Cerebral haemoglobin oxygenation during sustained visual stimulation – a near–infrared spectroscopy study
It is important to consider the time–course of haemoglobin oxygenation when interpreting functional activation data, especially those data obtained with oxygenation–sensitive methods, such as BOLD contrast fMRI.
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| Veröffentlicht in: | Philosophical transactions of the Royal Society of London. Series B. Biological sciences 1997-06, Vol.352 (1354), p.743-750 |
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| container_title | Philosophical transactions of the Royal Society of London. Series B. Biological sciences |
| container_volume | 352 |
| creator | Heekeren, H. R. Obrig, H. Wenzel, R. Eberle, K. Ruben, J. Villringer, K. Kurth, R. Villringer, A. |
| description | It is important to consider the time–course of haemoglobin oxygenation when interpreting functional activation data, especially
those data obtained with oxygenation–sensitive methods, such as BOLD contrast fMRI. |
| doi_str_mv | 10.1098/rstb.1997.0057 |
| format | Article |
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those data obtained with oxygenation–sensitive methods, such as BOLD contrast fMRI.</description><description>The concentration of oxyhaemoglobin increased upon functional activation. However, in the mean across all subjects there was
no initial overshoot. After approximately 19 s it reached a plateau and remained constantly elevated throughout the activation
period. After cessation of activation there was a ‘post–stimulus undershoot’ of oxyhaemoglobin.</description><description>Using near–infrared spectroscopy, we investigated the time–course of the concentrations of oxygenated haemoglobin, [oxy–Hb],
and deoxygenated haemoglobin, [deoxy–Hb], in the occipital cortex of healthy human adults during sustained visual stimulation.
Within a few seconds after stimulation (coloured dodecahedrons) we observed a decrease in [deoxy–Hb], peaking after 13 s (‘initial
undershoot’). In the subsequent 1–2 min, in seven out of ten subjects, [deoxy–Hb] gradually returned to a plateau closer to
the baseline level. After cessation of stimulation, there was a ‘post–stimulus overshoot’ in the concentration of deoxyhaemoglobin.
There was a statistically significant correlation between the size of the ‘initial undershoot’ and the ‘post–stimulus overshoot’.</description><identifier>ISSN: 0962-8436</identifier><identifier>EISSN: 1471-2970</identifier><identifier>DOI: 10.1098/rstb.1997.0057</identifier><identifier>PMID: 9232863</identifier><language>eng</language><publisher>England: The Royal Society</publisher><subject>Adult ; Adults ; Arithmetic mean ; Attenuation coefficients ; Chromophores ; Color Perception ; Female ; Hemoglobins - metabolism ; Humans ; Kinetics ; Magnetic resonance imaging ; Male ; Occipital Lobe - blood supply ; Occipital Lobe - metabolism ; Oxyhemoglobins - metabolism ; Photic Stimulation ; Radio spectroscopy ; Regression Analysis ; Spectrophotometry, Infrared - methods ; Statistical significance ; T tests ; Tissue oxygenation ; Visual stimulation</subject><ispartof>Philosophical transactions of the Royal Society of London. Series B. Biological sciences, 1997-06, Vol.352 (1354), p.743-750</ispartof><rights>Copyright 1997 The Royal Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c720t-b550c59d92ca72514a777b079aea5c89d18e3144613a97510c621fee74e46a193</citedby><cites>FETCH-LOGICAL-c720t-b550c59d92ca72514a777b079aea5c89d18e3144613a97510c621fee74e46a193</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/56510$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/56510$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,724,777,781,800,882,27905,27906,53772,53774,57998,58231</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9232863$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Cooper, C. E.</contributor><contributor>Chance, B.</contributor><contributor>Delpy, D. T.</contributor><contributor>Reynolds, E. O. R.</contributor><contributor>Chance, B.</contributor><contributor>Cooper, C. E.</contributor><contributor>Delpy, D. T.</contributor><contributor>Reynolds, E. O. R.</contributor><creatorcontrib>Heekeren, H. R.</creatorcontrib><creatorcontrib>Obrig, H.</creatorcontrib><creatorcontrib>Wenzel, R.</creatorcontrib><creatorcontrib>Eberle, K.</creatorcontrib><creatorcontrib>Ruben, J.</creatorcontrib><creatorcontrib>Villringer, K.</creatorcontrib><creatorcontrib>Kurth, R.</creatorcontrib><creatorcontrib>Villringer, A.</creatorcontrib><title>Cerebral haemoglobin oxygenation during sustained visual stimulation – a near–infrared spectroscopy study</title><title>Philosophical transactions of the Royal Society of London. Series B. Biological sciences</title><addtitle>Philos Trans R Soc Lond B Biol Sci</addtitle><description>It is important to consider the time–course of haemoglobin oxygenation when interpreting functional activation data, especially
those data obtained with oxygenation–sensitive methods, such as BOLD contrast fMRI.</description><description>The concentration of oxyhaemoglobin increased upon functional activation. However, in the mean across all subjects there was
no initial overshoot. After approximately 19 s it reached a plateau and remained constantly elevated throughout the activation
period. After cessation of activation there was a ‘post–stimulus undershoot’ of oxyhaemoglobin.</description><description>Using near–infrared spectroscopy, we investigated the time–course of the concentrations of oxygenated haemoglobin, [oxy–Hb],
and deoxygenated haemoglobin, [deoxy–Hb], in the occipital cortex of healthy human adults during sustained visual stimulation.
Within a few seconds after stimulation (coloured dodecahedrons) we observed a decrease in [deoxy–Hb], peaking after 13 s (‘initial
undershoot’). In the subsequent 1–2 min, in seven out of ten subjects, [deoxy–Hb] gradually returned to a plateau closer to
the baseline level. After cessation of stimulation, there was a ‘post–stimulus overshoot’ in the concentration of deoxyhaemoglobin.
There was a statistically significant correlation between the size of the ‘initial undershoot’ and the ‘post–stimulus overshoot’.</description><subject>Adult</subject><subject>Adults</subject><subject>Arithmetic mean</subject><subject>Attenuation coefficients</subject><subject>Chromophores</subject><subject>Color Perception</subject><subject>Female</subject><subject>Hemoglobins - metabolism</subject><subject>Humans</subject><subject>Kinetics</subject><subject>Magnetic resonance imaging</subject><subject>Male</subject><subject>Occipital Lobe - blood supply</subject><subject>Occipital Lobe - metabolism</subject><subject>Oxyhemoglobins - metabolism</subject><subject>Photic Stimulation</subject><subject>Radio spectroscopy</subject><subject>Regression Analysis</subject><subject>Spectrophotometry, Infrared - methods</subject><subject>Statistical significance</subject><subject>T tests</subject><subject>Tissue oxygenation</subject><subject>Visual stimulation</subject><issn>0962-8436</issn><issn>1471-2970</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9ks2O0zAUhSMEGsrAlgUSUlbsUuzYjuMNCMq_RgKGYcTOchyndUnsYDtlyop34A15EpymqqgQs4qt-917z_FJktyHYA4BKx87H6o5ZIzOASD0RjKDmMIsZxTcTGaAFXlWYlTcTu54vwYAMELxSXLCcpSXBZol3UI5VTnRpiuhOrtsbaVNaq-2S2VE0Nak9eC0WaZ-8EFoo-p0o_0QeR90N7QT8_vnr1SkRgkXT9o0TrgI-l7J4KyXtt9GfKi3d5NbjWi9urf_niafX728WLzJzt6_frt4dpZJmoOQVYQASVjNciloTiAWlNIKUCaUILJkNSwVghgXEAlGCQSyyGGjFMUKFwIydJo8meb2Q9WpWioTokXeO90Jt-VWaH5cMXrFl3bDYcEgK0Ac8Gg_wNlvg_KBd9pL1bbCKDt4ThkkRQnKCM4nUEaj3qnmsAQCPgbEx4D4GBAfA4oND_-WdsD3icS6n-rObuMTWalV2PK1HZyJV37-6eJ5HAY2iOQaIoJ5FAEBRgQA_kP3u3UjwCPAtfeD4jvsWMa_qtB1W__r5cHUtfbBuoMVUsRIYjGbitoHdXUoCveVFxRRwi9LzC9f4C_k3Ydz_jHyYOJXern6rp3iR1ripY_LR1c7PxSPb_X02pZRrbQmxJCPGnkztPFvqBv0B_x1CI4</recordid><startdate>19970629</startdate><enddate>19970629</enddate><creator>Heekeren, H. 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R.</creatorcontrib><creatorcontrib>Obrig, H.</creatorcontrib><creatorcontrib>Wenzel, R.</creatorcontrib><creatorcontrib>Eberle, K.</creatorcontrib><creatorcontrib>Ruben, J.</creatorcontrib><creatorcontrib>Villringer, K.</creatorcontrib><creatorcontrib>Kurth, R.</creatorcontrib><creatorcontrib>Villringer, A.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Philosophical transactions of the Royal Society of London. Series B. Biological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Heekeren, H. R.</au><au>Obrig, H.</au><au>Wenzel, R.</au><au>Eberle, K.</au><au>Ruben, J.</au><au>Villringer, K.</au><au>Kurth, R.</au><au>Villringer, A.</au><au>Cooper, C. E.</au><au>Chance, B.</au><au>Delpy, D. T.</au><au>Reynolds, E. O. R.</au><au>Chance, B.</au><au>Cooper, C. E.</au><au>Delpy, D. T.</au><au>Reynolds, E. O. R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cerebral haemoglobin oxygenation during sustained visual stimulation – a near–infrared spectroscopy study</atitle><jtitle>Philosophical transactions of the Royal Society of London. Series B. Biological sciences</jtitle><addtitle>Philos Trans R Soc Lond B Biol Sci</addtitle><date>1997-06-29</date><risdate>1997</risdate><volume>352</volume><issue>1354</issue><spage>743</spage><epage>750</epage><pages>743-750</pages><issn>0962-8436</issn><eissn>1471-2970</eissn><abstract>It is important to consider the time–course of haemoglobin oxygenation when interpreting functional activation data, especially
those data obtained with oxygenation–sensitive methods, such as BOLD contrast fMRI.</abstract><abstract>The concentration of oxyhaemoglobin increased upon functional activation. However, in the mean across all subjects there was
no initial overshoot. After approximately 19 s it reached a plateau and remained constantly elevated throughout the activation
period. After cessation of activation there was a ‘post–stimulus undershoot’ of oxyhaemoglobin.</abstract><abstract>Using near–infrared spectroscopy, we investigated the time–course of the concentrations of oxygenated haemoglobin, [oxy–Hb],
and deoxygenated haemoglobin, [deoxy–Hb], in the occipital cortex of healthy human adults during sustained visual stimulation.
Within a few seconds after stimulation (coloured dodecahedrons) we observed a decrease in [deoxy–Hb], peaking after 13 s (‘initial
undershoot’). In the subsequent 1–2 min, in seven out of ten subjects, [deoxy–Hb] gradually returned to a plateau closer to
the baseline level. After cessation of stimulation, there was a ‘post–stimulus overshoot’ in the concentration of deoxyhaemoglobin.
There was a statistically significant correlation between the size of the ‘initial undershoot’ and the ‘post–stimulus overshoot’.</abstract><cop>England</cop><pub>The Royal Society</pub><pmid>9232863</pmid><doi>10.1098/rstb.1997.0057</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0962-8436 |
| ispartof | Philosophical transactions of the Royal Society of London. Series B. Biological sciences, 1997-06, Vol.352 (1354), p.743-750 |
| issn | 0962-8436 1471-2970 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79156808 |
| source | MEDLINE; Jstor Complete Legacy; PubMed Central |
| subjects | Adult Adults Arithmetic mean Attenuation coefficients Chromophores Color Perception Female Hemoglobins - metabolism Humans Kinetics Magnetic resonance imaging Male Occipital Lobe - blood supply Occipital Lobe - metabolism Oxyhemoglobins - metabolism Photic Stimulation Radio spectroscopy Regression Analysis Spectrophotometry, Infrared - methods Statistical significance T tests Tissue oxygenation Visual stimulation |
| title | Cerebral haemoglobin oxygenation during sustained visual stimulation – a near–infrared spectroscopy study |
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