Anti-α chain monoclonal antibodies of equine MHC class-II antigens: applications to equine infectious anaemia
This paper describes the characteristics of a monoclonal antibody (mAb), 6B I1 C3, that recognises most equine monocytic cells, as well as B- and T-lymphocytes. The T CD4+ and T CD8+ of this latter population are also stained by the 6B 11 C3 mAb. On the basis of the distribution of membrane antigens...
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| Veröffentlicht in: | Research in veterinary science 1997-03, Vol.62 (2), p.99-104 |
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| creator | Bendali-Ahcéne, S Cadore, J.L Fontaine, M Monier, J.C |
| description | This paper describes the characteristics of a monoclonal antibody (mAb), 6B I1 C3, that recognises most equine monocytic cells, as well as B- and T-lymphocytes. The T CD4+ and T CD8+ of this latter population are also stained by the 6B 11 C3 mAb. On the basis of the distribution of membrane antigens on these cell populations, and of immunohistochemistry results, this mAb appears to be an anti-equine class-II major histocompatibility complex (
mhc) antigen. In horses, the hyperexpression of the MHC class-II antigen on T cells is an indication of activated lymphocytes. A decrease in the percentage of lymphocytes stained by 6B 11 C3 was observed in horses with persistent equine infectious anaemia. |
| doi_str_mv | 10.1016/S0034-5288(97)90128-4 |
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mhc) antigen. In horses, the hyperexpression of the MHC class-II antigen on T cells is an indication of activated lymphocytes. A decrease in the percentage of lymphocytes stained by 6B 11 C3 was observed in horses with persistent equine infectious anaemia.</description><identifier>ISSN: 0034-5288</identifier><identifier>EISSN: 1532-2661</identifier><identifier>DOI: 10.1016/S0034-5288(97)90128-4</identifier><identifier>PMID: 9243705</identifier><language>eng</language><publisher>England: Elsevier India Pvt Ltd</publisher><subject>Animals ; Antibodies, Monoclonal - analysis ; Antibodies, Monoclonal - immunology ; Blotting, Western - veterinary ; CD4 Antigens - analysis ; CD4 Antigens - immunology ; CD8 Antigens - analysis ; CD8 Antigens - immunology ; Cross Reactions ; Electrophoresis, Polyacrylamide Gel - veterinary ; Equine Infectious Anemia - blood ; Equine Infectious Anemia - immunology ; Flow Cytometry - veterinary ; Fluorescent Antibody Technique - veterinary ; Histocompatibility Antigens Class II - analysis ; Histocompatibility Antigens Class II - chemistry ; Histocompatibility Antigens Class II - immunology ; Horse Diseases - blood ; Horse Diseases - immunology ; Horses ; Immunohistochemistry ; Leukocytes - immunology ; Lymph Nodes - cytology ; Lymph Nodes - immunology ; Lymphocyte Activation - physiology ; Mice ; Mice, Inbred BALB C ; Molecular Weight ; Phenotype ; Thymus Gland - immunology</subject><ispartof>Research in veterinary science, 1997-03, Vol.62 (2), p.99-104</ispartof><rights>1997</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c360t-f722b83dc5e583589f5acb3a106590bc6f1a267acab9923e9a5e1c5e73deffac3</citedby><cites>FETCH-LOGICAL-c360t-f722b83dc5e583589f5acb3a106590bc6f1a267acab9923e9a5e1c5e73deffac3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0034528897901284$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9243705$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bendali-Ahcéne, S</creatorcontrib><creatorcontrib>Cadore, J.L</creatorcontrib><creatorcontrib>Fontaine, M</creatorcontrib><creatorcontrib>Monier, J.C</creatorcontrib><title>Anti-α chain monoclonal antibodies of equine MHC class-II antigens: applications to equine infectious anaemia</title><title>Research in veterinary science</title><addtitle>Res Vet Sci</addtitle><description>This paper describes the characteristics of a monoclonal antibody (mAb), 6B I1 C3, that recognises most equine monocytic cells, as well as B- and T-lymphocytes. The T CD4+ and T CD8+ of this latter population are also stained by the 6B 11 C3 mAb. On the basis of the distribution of membrane antigens on these cell populations, and of immunohistochemistry results, this mAb appears to be an anti-equine class-II major histocompatibility complex (
mhc) antigen. In horses, the hyperexpression of the MHC class-II antigen on T cells is an indication of activated lymphocytes. A decrease in the percentage of lymphocytes stained by 6B 11 C3 was observed in horses with persistent equine infectious anaemia.</description><subject>Animals</subject><subject>Antibodies, Monoclonal - analysis</subject><subject>Antibodies, Monoclonal - immunology</subject><subject>Blotting, Western - veterinary</subject><subject>CD4 Antigens - analysis</subject><subject>CD4 Antigens - immunology</subject><subject>CD8 Antigens - analysis</subject><subject>CD8 Antigens - immunology</subject><subject>Cross Reactions</subject><subject>Electrophoresis, Polyacrylamide Gel - veterinary</subject><subject>Equine Infectious Anemia - blood</subject><subject>Equine Infectious Anemia - immunology</subject><subject>Flow Cytometry - veterinary</subject><subject>Fluorescent Antibody Technique - veterinary</subject><subject>Histocompatibility Antigens Class II - analysis</subject><subject>Histocompatibility Antigens Class II - chemistry</subject><subject>Histocompatibility Antigens Class II - immunology</subject><subject>Horse Diseases - blood</subject><subject>Horse Diseases - immunology</subject><subject>Horses</subject><subject>Immunohistochemistry</subject><subject>Leukocytes - immunology</subject><subject>Lymph Nodes - cytology</subject><subject>Lymph Nodes - immunology</subject><subject>Lymphocyte Activation - physiology</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Molecular Weight</subject><subject>Phenotype</subject><subject>Thymus Gland - immunology</subject><issn>0034-5288</issn><issn>1532-2661</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtO3DAUhq2KCgbaRxjJKwSLgC9xEndToRGUkai6aLu2TpzjYpTYM3GmEo_VF-GZ8Fxg29WR_H_n4o-QOWdXnPHq-idjsiyUaJoLXV9qxkVTlB_IjCspClFV_IjM3pETcprSE2Os5Lw-JsdalLJmakbCTZh88fKP2kfwgQ4xRNvHAD2FHLSx85hodBTXGx-Qfr9fUNtDSsVyuSP-YEhfKKxWvbcw-RgSneIb7YNDmx83KbOAg4dP5KODPuHnQz0jv-9ufy3ui4cf35aLm4fCyopNhauFaBvZWYWqkarRToFtJXBWKc1aWzkOoqrBQqu1kKhBIc9wLTt0Dqw8I-f7uasxrjeYJjP4ZLHvIWA-x9SaV41iZQbVHrRjTGlEZ1ajH2B8NpyZrWez82y2Eo2uzc6z2fbNDws27YDde9dBbM6_7nPMv_zrcTTJegwWOz9mJ6aL_j8bXgHBkI9p</recordid><startdate>19970301</startdate><enddate>19970301</enddate><creator>Bendali-Ahcéne, S</creator><creator>Cadore, J.L</creator><creator>Fontaine, M</creator><creator>Monier, J.C</creator><general>Elsevier India Pvt Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19970301</creationdate><title>Anti-α chain monoclonal antibodies of equine MHC class-II antigens: applications to equine infectious anaemia</title><author>Bendali-Ahcéne, S ; Cadore, J.L ; Fontaine, M ; Monier, J.C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c360t-f722b83dc5e583589f5acb3a106590bc6f1a267acab9923e9a5e1c5e73deffac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animals</topic><topic>Antibodies, Monoclonal - analysis</topic><topic>Antibodies, Monoclonal - immunology</topic><topic>Blotting, Western - veterinary</topic><topic>CD4 Antigens - analysis</topic><topic>CD4 Antigens - immunology</topic><topic>CD8 Antigens - analysis</topic><topic>CD8 Antigens - immunology</topic><topic>Cross Reactions</topic><topic>Electrophoresis, Polyacrylamide Gel - veterinary</topic><topic>Equine Infectious Anemia - blood</topic><topic>Equine Infectious Anemia - immunology</topic><topic>Flow Cytometry - veterinary</topic><topic>Fluorescent Antibody Technique - veterinary</topic><topic>Histocompatibility Antigens Class II - analysis</topic><topic>Histocompatibility Antigens Class II - chemistry</topic><topic>Histocompatibility Antigens Class II - immunology</topic><topic>Horse Diseases - blood</topic><topic>Horse Diseases - immunology</topic><topic>Horses</topic><topic>Immunohistochemistry</topic><topic>Leukocytes - immunology</topic><topic>Lymph Nodes - cytology</topic><topic>Lymph Nodes - immunology</topic><topic>Lymphocyte Activation - physiology</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Molecular Weight</topic><topic>Phenotype</topic><topic>Thymus Gland - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bendali-Ahcéne, S</creatorcontrib><creatorcontrib>Cadore, J.L</creatorcontrib><creatorcontrib>Fontaine, M</creatorcontrib><creatorcontrib>Monier, J.C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Research in veterinary science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bendali-Ahcéne, S</au><au>Cadore, J.L</au><au>Fontaine, M</au><au>Monier, J.C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-α chain monoclonal antibodies of equine MHC class-II antigens: applications to equine infectious anaemia</atitle><jtitle>Research in veterinary science</jtitle><addtitle>Res Vet Sci</addtitle><date>1997-03-01</date><risdate>1997</risdate><volume>62</volume><issue>2</issue><spage>99</spage><epage>104</epage><pages>99-104</pages><issn>0034-5288</issn><eissn>1532-2661</eissn><abstract>This paper describes the characteristics of a monoclonal antibody (mAb), 6B I1 C3, that recognises most equine monocytic cells, as well as B- and T-lymphocytes. The T CD4+ and T CD8+ of this latter population are also stained by the 6B 11 C3 mAb. On the basis of the distribution of membrane antigens on these cell populations, and of immunohistochemistry results, this mAb appears to be an anti-equine class-II major histocompatibility complex (
mhc) antigen. In horses, the hyperexpression of the MHC class-II antigen on T cells is an indication of activated lymphocytes. A decrease in the percentage of lymphocytes stained by 6B 11 C3 was observed in horses with persistent equine infectious anaemia.</abstract><cop>England</cop><pub>Elsevier India Pvt Ltd</pub><pmid>9243705</pmid><doi>10.1016/S0034-5288(97)90128-4</doi><tpages>6</tpages></addata></record> |
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| subjects | Animals Antibodies, Monoclonal - analysis Antibodies, Monoclonal - immunology Blotting, Western - veterinary CD4 Antigens - analysis CD4 Antigens - immunology CD8 Antigens - analysis CD8 Antigens - immunology Cross Reactions Electrophoresis, Polyacrylamide Gel - veterinary Equine Infectious Anemia - blood Equine Infectious Anemia - immunology Flow Cytometry - veterinary Fluorescent Antibody Technique - veterinary Histocompatibility Antigens Class II - analysis Histocompatibility Antigens Class II - chemistry Histocompatibility Antigens Class II - immunology Horse Diseases - blood Horse Diseases - immunology Horses Immunohistochemistry Leukocytes - immunology Lymph Nodes - cytology Lymph Nodes - immunology Lymphocyte Activation - physiology Mice Mice, Inbred BALB C Molecular Weight Phenotype Thymus Gland - immunology |
| title | Anti-α chain monoclonal antibodies of equine MHC class-II antigens: applications to equine infectious anaemia |
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