal translocations localized to the D and G groups. None of the patients were related to one another, nor had any had the same lifelong environment. Thus, 57% of a sample of active patients with Paget's disease had Robertsonian translocations. By comparison, an age and sex‐matched group of eight controls and 13 patients with osteoporosis who had been treated with bisphosphonates demonstrated no Robertsonian translocations. The prevalence of Robertsonian translocations in 14,000 newborns was reported to be 0.1%. These data suggest that a factor from the environment introduced during the lifetime of the patient could be present and could, in addition to genetic factors, affect gene replication during the development of Paget's disease.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Chromosomes, Human, Pair 13</subject><subject>Chromosomes, Human, Pair 14</subject><subject>Chromosomes, Human, Pair 15</subject><subject>Diseases</subject><subject>Female</subject><subject>Genes</subject><subject>Humans</subject><subject>Karyotyping</subject><subject>Male</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>Osteitis Deformans - genetics</subject><subject>Phenotype</subject><subject>Translocation, Genetic</subject><issn>0736-0266</issn><issn>1554-527X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkM1PwkAQxTdGg4hevZk0HvRUnP1ujwYVJQiGaDReNttlMcXSxd0S5b-3BILRi3OZSeb3XvIeQscY2hiAXEydb-P6whwoYTuoiTlnMSfyZRc1QVIRAxFiHx2EMAUAiUnSQI2UMAFp0kRi5DLrq-DKXJdR5XUZCmd0lbsyRHkZPeg3W52HaJwHq4ON3CTKXGkP0d5EF8EebXYLPd1cP3Zu4_6we9e57MeGppjFIgPIaCK50VnCcD0mSykDMJiMk4ynQltmCJHAkzqB4ULrVDKSiLHFQjPaQmdr37l3HwsbKjXLg7FFoUvrFkHJFEsiRfIvSDAFAkzW4OkfcOoWvqxDKEI5ZpjyFdReQ8a7ELydqLnPZ9ovFQa1qr0WefVTey042bguspkdb_FNz_U_Xf8_88Iu_3FTveHol3e81uahsl9brfbvSkgquXoedNXgtXtF77lUPfoNmp-aSg</recordid><startdate>199705</startdate><enddate>199705</enddate><creator>Mills, Barbara G.</creator><creator>Oizumi, Jun</creator><creator>Kudo, Emily</creator><creator>Rude, Robert</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>199705</creationdate><title>Robertsonian translocations in Paget's disease of bone</title><author>Mills, Barbara G. ; Oizumi, Jun ; Kudo, Emily ; Rude, Robert</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3914-6b00b3875cab841111cb93400c12d8b596ae4c227058015c56aa974286de16a43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Chromosomes, Human, Pair 13</topic><topic>Chromosomes, Human, Pair 14</topic><topic>Chromosomes, Human, Pair 15</topic><topic>Diseases</topic><topic>Female</topic><topic>Genes</topic><topic>Humans</topic><topic>Karyotyping</topic><topic>Male</topic><topic>Metabolism</topic><topic>Middle Aged</topic><topic>Osteitis Deformans - genetics</topic><topic>Phenotype</topic><topic>Translocation, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mills, Barbara G.</creatorcontrib><creatorcontrib>Oizumi, Jun</creatorcontrib><creatorcontrib>Kudo, Emily</creatorcontrib><creatorcontrib>Rude, Robert</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of orthopaedic research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mills, Barbara G.</au><au>Oizumi, Jun</au><au>Kudo, Emily</au><au>Rude, Robert</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Robertsonian translocations in Paget's disease of bone</atitle><jtitle>Journal of orthopaedic research</jtitle><addtitle>J. Orthop. Res</addtitle><date>1997-05</date><risdate>1997</risdate><volume>15</volume><issue>3</issue><spage>477</spage><epage>481</epage><pages>477-481</pages><issn>0736-0266</issn><eissn>1554-527X</eissn><coden>JOREDR</coden><abstract>The karyotypes of 14 patients with Paget's disease of bone were studied. The patients were recruited from our bone metabolism clinic where they received specific therapy for their skeletal disease. Eight of the 14 patients had chromosomal translocations localized to the D and G groups. None of the patients were related to one another, nor had any had the same lifelong environment. Thus, 57% of a sample of active patients with Paget's disease had Robertsonian translocations. By comparison, an age and sex‐matched group of eight controls and 13 patients with osteoporosis who had been treated with bisphosphonates demonstrated no Robertsonian translocations. The prevalence of Robertsonian translocations in 14,000 newborns was reported to be 0.1%. 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| subjects | Aged Aged, 80 and over Chromosomes, Human, Pair 13 Chromosomes, Human, Pair 14 Chromosomes, Human, Pair 15 Diseases Female Genes Humans Karyotyping Male Metabolism Middle Aged Osteitis Deformans - genetics Phenotype Translocation, Genetic |
| title | Robertsonian translocations in Paget's disease of bone |
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