Relationship of dehydroepiandrosterone and cortisol in disease
Does dehydroepiandrosterone act as an adrenal hormone in humans to maintain cortisol homeostasis by serving as a cortisol antagonist? If so, dehydroepiandrosterone might block the development of the diverse pathological processes potentiated by prolonged cortisol hyperactivity. And the plasma concen...
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| Veröffentlicht in: | Medical hypotheses 1997-07, Vol.49 (1), p.85-91 |
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| container_title | Medical hypotheses |
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| creator | Hechter, O. Grossman, A. Chatterton, R.T. |
| description | Does dehydroepiandrosterone act as an adrenal hormone in humans to maintain cortisol homeostasis by serving as a cortisol antagonist? If so, dehydroepiandrosterone might block the development of the diverse pathological processes potentiated by prolonged cortisol hyperactivity. And the plasma concentrations of total dehydroepiandrosterone and total cortisol, expressed as a
C/D ratio, would have an important influence on the development of age-related pathology in diseases exacerbated by cortisol hyperactivity. Several major age-related diseases, designated as cortisol-potentiated diseases, belong in this category.
The
C/D concept predicts, other factors being equal, that the risk of initiation and progression of these diseases at all ages is directly related to the
C/D ratio, individuals with elevated
C/D ratios being at high risk. |
| doi_str_mv | 10.1016/S0306-9877(97)90258-9 |
| format | Article |
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C/D ratio, would have an important influence on the development of age-related pathology in diseases exacerbated by cortisol hyperactivity. Several major age-related diseases, designated as cortisol-potentiated diseases, belong in this category.
The
C/D concept predicts, other factors being equal, that the risk of initiation and progression of these diseases at all ages is directly related to the
C/D ratio, individuals with elevated
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C/D ratio, would have an important influence on the development of age-related pathology in diseases exacerbated by cortisol hyperactivity. Several major age-related diseases, designated as cortisol-potentiated diseases, belong in this category.
The
C/D concept predicts, other factors being equal, that the risk of initiation and progression of these diseases at all ages is directly related to the
C/D ratio, individuals with elevated
C/D ratios being at high risk.</description><subject>Adrenal Cortex Hormones - physiology</subject><subject>Adrenals. Adrenal axis. Renin-angiotensin system (diseases)</subject><subject>Aging - physiology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Circadian Rhythm</subject><subject>Cushing Syndrome - etiology</subject><subject>Cushing Syndrome - physiopathology</subject><subject>Dehydroepiandrosterone - physiology</subject><subject>Endocrinopathies</subject><subject>Glucocorticoids - adverse effects</subject><subject>Glucocorticoids - antagonists & inhibitors</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Hydrocortisone - physiology</subject><subject>Medical sciences</subject><subject>Models, Biological</subject><subject>Non tumoral diseases. Target tissue resistance. Benign neoplasms</subject><subject>Stress, Physiological - physiopathology</subject><subject>T-Lymphocytes - immunology</subject><subject>T-Lymphocytes - physiology</subject><issn>0306-9877</issn><issn>1532-2777</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1rGzEQhkVocZyPn2DYQyjtYZuRVlqtLgnBNE3AUEjas5ClEVZYrxxpXfC_rxwbXwuCQcwzmlcPITMK3ynQ9vYVGmhr1Un5VclvCpjoanVGplQ0rGZSyk9kekLOyUXObwCgeNNNyEQxLhXlU3L3gr0ZQxzyKmyq6CuHq51LETfBDKXmEVMcsCqXysY0hhz7KgyVCxlNxivy2Zs-4_WxXpI_jz9-z5_qxa-fz_OHRW25EGNtmUex7HxLRSvBL50ETiXn4KwD6LygrWiMY5J1rmNLiUp5ZxuFSrYKQTSX5Mvh3U2K71vMo16HbLHvzYBxm3X5jARKeQHFAbQle07o9SaFtUk7TUHvvekPb3ovRaty9t60KnOz44Ltco3uNHUUVfo3x77J1vQ-mcGGfMKY5AzEPuf9AcMi42_ApLMNOFh0IaEdtYvhP0H-AWDVibg</recordid><startdate>19970701</startdate><enddate>19970701</enddate><creator>Hechter, O.</creator><creator>Grossman, A.</creator><creator>Chatterton, R.T.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19970701</creationdate><title>Relationship of dehydroepiandrosterone and cortisol in disease</title><author>Hechter, O. ; Grossman, A. ; Chatterton, R.T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-c2fe5b8f615670fbd70417440dcd008f51653ad2728d82b7e99fdc39e9769e053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adrenal Cortex Hormones - physiology</topic><topic>Adrenals. Adrenal axis. Renin-angiotensin system (diseases)</topic><topic>Aging - physiology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Circadian Rhythm</topic><topic>Cushing Syndrome - etiology</topic><topic>Cushing Syndrome - physiopathology</topic><topic>Dehydroepiandrosterone - physiology</topic><topic>Endocrinopathies</topic><topic>Glucocorticoids - adverse effects</topic><topic>Glucocorticoids - antagonists & inhibitors</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>Hydrocortisone - physiology</topic><topic>Medical sciences</topic><topic>Models, Biological</topic><topic>Non tumoral diseases. Target tissue resistance. Benign neoplasms</topic><topic>Stress, Physiological - physiopathology</topic><topic>T-Lymphocytes - immunology</topic><topic>T-Lymphocytes - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hechter, O.</creatorcontrib><creatorcontrib>Grossman, A.</creatorcontrib><creatorcontrib>Chatterton, R.T.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Medical hypotheses</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hechter, O.</au><au>Grossman, A.</au><au>Chatterton, R.T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship of dehydroepiandrosterone and cortisol in disease</atitle><jtitle>Medical hypotheses</jtitle><addtitle>Med Hypotheses</addtitle><date>1997-07-01</date><risdate>1997</risdate><volume>49</volume><issue>1</issue><spage>85</spage><epage>91</epage><pages>85-91</pages><issn>0306-9877</issn><eissn>1532-2777</eissn><abstract>Does dehydroepiandrosterone act as an adrenal hormone in humans to maintain cortisol homeostasis by serving as a cortisol antagonist? If so, dehydroepiandrosterone might block the development of the diverse pathological processes potentiated by prolonged cortisol hyperactivity. And the plasma concentrations of total dehydroepiandrosterone and total cortisol, expressed as a
C/D ratio, would have an important influence on the development of age-related pathology in diseases exacerbated by cortisol hyperactivity. Several major age-related diseases, designated as cortisol-potentiated diseases, belong in this category.
The
C/D concept predicts, other factors being equal, that the risk of initiation and progression of these diseases at all ages is directly related to the
C/D ratio, individuals with elevated
C/D ratios being at high risk.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>9247914</pmid><doi>10.1016/S0306-9877(97)90258-9</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0306-9877 |
| ispartof | Medical hypotheses, 1997-07, Vol.49 (1), p.85-91 |
| issn | 0306-9877 1532-2777 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adrenal Cortex Hormones - physiology Adrenals. Adrenal axis. Renin-angiotensin system (diseases) Aging - physiology Animals Biological and medical sciences Circadian Rhythm Cushing Syndrome - etiology Cushing Syndrome - physiopathology Dehydroepiandrosterone - physiology Endocrinopathies Glucocorticoids - adverse effects Glucocorticoids - antagonists & inhibitors Homeostasis Humans Hydrocortisone - physiology Medical sciences Models, Biological Non tumoral diseases. Target tissue resistance. Benign neoplasms Stress, Physiological - physiopathology T-Lymphocytes - immunology T-Lymphocytes - physiology |
| title | Relationship of dehydroepiandrosterone and cortisol in disease |
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