Recombinant ATM protein complements the cellular A-T phenotype

Ataxia-telangiectasia (A-T) is an autosomal recessive disorder characterized by neurodegeneration, immunodeficiency, cancer predisposition, genome instability and radiation sensitivity. The cellular phenotype of A-T points to defects in signal transduction pathways involved in activation of cell cyc...

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Veröffentlicht in:	Oncogene 1997-07, Vol.15 (2), p.159-167
Hauptverfasser:	ZIV, Y, BAR-SHIRA, A, PECKER, I, RUSSELL, P, JORGENSEN, T. J, TSARFATI, I, SHILOH, Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Ataxia Ataxia telangiectasia mutated protein Ataxia Telangiectasia Mutated Proteins Biological and medical sciences Cell activation Cell cycle Cell Cycle Proteins Cell Line Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cloning, Molecular Cytoplasm DNA biosynthesis DNA-Binding Proteins Ectopic expression Epitopes Fundamental and applied biological sciences. Psychology Genomes Genomic instability Genotype & phenotype Hereditary diseases Humans Immunoblotting Immunodeficiency Immunoprecipitation Insect cells Ionizing radiation Lymphocytes Lymphocytes T Missense mutation Molecular and cellular biology Mutation Neurodegeneration Open Reading Frames Phenotype Phenotypes Post-irradiation Protein Biosynthesis Protein deficiency Protein-Serine-Threonine Kinases Proteins Proteins - analysis Proteins - physiology Rabbits Radiation Recombinant Proteins - analysis Recombinant Proteins - biosynthesis Signal transduction Spodoptera Tumor Suppressor Proteins Vectors
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