Clinical biochemistry of neuron specific enolase

The soluble brain protein 14-3-2 first described by Moore and McGregor in 1965 is now known to be a cell specific isoenzyme of the glycolytic enzyme enolase (EC 4.2.1.11), designated neuron specific enolase (NSE). It is not only a marker for all types of neurons, but also for all neuroendocrine or p...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Clinica chimica acta 1989-07, Vol.183 (1), p.13-31
Hauptverfasser: Kaiser, E., Kuzmits, R., Pregant, P., Burghuber, O., Worofka, W.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 31
container_issue 1
container_start_page 13
container_title Clinica chimica acta
container_volume 183
creator Kaiser, E.
Kuzmits, R.
Pregant, P.
Burghuber, O.
Worofka, W.
description The soluble brain protein 14-3-2 first described by Moore and McGregor in 1965 is now known to be a cell specific isoenzyme of the glycolytic enzyme enolase (EC 4.2.1.11), designated neuron specific enolase (NSE). It is not only a marker for all types of neurons, but also for all neuroendocrine or paraneuronal cells. The appearance of NSE is a late event in neural differentiation, thus making NSE a useful index of neural maturation. The demonstration that tumors of the nervous system and of neuroendocrine origin contain NSE has promoted the study of NSE as a possible tumor marker. Immunocytochemistry has been used to identify NSE in cytologie preparations from several types of tumors, offering useful indications for differential diagnosis. NSE levels in serum from tumor patients are not useful in the diagnosis of early stage disease. However, serum NSE levels have been shown to be helpful in the identification of advanced small cell lung cancer, neuroblastoma and several other neoplasms. The main use of serum NSE is the monitoring of chemotherapy and the detection of a relapse in these cases.
doi_str_mv 10.1016/0009-8981(89)90268-4
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_79162069</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0009898189902684</els_id><sourcerecordid>79162069</sourcerecordid><originalsourceid>FETCH-LOGICAL-c357t-9902bbe8018b8a34f77e1e23db38c9e4826416c65dfe5166bdb8e10d8efdfd7c3</originalsourceid><addsrcrecordid>eNp9kMtKAzEUhoMotVbfQGFWoovRZCaTy0YoxRsU3Og6TJITjEwnNZkR-vamtnTp5hwO_39uH0KXBN8RTNg9xliWQgpyI-StxBUTJT1CUyJ4XdZUVsdoerCcorOUvnJJMSMTNKkaKjivpggvOt9703aF9sF8wsqnIW6K4Ioexhj6Iq3BeOdNAX3o2gTn6MS1XYKLfZ6hj6fH98VLuXx7fl3Ml6WpGz6UMh-kNQhMhBZtTR3nQKCqra6FkUBFxShhhjXWQUMY01YLINgKcNZZbuoZut7NXcfwPUIaVD7NQNe1PYQxKS4JqzCT2Uh3RhNDShGcWke_auNGEay2oNSWgtpSyEH9gVI0t13t5496BfbQtCeT9YedDvnJHw9RJeOhN2B9BDMoG_z_C34Bgot3Rw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>79162069</pqid></control><display><type>article</type><title>Clinical biochemistry of neuron specific enolase</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Kaiser, E. ; Kuzmits, R. ; Pregant, P. ; Burghuber, O. ; Worofka, W.</creator><creatorcontrib>Kaiser, E. ; Kuzmits, R. ; Pregant, P. ; Burghuber, O. ; Worofka, W.</creatorcontrib><description>The soluble brain protein 14-3-2 first described by Moore and McGregor in 1965 is now known to be a cell specific isoenzyme of the glycolytic enzyme enolase (EC 4.2.1.11), designated neuron specific enolase (NSE). It is not only a marker for all types of neurons, but also for all neuroendocrine or paraneuronal cells. The appearance of NSE is a late event in neural differentiation, thus making NSE a useful index of neural maturation. The demonstration that tumors of the nervous system and of neuroendocrine origin contain NSE has promoted the study of NSE as a possible tumor marker. Immunocytochemistry has been used to identify NSE in cytologie preparations from several types of tumors, offering useful indications for differential diagnosis. NSE levels in serum from tumor patients are not useful in the diagnosis of early stage disease. However, serum NSE levels have been shown to be helpful in the identification of advanced small cell lung cancer, neuroblastoma and several other neoplasms. The main use of serum NSE is the monitoring of chemotherapy and the detection of a relapse in these cases.</description><identifier>ISSN: 0009-8981</identifier><identifier>EISSN: 1873-3492</identifier><identifier>DOI: 10.1016/0009-8981(89)90268-4</identifier><identifier>PMID: 2548772</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Biomarkers, Tumor ; Carcinoma, Small Cell - diagnosis ; Humans ; Lung Neoplasms - diagnosis ; Neoplasms - diagnosis ; Neoplasms - enzymology ; Nervous System Diseases - diagnosis ; Nervous System Diseases - enzymology ; Neural differentiation ; Neuroblastoma ; Neuroblastoma - diagnosis ; Neuroendocrine and paraneuronal cell ; Neuron specific enolase ; Neurons - enzymology ; Phosphopyruvate Hydratase - blood ; Phosphopyruvate Hydratase - metabolism ; Prenatal Diagnosis ; Seminoma ; Small cell lung carcinoma ; Tumor marker</subject><ispartof>Clinica chimica acta, 1989-07, Vol.183 (1), p.13-31</ispartof><rights>1989</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-9902bbe8018b8a34f77e1e23db38c9e4826416c65dfe5166bdb8e10d8efdfd7c3</citedby><cites>FETCH-LOGICAL-c357t-9902bbe8018b8a34f77e1e23db38c9e4826416c65dfe5166bdb8e10d8efdfd7c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0009898189902684$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2548772$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kaiser, E.</creatorcontrib><creatorcontrib>Kuzmits, R.</creatorcontrib><creatorcontrib>Pregant, P.</creatorcontrib><creatorcontrib>Burghuber, O.</creatorcontrib><creatorcontrib>Worofka, W.</creatorcontrib><title>Clinical biochemistry of neuron specific enolase</title><title>Clinica chimica acta</title><addtitle>Clin Chim Acta</addtitle><description>The soluble brain protein 14-3-2 first described by Moore and McGregor in 1965 is now known to be a cell specific isoenzyme of the glycolytic enzyme enolase (EC 4.2.1.11), designated neuron specific enolase (NSE). It is not only a marker for all types of neurons, but also for all neuroendocrine or paraneuronal cells. The appearance of NSE is a late event in neural differentiation, thus making NSE a useful index of neural maturation. The demonstration that tumors of the nervous system and of neuroendocrine origin contain NSE has promoted the study of NSE as a possible tumor marker. Immunocytochemistry has been used to identify NSE in cytologie preparations from several types of tumors, offering useful indications for differential diagnosis. NSE levels in serum from tumor patients are not useful in the diagnosis of early stage disease. However, serum NSE levels have been shown to be helpful in the identification of advanced small cell lung cancer, neuroblastoma and several other neoplasms. The main use of serum NSE is the monitoring of chemotherapy and the detection of a relapse in these cases.</description><subject>Biomarkers, Tumor</subject><subject>Carcinoma, Small Cell - diagnosis</subject><subject>Humans</subject><subject>Lung Neoplasms - diagnosis</subject><subject>Neoplasms - diagnosis</subject><subject>Neoplasms - enzymology</subject><subject>Nervous System Diseases - diagnosis</subject><subject>Nervous System Diseases - enzymology</subject><subject>Neural differentiation</subject><subject>Neuroblastoma</subject><subject>Neuroblastoma - diagnosis</subject><subject>Neuroendocrine and paraneuronal cell</subject><subject>Neuron specific enolase</subject><subject>Neurons - enzymology</subject><subject>Phosphopyruvate Hydratase - blood</subject><subject>Phosphopyruvate Hydratase - metabolism</subject><subject>Prenatal Diagnosis</subject><subject>Seminoma</subject><subject>Small cell lung carcinoma</subject><subject>Tumor marker</subject><issn>0009-8981</issn><issn>1873-3492</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtKAzEUhoMotVbfQGFWoovRZCaTy0YoxRsU3Og6TJITjEwnNZkR-vamtnTp5hwO_39uH0KXBN8RTNg9xliWQgpyI-StxBUTJT1CUyJ4XdZUVsdoerCcorOUvnJJMSMTNKkaKjivpggvOt9703aF9sF8wsqnIW6K4Ioexhj6Iq3BeOdNAX3o2gTn6MS1XYKLfZ6hj6fH98VLuXx7fl3Ml6WpGz6UMh-kNQhMhBZtTR3nQKCqra6FkUBFxShhhjXWQUMY01YLINgKcNZZbuoZut7NXcfwPUIaVD7NQNe1PYQxKS4JqzCT2Uh3RhNDShGcWke_auNGEay2oNSWgtpSyEH9gVI0t13t5496BfbQtCeT9YedDvnJHw9RJeOhN2B9BDMoG_z_C34Bgot3Rw</recordid><startdate>19890731</startdate><enddate>19890731</enddate><creator>Kaiser, E.</creator><creator>Kuzmits, R.</creator><creator>Pregant, P.</creator><creator>Burghuber, O.</creator><creator>Worofka, W.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19890731</creationdate><title>Clinical biochemistry of neuron specific enolase</title><author>Kaiser, E. ; Kuzmits, R. ; Pregant, P. ; Burghuber, O. ; Worofka, W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-9902bbe8018b8a34f77e1e23db38c9e4826416c65dfe5166bdb8e10d8efdfd7c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Biomarkers, Tumor</topic><topic>Carcinoma, Small Cell - diagnosis</topic><topic>Humans</topic><topic>Lung Neoplasms - diagnosis</topic><topic>Neoplasms - diagnosis</topic><topic>Neoplasms - enzymology</topic><topic>Nervous System Diseases - diagnosis</topic><topic>Nervous System Diseases - enzymology</topic><topic>Neural differentiation</topic><topic>Neuroblastoma</topic><topic>Neuroblastoma - diagnosis</topic><topic>Neuroendocrine and paraneuronal cell</topic><topic>Neuron specific enolase</topic><topic>Neurons - enzymology</topic><topic>Phosphopyruvate Hydratase - blood</topic><topic>Phosphopyruvate Hydratase - metabolism</topic><topic>Prenatal Diagnosis</topic><topic>Seminoma</topic><topic>Small cell lung carcinoma</topic><topic>Tumor marker</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kaiser, E.</creatorcontrib><creatorcontrib>Kuzmits, R.</creatorcontrib><creatorcontrib>Pregant, P.</creatorcontrib><creatorcontrib>Burghuber, O.</creatorcontrib><creatorcontrib>Worofka, W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinica chimica acta</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kaiser, E.</au><au>Kuzmits, R.</au><au>Pregant, P.</au><au>Burghuber, O.</au><au>Worofka, W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical biochemistry of neuron specific enolase</atitle><jtitle>Clinica chimica acta</jtitle><addtitle>Clin Chim Acta</addtitle><date>1989-07-31</date><risdate>1989</risdate><volume>183</volume><issue>1</issue><spage>13</spage><epage>31</epage><pages>13-31</pages><issn>0009-8981</issn><eissn>1873-3492</eissn><abstract>The soluble brain protein 14-3-2 first described by Moore and McGregor in 1965 is now known to be a cell specific isoenzyme of the glycolytic enzyme enolase (EC 4.2.1.11), designated neuron specific enolase (NSE). It is not only a marker for all types of neurons, but also for all neuroendocrine or paraneuronal cells. The appearance of NSE is a late event in neural differentiation, thus making NSE a useful index of neural maturation. The demonstration that tumors of the nervous system and of neuroendocrine origin contain NSE has promoted the study of NSE as a possible tumor marker. Immunocytochemistry has been used to identify NSE in cytologie preparations from several types of tumors, offering useful indications for differential diagnosis. NSE levels in serum from tumor patients are not useful in the diagnosis of early stage disease. However, serum NSE levels have been shown to be helpful in the identification of advanced small cell lung cancer, neuroblastoma and several other neoplasms. The main use of serum NSE is the monitoring of chemotherapy and the detection of a relapse in these cases.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>2548772</pmid><doi>10.1016/0009-8981(89)90268-4</doi><tpages>19</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0009-8981
ispartof Clinica chimica acta, 1989-07, Vol.183 (1), p.13-31
issn 0009-8981
1873-3492
language eng
recordid cdi_proquest_miscellaneous_79162069
source MEDLINE; Elsevier ScienceDirect Journals
subjects Biomarkers, Tumor
Carcinoma, Small Cell - diagnosis
Humans
Lung Neoplasms - diagnosis
Neoplasms - diagnosis
Neoplasms - enzymology
Nervous System Diseases - diagnosis
Nervous System Diseases - enzymology
Neural differentiation
Neuroblastoma
Neuroblastoma - diagnosis
Neuroendocrine and paraneuronal cell
Neuron specific enolase
Neurons - enzymology
Phosphopyruvate Hydratase - blood
Phosphopyruvate Hydratase - metabolism
Prenatal Diagnosis
Seminoma
Small cell lung carcinoma
Tumor marker
title Clinical biochemistry of neuron specific enolase
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T00%3A45%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Clinical%20biochemistry%20of%20neuron%20specific%20enolase&rft.jtitle=Clinica%20chimica%20acta&rft.au=Kaiser,%20E.&rft.date=1989-07-31&rft.volume=183&rft.issue=1&rft.spage=13&rft.epage=31&rft.pages=13-31&rft.issn=0009-8981&rft.eissn=1873-3492&rft_id=info:doi/10.1016/0009-8981(89)90268-4&rft_dat=%3Cproquest_cross%3E79162069%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=79162069&rft_id=info:pmid/2548772&rft_els_id=0009898189902684&rfr_iscdi=true