Depression in patients with cirrhosis : Impact on outcome
The impact of depression (assessed by the Beck Depression Inventory) on quality of life and outcome was prospectively assessed in adult patients with cirrhosis. Patients with depression had significantly poorer perceived quality of life (P = 0.006), poorer adaptive coping (P = 0.001), and lower func...
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| Veröffentlicht in: | Digestive diseases and sciences 1997-07, Vol.42 (7), p.1421-1427 |
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| container_title | Digestive diseases and sciences |
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| creator | SINGH, N GAYOWSKI, T WAGENER, M. M MARINO, I. R |
| description | The impact of depression (assessed by the Beck Depression Inventory) on quality of life and outcome was prospectively assessed in adult patients with cirrhosis. Patients with depression had significantly poorer perceived quality of life (P = 0.006), poorer adaptive coping (P = 0.001), and lower functional status, i.e., Karnofsky performance score (P = 0.06), as compared to the nondepressed patients. Survival after transplantation was not different between depressed and nondepressed patients. However, the patients with depression were significantly more likely to die while awaiting transplantation than the nondepressed patients (P = 0.02). The difference in mortality between the depressed and the nondepressed patients with end-stage liver disease could not be explained by the severity of illness variables; Child-Pugh score, complications of liver disease, renal function, serum albumin, prothrombin time, frequency and duration of hospitalizations were not significantly different for depressed and nondepressed patients. Symptoms of depression should be sought in patients with cirrhosis since depression is a modifiable illness that is amenable to treatment. |
| doi_str_mv | 10.1023/A:1018898106656 |
| format | Article |
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The difference in mortality between the depressed and the nondepressed patients with end-stage liver disease could not be explained by the severity of illness variables; Child-Pugh score, complications of liver disease, renal function, serum albumin, prothrombin time, frequency and duration of hospitalizations were not significantly different for depressed and nondepressed patients. Symptoms of depression should be sought in patients with cirrhosis since depression is a modifiable illness that is amenable to treatment.</description><identifier>ISSN: 0163-2116</identifier><identifier>EISSN: 1573-2568</identifier><identifier>DOI: 10.1023/A:1018898106656</identifier><identifier>PMID: 9246040</identifier><identifier>CODEN: DDSCDJ</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Biological and medical sciences ; Depression - diagnosis ; Depression - epidemiology ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Incidence ; Liver Cirrhosis - mortality ; Liver Cirrhosis - psychology ; Liver Cirrhosis - surgery ; Liver Transplantation - mortality ; Liver Transplantation - psychology ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Medical sciences ; Middle Aged ; Other diseases. 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M</creatorcontrib><creatorcontrib>MARINO, I. R</creatorcontrib><title>Depression in patients with cirrhosis : Impact on outcome</title><title>Digestive diseases and sciences</title><addtitle>Dig Dis Sci</addtitle><description>The impact of depression (assessed by the Beck Depression Inventory) on quality of life and outcome was prospectively assessed in adult patients with cirrhosis. Patients with depression had significantly poorer perceived quality of life (P = 0.006), poorer adaptive coping (P = 0.001), and lower functional status, i.e., Karnofsky performance score (P = 0.06), as compared to the nondepressed patients. Survival after transplantation was not different between depressed and nondepressed patients. However, the patients with depression were significantly more likely to die while awaiting transplantation than the nondepressed patients (P = 0.02). The difference in mortality between the depressed and the nondepressed patients with end-stage liver disease could not be explained by the severity of illness variables; Child-Pugh score, complications of liver disease, renal function, serum albumin, prothrombin time, frequency and duration of hospitalizations were not significantly different for depressed and nondepressed patients. Symptoms of depression should be sought in patients with cirrhosis since depression is a modifiable illness that is amenable to treatment.</description><subject>Biological and medical sciences</subject><subject>Depression - diagnosis</subject><subject>Depression - epidemiology</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Incidence</subject><subject>Liver Cirrhosis - mortality</subject><subject>Liver Cirrhosis - psychology</subject><subject>Liver Cirrhosis - surgery</subject><subject>Liver Transplantation - mortality</subject><subject>Liver Transplantation - psychology</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Other diseases. 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M</au><au>MARINO, I. R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Depression in patients with cirrhosis : Impact on outcome</atitle><jtitle>Digestive diseases and sciences</jtitle><addtitle>Dig Dis Sci</addtitle><date>1997-07-01</date><risdate>1997</risdate><volume>42</volume><issue>7</issue><spage>1421</spage><epage>1427</epage><pages>1421-1427</pages><issn>0163-2116</issn><eissn>1573-2568</eissn><coden>DDSCDJ</coden><abstract>The impact of depression (assessed by the Beck Depression Inventory) on quality of life and outcome was prospectively assessed in adult patients with cirrhosis. Patients with depression had significantly poorer perceived quality of life (P = 0.006), poorer adaptive coping (P = 0.001), and lower functional status, i.e., Karnofsky performance score (P = 0.06), as compared to the nondepressed patients. Survival after transplantation was not different between depressed and nondepressed patients. However, the patients with depression were significantly more likely to die while awaiting transplantation than the nondepressed patients (P = 0.02). The difference in mortality between the depressed and the nondepressed patients with end-stage liver disease could not be explained by the severity of illness variables; Child-Pugh score, complications of liver disease, renal function, serum albumin, prothrombin time, frequency and duration of hospitalizations were not significantly different for depressed and nondepressed patients. Symptoms of depression should be sought in patients with cirrhosis since depression is a modifiable illness that is amenable to treatment.</abstract><cop>Heidelberg</cop><pub>Springer</pub><pmid>9246040</pmid><doi>10.1023/A:1018898106656</doi><tpages>7</tpages></addata></record> |
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| subjects | Biological and medical sciences Depression - diagnosis Depression - epidemiology Female Gastroenterology. Liver. Pancreas. Abdomen Humans Incidence Liver Cirrhosis - mortality Liver Cirrhosis - psychology Liver Cirrhosis - surgery Liver Transplantation - mortality Liver Transplantation - psychology Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Middle Aged Other diseases. Semiology Prospective Studies Quality of Life Survival Rate Treatment Outcome |
| title | Depression in patients with cirrhosis : Impact on outcome |
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