SPf66 malaria vaccine is safe and immunogenic in malaria naive adults in Thailand

In preparation for an efficacy trial of malaria vaccine SPf66 in Thailand, a series of overlapping Phase I trials were conducted of US-manufactured SPf66. Here, two clinical lots were evaluated for safety and immunogenicity in a combined open-label trial. Eleven healthy, malaria naive, 18–44 year-ol...

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Veröffentlicht in:	Acta tropica 1997-09, Vol.67 (3), p.215-227
Hauptverfasser:	Migasena, S, Heppner, D.G, Kyle, D.E, Chongsuphajaisiddhi, T, Gordon, D.M, Suntharasamai, P, Permpanich, B, Brockman, A, Pitiuttutham, P, Wongsrichanalai, C, Srisuriya, P, Phonrat, B, Pavanand, K, Viravan, C, Ballou, W.R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Animals Antibodies, Protozoan - blood Female Humans Lymphocyte Activation Malaria - prevention & control Malaria naive adults Malaria Vaccines - adverse effects Malaria Vaccines - immunology Male Plasmodium falciparum Plasmodium falciparum - immunology Protozoan Proteins - immunology Recombinant Proteins Sex Characteristics SPf66 malaria vaccine Thailand Vaccines, Synthetic - adverse effects Vaccines, Synthetic - immunology
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