The gene for the human putative apoE receptor is on chromosome 12 in the segment q13–14
We have previously described the cDNA coding for a new lipoprotein receptor that contains domains closely related to the ligand-binding domain of the LDL receptor. We have now investigated the localization of the gene for this new receptor by hybridization of the cDNA to panels of rodent cells conta...
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| Veröffentlicht in: | Genomics (San Diego, Calif.) Calif.), 1989-07, Vol.5 (1), p.65-69 |
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| container_end_page | 69 |
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| container_issue | 1 |
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| container_title | Genomics (San Diego, Calif.) |
| container_volume | 5 |
| creator | Myklebost, Ola Arheden, Kristina Rogne, Sissel Kessel, Ad Geurts van Mandahl, Nils Herz, Joachim Stanley, Keith Heim, Sverre Mitelman, Felix |
| description | We have previously described the cDNA coding for a new lipoprotein receptor that contains domains closely related to the ligand-binding domain of the LDL receptor. We have now investigated the localization of the gene for this new receptor by hybridization of the cDNA to panels of rodent cells containing subsets of human chromosomes and by
in situ hybridization of the cDNA to chromosomes. The gene maps to 12q13–14, a known hot spot for chromosomal rearrangements in human neoplasia. Of particular interest is the frequent involvement of the 12q13–14 segment in clonal abnormalities in lipomas and myxoid liposarcomas, and it is possible that LRP may play a role in the pathogenesis of such tumors. |
| doi_str_mv | 10.1016/0888-7543(89)90087-6 |
| format | Article |
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in situ hybridization of the cDNA to chromosomes. The gene maps to 12q13–14, a known hot spot for chromosomal rearrangements in human neoplasia. Of particular interest is the frequent involvement of the 12q13–14 segment in clonal abnormalities in lipomas and myxoid liposarcomas, and it is possible that LRP may play a role in the pathogenesis of such tumors.</description><subject>Animals</subject><subject>Autoradiography</subject><subject>Chromosome Aberrations</subject><subject>Chromosome Banding</subject><subject>Chromosome Mapping - methods</subject><subject>Chromosomes, Human, Pair 12</subject><subject>Cricetinae</subject><subject>DNA - genetics</subject><subject>DNA Probes</subject><subject>Humans</subject><subject>Hybrid Cells</subject><subject>Low Density Lipoprotein Receptor-Related Protein-1</subject><subject>Metaphase</subject><subject>Nucleic Acid Hybridization</subject><subject>Receptors, Cell Surface - genetics</subject><issn>0888-7543</issn><issn>1089-8646</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1q3DAQx0VJSTZp3yABnUJzcKuxbHl0CYQlH4VAL9tDT0KrHWcV1pZXshd66zvkDfsk9X6wx_Q0DPP7zww_xi5BfAUB6ptAxKwqC_kF9Y0WAqtMfWATEKgzVIU6YZMjcsbOU3oVQmiJ-Sk7zcsCdSkm7NdsSfyFWuJ1iLwfm-XQ2JZ3Q297vyFuu3DPIznq-hHwiYeWu2UMTUihIQ459-0ul-ilobbna5B__7xB8Yl9rO0q0edDvWA_H-5n06fs-cfj9-ndc-YkYp_ZeT4-6EDZWte1JdAlEqBDtXACEEsCWeQql1I6PZdCWQvOauXqCiDPUV6w6_3eLob1QKk3jU-OVivbUhiSqTQoDbL8LwhlhUKLagSLPehiSClSbbroGxt_GxBmq95svZqtV4Pa7NQbNcauDvuHeUOLY-jgepzf7uc02th4iiY5T62jhR_99mYR_PsH_gE8LpGz</recordid><startdate>19890701</startdate><enddate>19890701</enddate><creator>Myklebost, Ola</creator><creator>Arheden, Kristina</creator><creator>Rogne, Sissel</creator><creator>Kessel, Ad Geurts van</creator><creator>Mandahl, Nils</creator><creator>Herz, Joachim</creator><creator>Stanley, Keith</creator><creator>Heim, Sverre</creator><creator>Mitelman, Felix</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19890701</creationdate><title>The gene for the human putative apoE receptor is on chromosome 12 in the segment q13–14</title><author>Myklebost, Ola ; Arheden, Kristina ; Rogne, Sissel ; Kessel, Ad Geurts van ; Mandahl, Nils ; Herz, Joachim ; Stanley, Keith ; Heim, Sverre ; Mitelman, Felix</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-ab2754c16af9ffae1958e18c86dc01885e134262333c9b306aa1ca96cf7112283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Animals</topic><topic>Autoradiography</topic><topic>Chromosome Aberrations</topic><topic>Chromosome Banding</topic><topic>Chromosome Mapping - methods</topic><topic>Chromosomes, Human, Pair 12</topic><topic>Cricetinae</topic><topic>DNA - genetics</topic><topic>DNA Probes</topic><topic>Humans</topic><topic>Hybrid Cells</topic><topic>Low Density Lipoprotein Receptor-Related Protein-1</topic><topic>Metaphase</topic><topic>Nucleic Acid Hybridization</topic><topic>Receptors, Cell Surface - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Myklebost, Ola</creatorcontrib><creatorcontrib>Arheden, Kristina</creatorcontrib><creatorcontrib>Rogne, Sissel</creatorcontrib><creatorcontrib>Kessel, Ad Geurts van</creatorcontrib><creatorcontrib>Mandahl, Nils</creatorcontrib><creatorcontrib>Herz, Joachim</creatorcontrib><creatorcontrib>Stanley, Keith</creatorcontrib><creatorcontrib>Heim, Sverre</creatorcontrib><creatorcontrib>Mitelman, Felix</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Genomics (San Diego, Calif.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Myklebost, Ola</au><au>Arheden, Kristina</au><au>Rogne, Sissel</au><au>Kessel, Ad Geurts van</au><au>Mandahl, Nils</au><au>Herz, Joachim</au><au>Stanley, Keith</au><au>Heim, Sverre</au><au>Mitelman, Felix</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The gene for the human putative apoE receptor is on chromosome 12 in the segment q13–14</atitle><jtitle>Genomics (San Diego, Calif.)</jtitle><addtitle>Genomics</addtitle><date>1989-07-01</date><risdate>1989</risdate><volume>5</volume><issue>1</issue><spage>65</spage><epage>69</epage><pages>65-69</pages><issn>0888-7543</issn><eissn>1089-8646</eissn><abstract>We have previously described the cDNA coding for a new lipoprotein receptor that contains domains closely related to the ligand-binding domain of the LDL receptor. 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in situ hybridization of the cDNA to chromosomes. The gene maps to 12q13–14, a known hot spot for chromosomal rearrangements in human neoplasia. Of particular interest is the frequent involvement of the 12q13–14 segment in clonal abnormalities in lipomas and myxoid liposarcomas, and it is possible that LRP may play a role in the pathogenesis of such tumors.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>2548950</pmid><doi>10.1016/0888-7543(89)90087-6</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0888-7543 |
| ispartof | Genomics (San Diego, Calif.), 1989-07, Vol.5 (1), p.65-69 |
| issn | 0888-7543 1089-8646 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79169135 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Autoradiography Chromosome Aberrations Chromosome Banding Chromosome Mapping - methods Chromosomes, Human, Pair 12 Cricetinae DNA - genetics DNA Probes Humans Hybrid Cells Low Density Lipoprotein Receptor-Related Protein-1 Metaphase Nucleic Acid Hybridization Receptors, Cell Surface - genetics |
| title | The gene for the human putative apoE receptor is on chromosome 12 in the segment q13–14 |
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