Hormonal Therapy Increases Arterial Compliance in Postmenopausal Women
Objectives. This study investigated the effects of hormonal therapy on large arterial properties. Background. Arterial stiffness is an emerging risk marker for coronary heart disease and is potentially modifiable. Postmenopausal use of hormonal therapy is associated with a lower risk of coronary hea...
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| Veröffentlicht in: | Journal of the American College of Cardiology 1997-08, Vol.30 (2), p.350-356 |
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| creator | Rajkumar, Chakravarthi Kingwell, Bronwyn A. Cameron, James D. Waddell, Tamara Mehra, Rishi Christophidis, Nicholas Komesaroff, Paul A. McGrath, Barry Jennings, Garry L. Sudhir, Krishnankutty Dart, Anthony M. |
| description | Objectives. This study investigated the effects of hormonal therapy on large arterial properties.
Background. Arterial stiffness is an emerging risk marker for coronary heart disease and is potentially modifiable. Postmenopausal use of hormonal therapy is associated with a lower risk of coronary heart disease.
Methods. Total systemic arterial compliance (SAC) and pulse wave velocity (PWV) were determined in 26 premenopausal and 52 postmenopausal women, 26 of whom were taking hormonal therapy.
Results. Arterial compliance was greater in the premenopausal group (mean ± SEM 0.57 ± 0.04 arbitrary compliance units [ACU]) than in the postmenopausal group not taking hormonal therapy (0.26 ± 0.02 ACU, p = 0.001). Postmenopausal women taking hormonal therapy had a significantly increased total SAC compared with women not taking hormonal therapy (0.43 ± 0.02 vs. 0.26 ± 0.02 ACU, p = 0.001). PWV in the aortofemoral region in the premenopausal women was 6.0 ± 0.2 vs. 8.9 ± 0.3 m/s (p < 0.001) in untreated postmenopausal women. However, postmenopausal women taking hormonal therapy had a significantly lower PWV than those not taking hormonal therapy (7.9 ± 0.2 vs. 8.9 ± 0.3 m/s, p = 0.01). Eleven postmenopausal women had their hormone replacement therapy withdrawn for 4 weeks, resulting in a significant decrease in SAC and a significant increase in aortofemoral PWV.
Conclusions. The increased SAC and decreased PWV in women receiving hormonal therapy suggest that such therapy may decrease stiffness of the aorta and large arteries in postmenopausal women, with potential benefit for age-related cardiovascular disorders. The reduction of arterial compliance with age appears to be altered with hormonal therapy. |
| doi_str_mv | 10.1016/S0735-1097(97)00191-5 |
| format | Article |
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Background. Arterial stiffness is an emerging risk marker for coronary heart disease and is potentially modifiable. Postmenopausal use of hormonal therapy is associated with a lower risk of coronary heart disease.
Methods. Total systemic arterial compliance (SAC) and pulse wave velocity (PWV) were determined in 26 premenopausal and 52 postmenopausal women, 26 of whom were taking hormonal therapy.
Results. Arterial compliance was greater in the premenopausal group (mean ± SEM 0.57 ± 0.04 arbitrary compliance units [ACU]) than in the postmenopausal group not taking hormonal therapy (0.26 ± 0.02 ACU, p = 0.001). Postmenopausal women taking hormonal therapy had a significantly increased total SAC compared with women not taking hormonal therapy (0.43 ± 0.02 vs. 0.26 ± 0.02 ACU, p = 0.001). PWV in the aortofemoral region in the premenopausal women was 6.0 ± 0.2 vs. 8.9 ± 0.3 m/s (p < 0.001) in untreated postmenopausal women. However, postmenopausal women taking hormonal therapy had a significantly lower PWV than those not taking hormonal therapy (7.9 ± 0.2 vs. 8.9 ± 0.3 m/s, p = 0.01). Eleven postmenopausal women had their hormone replacement therapy withdrawn for 4 weeks, resulting in a significant decrease in SAC and a significant increase in aortofemoral PWV.
Conclusions. The increased SAC and decreased PWV in women receiving hormonal therapy suggest that such therapy may decrease stiffness of the aorta and large arteries in postmenopausal women, with potential benefit for age-related cardiovascular disorders. The reduction of arterial compliance with age appears to be altered with hormonal therapy.</description><identifier>ISSN: 0735-1097</identifier><identifier>EISSN: 1558-3597</identifier><identifier>DOI: 10.1016/S0735-1097(97)00191-5</identifier><identifier>PMID: 9247504</identifier><identifier>CODEN: JACCDI</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adolescent ; Aged ; Arteries - drug effects ; Arteries - physiology ; Biological and medical sciences ; Compliance - drug effects ; Estrogen Replacement Therapy ; Female ; Hormones. Endocrine system ; Humans ; Medical sciences ; Middle Aged ; Pharmacology. Drug treatments ; Postmenopause - physiology</subject><ispartof>Journal of the American College of Cardiology, 1997-08, Vol.30 (2), p.350-356</ispartof><rights>1997 The American College of Cardiology</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c541t-38ced22e16e5da5fd6b250e727b443b46ad31329f92724cc2506bfe6810a80a83</citedby><cites>FETCH-LOGICAL-c541t-38ced22e16e5da5fd6b250e727b443b46ad31329f92724cc2506bfe6810a80a83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0735-1097(97)00191-5$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2755937$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9247504$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rajkumar, Chakravarthi</creatorcontrib><creatorcontrib>Kingwell, Bronwyn A.</creatorcontrib><creatorcontrib>Cameron, James D.</creatorcontrib><creatorcontrib>Waddell, Tamara</creatorcontrib><creatorcontrib>Mehra, Rishi</creatorcontrib><creatorcontrib>Christophidis, Nicholas</creatorcontrib><creatorcontrib>Komesaroff, Paul A.</creatorcontrib><creatorcontrib>McGrath, Barry</creatorcontrib><creatorcontrib>Jennings, Garry L.</creatorcontrib><creatorcontrib>Sudhir, Krishnankutty</creatorcontrib><creatorcontrib>Dart, Anthony M.</creatorcontrib><title>Hormonal Therapy Increases Arterial Compliance in Postmenopausal Women</title><title>Journal of the American College of Cardiology</title><addtitle>J Am Coll Cardiol</addtitle><description>Objectives. This study investigated the effects of hormonal therapy on large arterial properties.
Background. Arterial stiffness is an emerging risk marker for coronary heart disease and is potentially modifiable. Postmenopausal use of hormonal therapy is associated with a lower risk of coronary heart disease.
Methods. Total systemic arterial compliance (SAC) and pulse wave velocity (PWV) were determined in 26 premenopausal and 52 postmenopausal women, 26 of whom were taking hormonal therapy.
Results. Arterial compliance was greater in the premenopausal group (mean ± SEM 0.57 ± 0.04 arbitrary compliance units [ACU]) than in the postmenopausal group not taking hormonal therapy (0.26 ± 0.02 ACU, p = 0.001). Postmenopausal women taking hormonal therapy had a significantly increased total SAC compared with women not taking hormonal therapy (0.43 ± 0.02 vs. 0.26 ± 0.02 ACU, p = 0.001). PWV in the aortofemoral region in the premenopausal women was 6.0 ± 0.2 vs. 8.9 ± 0.3 m/s (p < 0.001) in untreated postmenopausal women. However, postmenopausal women taking hormonal therapy had a significantly lower PWV than those not taking hormonal therapy (7.9 ± 0.2 vs. 8.9 ± 0.3 m/s, p = 0.01). Eleven postmenopausal women had their hormone replacement therapy withdrawn for 4 weeks, resulting in a significant decrease in SAC and a significant increase in aortofemoral PWV.
Conclusions. The increased SAC and decreased PWV in women receiving hormonal therapy suggest that such therapy may decrease stiffness of the aorta and large arteries in postmenopausal women, with potential benefit for age-related cardiovascular disorders. The reduction of arterial compliance with age appears to be altered with hormonal therapy.</description><subject>Adolescent</subject><subject>Aged</subject><subject>Arteries - drug effects</subject><subject>Arteries - physiology</subject><subject>Biological and medical sciences</subject><subject>Compliance - drug effects</subject><subject>Estrogen Replacement Therapy</subject><subject>Female</subject><subject>Hormones. Endocrine system</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Postmenopause - physiology</subject><issn>0735-1097</issn><issn>1558-3597</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LxDAQhoMoun78BKEHET1U89k0J1kWdRcEBVc8hjSdYqRtatIV_Pdm3WWvwkAY3mcmw4PQOcE3BJPi9hVLJnKClbxS8hpjokgu9tCECFHmTCi5jyY75Agdx_iJMS5Kog7RoaJcCswn6GHuQ-d702bLDwhm-MkWvQ1gIsRsGkYILkUz3w2tM72FzPXZi49jB70fzCqm8N2n5hQdNKaNcLZ9T9Dbw_1yNs-fnh8Xs-lTbgUnY85KCzWlQAoQtRFNXVRUYJBUVpyzihemZoRR1SgqKbc2hUXVQDoamzIVO0GXm71D8F8riKPuXLTQtqYHv4paKlKUnLEEig1og48xQKOH4DoTfjTBeu1P__nTazk61Z8_LdLc-faDVdVBvZvaCkv5xTY30Zq2CcmKizuMSiEUkwm722CQZHw7CDpaB0lg7QLYUdfe_XPIL4QUi-s</recordid><startdate>19970801</startdate><enddate>19970801</enddate><creator>Rajkumar, Chakravarthi</creator><creator>Kingwell, Bronwyn A.</creator><creator>Cameron, James D.</creator><creator>Waddell, Tamara</creator><creator>Mehra, Rishi</creator><creator>Christophidis, Nicholas</creator><creator>Komesaroff, Paul A.</creator><creator>McGrath, Barry</creator><creator>Jennings, Garry L.</creator><creator>Sudhir, Krishnankutty</creator><creator>Dart, Anthony M.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19970801</creationdate><title>Hormonal Therapy Increases Arterial Compliance in Postmenopausal Women</title><author>Rajkumar, Chakravarthi ; Kingwell, Bronwyn A. ; Cameron, James D. ; Waddell, Tamara ; Mehra, Rishi ; Christophidis, Nicholas ; Komesaroff, Paul A. ; McGrath, Barry ; Jennings, Garry L. ; Sudhir, Krishnankutty ; Dart, Anthony M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c541t-38ced22e16e5da5fd6b250e727b443b46ad31329f92724cc2506bfe6810a80a83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adolescent</topic><topic>Aged</topic><topic>Arteries - drug effects</topic><topic>Arteries - physiology</topic><topic>Biological and medical sciences</topic><topic>Compliance - drug effects</topic><topic>Estrogen Replacement Therapy</topic><topic>Female</topic><topic>Hormones. Endocrine system</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Postmenopause - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rajkumar, Chakravarthi</creatorcontrib><creatorcontrib>Kingwell, Bronwyn A.</creatorcontrib><creatorcontrib>Cameron, James D.</creatorcontrib><creatorcontrib>Waddell, Tamara</creatorcontrib><creatorcontrib>Mehra, Rishi</creatorcontrib><creatorcontrib>Christophidis, Nicholas</creatorcontrib><creatorcontrib>Komesaroff, Paul A.</creatorcontrib><creatorcontrib>McGrath, Barry</creatorcontrib><creatorcontrib>Jennings, Garry L.</creatorcontrib><creatorcontrib>Sudhir, Krishnankutty</creatorcontrib><creatorcontrib>Dart, Anthony M.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American College of Cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rajkumar, Chakravarthi</au><au>Kingwell, Bronwyn A.</au><au>Cameron, James D.</au><au>Waddell, Tamara</au><au>Mehra, Rishi</au><au>Christophidis, Nicholas</au><au>Komesaroff, Paul A.</au><au>McGrath, Barry</au><au>Jennings, Garry L.</au><au>Sudhir, Krishnankutty</au><au>Dart, Anthony M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hormonal Therapy Increases Arterial Compliance in Postmenopausal Women</atitle><jtitle>Journal of the American College of Cardiology</jtitle><addtitle>J Am Coll Cardiol</addtitle><date>1997-08-01</date><risdate>1997</risdate><volume>30</volume><issue>2</issue><spage>350</spage><epage>356</epage><pages>350-356</pages><issn>0735-1097</issn><eissn>1558-3597</eissn><coden>JACCDI</coden><abstract>Objectives. This study investigated the effects of hormonal therapy on large arterial properties.
Background. Arterial stiffness is an emerging risk marker for coronary heart disease and is potentially modifiable. Postmenopausal use of hormonal therapy is associated with a lower risk of coronary heart disease.
Methods. Total systemic arterial compliance (SAC) and pulse wave velocity (PWV) were determined in 26 premenopausal and 52 postmenopausal women, 26 of whom were taking hormonal therapy.
Results. Arterial compliance was greater in the premenopausal group (mean ± SEM 0.57 ± 0.04 arbitrary compliance units [ACU]) than in the postmenopausal group not taking hormonal therapy (0.26 ± 0.02 ACU, p = 0.001). Postmenopausal women taking hormonal therapy had a significantly increased total SAC compared with women not taking hormonal therapy (0.43 ± 0.02 vs. 0.26 ± 0.02 ACU, p = 0.001). PWV in the aortofemoral region in the premenopausal women was 6.0 ± 0.2 vs. 8.9 ± 0.3 m/s (p < 0.001) in untreated postmenopausal women. However, postmenopausal women taking hormonal therapy had a significantly lower PWV than those not taking hormonal therapy (7.9 ± 0.2 vs. 8.9 ± 0.3 m/s, p = 0.01). Eleven postmenopausal women had their hormone replacement therapy withdrawn for 4 weeks, resulting in a significant decrease in SAC and a significant increase in aortofemoral PWV.
Conclusions. The increased SAC and decreased PWV in women receiving hormonal therapy suggest that such therapy may decrease stiffness of the aorta and large arteries in postmenopausal women, with potential benefit for age-related cardiovascular disorders. The reduction of arterial compliance with age appears to be altered with hormonal therapy.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>9247504</pmid><doi>10.1016/S0735-1097(97)00191-5</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of the American College of Cardiology, 1997-08, Vol.30 (2), p.350-356 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ScienceDirect Journals (5 years ago - present) |
| subjects | Adolescent Aged Arteries - drug effects Arteries - physiology Biological and medical sciences Compliance - drug effects Estrogen Replacement Therapy Female Hormones. Endocrine system Humans Medical sciences Middle Aged Pharmacology. Drug treatments Postmenopause - physiology |
| title | Hormonal Therapy Increases Arterial Compliance in Postmenopausal Women |
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