Müllerian agenesis: An update
Recently, many advances have been made in the study of sexual differentiation, including the discoveries of the gene for antimüllerian hormone as well as the gene for its receptor. However, the etiology of the clinical syndrome of müllerian agenesis remains elusive. We hypothesize that activating mu...
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| Veröffentlicht in: | Obstetrics and gynecology (New York. 1953) 1997-08, Vol.90 (2), p.307-312 |
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| container_title | Obstetrics and gynecology (New York. 1953) |
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| creator | Lindenman, Elizabeth Shepard, Marguerite K. Pescovitz, Ora Hirsch |
| description | Recently, many advances have been made in the study of sexual differentiation, including the discoveries of the gene for antimüllerian hormone as well as the gene for its receptor. However, the etiology of the clinical syndrome of müllerian agenesis remains elusive. We hypothesize that activating mutations of either the antimüllerian hormone gene or its receptor gene may cause müllerian duct regression in a genetic female during embryogenesis. This clinical commentary discusses the current management of the syndrome including the Abbe-Mclndoe procedure, the most commonly used method of surgical correction, and the Frank vaginal dilation method, the most common nonsurgical method of correction. |
| doi_str_mv | 10.1016/S0029-7844(97)00256-1 |
| format | Article |
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Obstetrics</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mullerian Ducts - abnormalities</subject><subject>Mutation</subject><subject>Non tumoral diseases</subject><subject>Sex Differentiation</subject><subject>Syndrome</subject><subject>Testicular Hormones - genetics</subject><subject>Vagina - abnormalities</subject><issn>0029-7844</issn><issn>1873-233X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAQhq0KVJbCTyjaA0JwCMzEiT-4oKriS2rVA63EzXLsSWvwJls7oeK_9dY_hre72isHazSa5_U78zJ2jPAeAcWHHwC1rqRqmrdavitNKyo8YAtUklc15z-fsMUeecae5_wLoAg1P2SHum6QY7Ngr84f7mOkFOywtNc0UA754_JkWM5rbyd6wZ72NmZ6uatH7OrL58vTb9XZxdfvpydnlWt4g1WvbdejEER9jR7brrVaSuC-Vs5z0NB0tuNce-6Vxx6sFlYpLYSkunNW8yP2ZvvvOo23M-XJrEJ2FKMdaJyzkRoFglAFbLegS2POiXqzTmFl01-DYDa5mMdczOZoo6V5zMVg0R3vDOZuRX6v2gVR5q93c5udjX2ygwt5j9VSKCmgYM0WuxvjRCn_jvMdJXNDNk43xQxA1C1UqLUEVbqqPL5x_7SVUcnwTyiK7AINjnxI5Cbjx_Cf_f8BtGGNCg</recordid><startdate>199708</startdate><enddate>199708</enddate><creator>Lindenman, Elizabeth</creator><creator>Shepard, Marguerite K.</creator><creator>Pescovitz, Ora Hirsch</creator><general>Elsevier Inc</general><general>The American College of Obstetricians and Gynecologists</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199708</creationdate><title>Müllerian agenesis: An update</title><author>Lindenman, Elizabeth ; Shepard, Marguerite K. ; Pescovitz, Ora Hirsch</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4341-f9abf166eef21d15b5a97703d28cd30904bab339d3d8d1f0a96a889667e2bca93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Anti-Mullerian Hormone</topic><topic>Biological and medical sciences</topic><topic>Congenital Abnormalities - surgery</topic><topic>Congenital Abnormalities - therapy</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Glycoproteins</topic><topic>Growth Inhibitors - genetics</topic><topic>Gynecology. 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Obstetrics</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mullerian Ducts - abnormalities</topic><topic>Mutation</topic><topic>Non tumoral diseases</topic><topic>Sex Differentiation</topic><topic>Syndrome</topic><topic>Testicular Hormones - genetics</topic><topic>Vagina - abnormalities</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lindenman, Elizabeth</creatorcontrib><creatorcontrib>Shepard, Marguerite K.</creatorcontrib><creatorcontrib>Pescovitz, Ora Hirsch</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lindenman, Elizabeth</au><au>Shepard, Marguerite K.</au><au>Pescovitz, Ora Hirsch</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Müllerian agenesis: An update</atitle><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle><addtitle>Obstet Gynecol</addtitle><date>1997-08</date><risdate>1997</risdate><volume>90</volume><issue>2</issue><spage>307</spage><epage>312</epage><pages>307-312</pages><issn>0029-7844</issn><eissn>1873-233X</eissn><coden>OBGNAS</coden><abstract>Recently, many advances have been made in the study of sexual differentiation, including the discoveries of the gene for antimüllerian hormone as well as the gene for its receptor. 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| ispartof | Obstetrics and gynecology (New York. 1953), 1997-08, Vol.90 (2), p.307-312 |
| issn | 0029-7844 1873-233X |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Anti-Mullerian Hormone Biological and medical sciences Congenital Abnormalities - surgery Congenital Abnormalities - therapy Female Female genital diseases Glycoproteins Growth Inhibitors - genetics Gynecology. Andrology. Obstetrics Humans Male Medical sciences Mullerian Ducts - abnormalities Mutation Non tumoral diseases Sex Differentiation Syndrome Testicular Hormones - genetics Vagina - abnormalities |
| title | Müllerian agenesis: An update |
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