Long-term potentiation of evoked and spontaneous neuronal activity in the grafted hippocampus
Adult rats with unilateral fimbria-fornix lesion received fetal hippocampal grafts into the lesion cavity. Seven to ten months after the transplantation the graft was examined for long-term potentiation (LTP) in response to host hippocampus and direct graft stimulation. High frequency tetanizing tra...
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| Veröffentlicht in: | Experimental brain research 1989-01, Vol.76 (2), p.401-408 |
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| creator | BUZSAKI, G WIESNER, J HENRIKSEN, S. J GAGE, F. H |
| description | Adult rats with unilateral fimbria-fornix lesion received fetal hippocampal grafts into the lesion cavity. Seven to ten months after the transplantation the graft was examined for long-term potentiation (LTP) in response to host hippocampus and direct graft stimulation. High frequency tetanizing trains delivered to either the host hippocampus or the graft resulted in augmented field potentials and prolonged neuronal discharges in the graft lasting several hours. Very low currents (10-30 microA) were required to induce LTP by direct graft stimulation. In addition to the enhancement of evoked responses, the frequency of occurrence of spontaneously occurring EEG spikes and concurrent population neuronal bursts in the graft increased significantly after the tetanizing trains. These findings suggest that the physiological-biochemical mechanisms required for plastic changes of synaptic efficacy are present in the grafted hippocampus. |
| doi_str_mv | 10.1007/BF00247897 |
| format | Article |
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J ; GAGE, F. H</creator><creatorcontrib>BUZSAKI, G ; WIESNER, J ; HENRIKSEN, S. J ; GAGE, F. H</creatorcontrib><description>Adult rats with unilateral fimbria-fornix lesion received fetal hippocampal grafts into the lesion cavity. Seven to ten months after the transplantation the graft was examined for long-term potentiation (LTP) in response to host hippocampus and direct graft stimulation. High frequency tetanizing trains delivered to either the host hippocampus or the graft resulted in augmented field potentials and prolonged neuronal discharges in the graft lasting several hours. Very low currents (10-30 microA) were required to induce LTP by direct graft stimulation. In addition to the enhancement of evoked responses, the frequency of occurrence of spontaneously occurring EEG spikes and concurrent population neuronal bursts in the graft increased significantly after the tetanizing trains. These findings suggest that the physiological-biochemical mechanisms required for plastic changes of synaptic efficacy are present in the grafted hippocampus.</description><identifier>ISSN: 0014-4819</identifier><identifier>EISSN: 1432-1106</identifier><identifier>DOI: 10.1007/BF00247897</identifier><identifier>PMID: 2767191</identifier><identifier>CODEN: EXBRAP</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Action Potentials ; Adaptation, Physiological ; Animals ; Biological and medical sciences ; Central nervous system ; Electric Stimulation ; Electrophysiology ; Female ; Fundamental and applied biological sciences. 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J</creatorcontrib><creatorcontrib>GAGE, F. H</creatorcontrib><title>Long-term potentiation of evoked and spontaneous neuronal activity in the grafted hippocampus</title><title>Experimental brain research</title><addtitle>Exp Brain Res</addtitle><description>Adult rats with unilateral fimbria-fornix lesion received fetal hippocampal grafts into the lesion cavity. Seven to ten months after the transplantation the graft was examined for long-term potentiation (LTP) in response to host hippocampus and direct graft stimulation. High frequency tetanizing trains delivered to either the host hippocampus or the graft resulted in augmented field potentials and prolonged neuronal discharges in the graft lasting several hours. Very low currents (10-30 microA) were required to induce LTP by direct graft stimulation. In addition to the enhancement of evoked responses, the frequency of occurrence of spontaneously occurring EEG spikes and concurrent population neuronal bursts in the graft increased significantly after the tetanizing trains. These findings suggest that the physiological-biochemical mechanisms required for plastic changes of synaptic efficacy are present in the grafted hippocampus.</description><subject>Action Potentials</subject><subject>Adaptation, Physiological</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Central nervous system</subject><subject>Electric Stimulation</subject><subject>Electrophysiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Graft Survival</subject><subject>Hippocampus - physiology</subject><subject>Hippocampus - transplantation</subject><subject>Neuronal Plasticity</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0014-4819</issn><issn>1432-1106</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkL1P5DAQxS0EWhaO5nokN1CcFM5jO3ZcAjo-pJVojvIUzSYO-EjsYDtI_PdktSsoqWZG7zdPM4-Qn8AugDH9--qGMS51ZfQeWYIUvABgap8sGQNZyArMITlK6f9mFJotyIJrpcHAkvxbBf9UZBsHOoZsfXaYXfA0dNS-hRfbUvQtTWPwGb0NU6LeTjF47Ck22b25_E6dp_nZ0qeIXZ4Xnt04hgaHcUo_yEGHfbInu3pMHm_-_L2-K1YPt_fXl6uiEVLkwrZlBWxdmq6zrVGqAm1UJdtqLZGhEVwo3iJnuoS11mXFFWCFYv5LWRBzd0zOt75jDK-TTbkeXGps329vrrUBzUstvgWhlKxUQs3gry3YxJBStF09RjdgfK-B1ZvQ66_QZ_h05zqtB9t-oruUZ_1sp2NqsO8i-salL0dTcsmAiQ_JEIiG</recordid><startdate>19890101</startdate><enddate>19890101</enddate><creator>BUZSAKI, G</creator><creator>WIESNER, J</creator><creator>HENRIKSEN, S. 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H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c343t-ed5810b59ffed9668179684d8b4a0a932362da20751b7758261a8a38196e138a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Action Potentials</topic><topic>Adaptation, Physiological</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Central nervous system</topic><topic>Electric Stimulation</topic><topic>Electrophysiology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Graft Survival</topic><topic>Hippocampus - physiology</topic><topic>Hippocampus - transplantation</topic><topic>Neuronal Plasticity</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BUZSAKI, G</creatorcontrib><creatorcontrib>WIESNER, J</creatorcontrib><creatorcontrib>HENRIKSEN, S. J</creatorcontrib><creatorcontrib>GAGE, F. H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BUZSAKI, G</au><au>WIESNER, J</au><au>HENRIKSEN, S. J</au><au>GAGE, F. H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long-term potentiation of evoked and spontaneous neuronal activity in the grafted hippocampus</atitle><jtitle>Experimental brain research</jtitle><addtitle>Exp Brain Res</addtitle><date>1989-01-01</date><risdate>1989</risdate><volume>76</volume><issue>2</issue><spage>401</spage><epage>408</epage><pages>401-408</pages><issn>0014-4819</issn><eissn>1432-1106</eissn><coden>EXBRAP</coden><abstract>Adult rats with unilateral fimbria-fornix lesion received fetal hippocampal grafts into the lesion cavity. Seven to ten months after the transplantation the graft was examined for long-term potentiation (LTP) in response to host hippocampus and direct graft stimulation. High frequency tetanizing trains delivered to either the host hippocampus or the graft resulted in augmented field potentials and prolonged neuronal discharges in the graft lasting several hours. Very low currents (10-30 microA) were required to induce LTP by direct graft stimulation. In addition to the enhancement of evoked responses, the frequency of occurrence of spontaneously occurring EEG spikes and concurrent population neuronal bursts in the graft increased significantly after the tetanizing trains. These findings suggest that the physiological-biochemical mechanisms required for plastic changes of synaptic efficacy are present in the grafted hippocampus.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>2767191</pmid><doi>10.1007/BF00247897</doi><tpages>8</tpages></addata></record> |
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| ispartof | Experimental brain research, 1989-01, Vol.76 (2), p.401-408 |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Action Potentials Adaptation, Physiological Animals Biological and medical sciences Central nervous system Electric Stimulation Electrophysiology Female Fundamental and applied biological sciences. Psychology Graft Survival Hippocampus - physiology Hippocampus - transplantation Neuronal Plasticity Rats Rats, Inbred Strains Vertebrates: nervous system and sense organs |
| title | Long-term potentiation of evoked and spontaneous neuronal activity in the grafted hippocampus |
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