Behavioural tolerance to morphine analgesia is supraspinally mediated: a quantitative analysis of dose-response relationships

Repeated exposure of a rat to a nociceptive testing environment (‘habituation’) enhances its sensitivity to noxious thermal stimuli 20 and reduces the antinociceptive effect of a subsequent acute dose of morphine (‘behavioural tolerance’). The present study quantitatively characterises the effects o...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Brain research 1989-07, Vol.491 (2), p.316-327
Hauptverfasser:	Milne, R.J., Gamble, G.D., Holford, N.H.G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesia Animals Behavior, Animal - drug effects Behavioral psychophysiology Behavioral tolerance Biological and medical sciences Brain - drug effects Brain - physiopathology Bulbospinal Decerebrate State Dose-response relationship Dose-Response Relationship, Drug Drug Tolerance Female Fundamental and applied biological sciences. Psychology Habituation Habituation, Psychophysiologic - drug effects Morphine Morphine - pharmacology Pain - physiopathology Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Inbred Strains Reaction Time - drug effects Sensory Thresholds - drug effects Spinal
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!