Immunogenicity and efficacy of a tuberculosis DNA vaccine encoding the components of the secreted antigen 85 complex

BALB/c and C57BL/6 mice were injected intramuscularly with plasmid DNA encoding the three components of the immunodominant 30–32 kDa antigen 85 complex (Ag85A, Ag85B, and Ag85C) from Mycobacterium tuberculosis culture filtrate, in order to investigate the utility of nucleic acid vaccination for indu...

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Veröffentlicht in:	Vaccine 1997-06, Vol.15 (8), p.830-833
Hauptverfasser:	Lozes, Evelyne, Huygen, Kris, Content, Jean, Denis, Olivier, Montgomery, Donna L., Yawman, Anne M., Vandenbussche, Paul, Van Vooren, Jean-Paul, Drowart, Annie, Ulmer, Jeffrey B., Liu, Margaret A.
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Animals Antibodies, Bacterial - biosynthesis antigen 85 Antigens, Bacterial - genetics Antigens, Bacterial - immunology Applied microbiology Bacteriology BCG Vaccine - administration & dosage BCG Vaccine - genetics BCG Vaccine - immunology Biological and medical sciences Cell Division - drug effects Cytokines - biosynthesis DNA vaccine DNA, Bacterial - immunology Fundamental and applied biological sciences. Psychology Injections, Intramuscular Mice Mice, Inbred BALB C Mice, Inbred C57BL Microbiology Mycobacterium bovis - cytology Mycobacterium bovis - immunology Mycobacterium tuberculosis T-Lymphocytes, Cytotoxic - immunology Th1 Cells - immunology tuberculosis Tuberculosis - immunology Tuberculosis - prevention & control Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, DNA - administration & dosage Vaccines, DNA - genetics Vaccines, DNA - immunology
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