Release of PAF-acether and eicosanoids from guinea-pig alveolar macrophages by FMLP: effect of cyclo-oxygenase and lipoxygenase inhibition

Adherent guinea-pig alveolar macrophages stimulated in vitro with FMLP (1 μM) for 5–60 min released PAF-acether, TXB 2 and LTB 4, with maximal levels being achieved after a 5 min incubation. The levels of eicosanoids were maintained during the 60 min incubation period, whereas the levels of PAF-acet...

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Veröffentlicht in:	European journal of pharmacology 1989-05, Vol.164 (3), p.539-546
Hauptverfasser:	Fitzgerald, Mary F., Parente, Luca, Whittle, Brendan J.R.
Format:	Artikel
Sprache:	eng
Schlagworte:	4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine 5-Lipoxygenase inhibitors Alveolar macrophages Analytical, structural and metabolic biochemistry Animals Anti-Inflammatory Agents, Non-Steroidal Arachidonate Lipoxygenases - antagonists & inhibitors Benzeneacetamides Biological and medical sciences BW 137C BW 755C Cyclooxygenase Inhibitors Fundamental and applied biological sciences. Psychology Guinea Pigs Hydroxamic Acids - pharmacology In Vitro Techniques Indomethacin Indomethacin - pharmacology Leukotriene B 4 Leukotriene B4 - metabolism Lipids Lipoxygenase Inhibitors macrophages Macrophages - drug effects Macrophages - metabolism Male N-Formylmethionine Leucyl-Phenylalanine - pharmacology Other biological molecules Platelet activating factor (PAF-acether, PAF) Platelet Activating Factor - metabolism platelet-activating factor Pulmonary Alveoli - drug effects Pulmonary Alveoli - metabolism Pyrazoles - pharmacology Radioimmunoassay Thromboxane B 2 Thromboxane B2 - metabolism
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