Screening for Down's syndrome: changes in marker levels and detection rates between first and second trimesters

Objective To monitor changes with gestation in levels of alpha‐fetoprotein (AFP), free beta human chorionic gonadotrophin (FβhCG) and pregnancy associated plasma protein‐A (PAPP‐A) in Down's syndrome pregnancies and to compare risks estimated in the first trimester with those obtained by routin...

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Veröffentlicht in:	BJOG : an international journal of obstetrics and gynaecology 1997-07, Vol.104 (7), p.811-817
Hauptverfasser:	Berry, Esther, Aitken, David A., Crossley, Jennifer A., Macri, James N., Connor, J. Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Fetoproteins - metabolism Biological and medical sciences Biomarkers - analysis Chorionic Gonadotropin, beta Subunit, Human - metabolism Down Syndrome - blood Down Syndrome - prevention & control Female Gynecology. Andrology. Obstetrics Humans Likelihood Functions Management. Prenatal diagnosis Maternal Age Medical sciences Pregnancy Pregnancy Trimester, First Pregnancy Trimester, Second Pregnancy-Associated Plasma Protein-A - metabolism Pregnancy. Fetus. Placenta Prenatal Diagnosis - methods Risk Assessment Sensitivity and Specificity
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