The Rabbit VX2 Tumour as a Model for Carcinomas of the Tongue and Larynx
Animal models of carcinomas can provide useful information for the evaluation of new treatments. In the rabbit, the VX2 tumour is a fast growing, transplantable squamous cell carcinoma. By implanting a cell suspension of the tumour into the tongue and/or the larynx, a useful new model for studying o...
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| Veröffentlicht in: | Acta oto-laryngologica 1989, Vol.108 (1-2), p.152-160 |
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| container_title | Acta oto-laryngologica |
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| creator | Jefferis, A. F. Berenbaum, M. C. |
| description | Animal models of carcinomas can provide useful information for the evaluation of new treatments. In the rabbit, the VX2 tumour is a fast growing, transplantable squamous cell carcinoma. By implanting a cell suspension of the tumour into the tongue and/or the larynx, a useful new model for studying or treating tumours in this region has been developed. The tumours were evaluated histologically and showed features consistent with human carcinomas, including surface ulceration, lymphatic spread and encroachment of the airway. The VX2 tumours in these sites have features which offer advantages over existing models. These include the ability to study several sites of tumour growth in the same animal, to follow rapidly growing tumours, storage of the tumour in liquid nitrogen allowing experiments to be started when convenient, and the large size of the rabbit larynx which permits considerable tumour growth before airway embarrassment. |
| doi_str_mv | 10.3109/00016488909107407 |
| format | Article |
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These include the ability to study several sites of tumour growth in the same animal, to follow rapidly growing tumours, storage of the tumour in liquid nitrogen allowing experiments to be started when convenient, and the large size of the rabbit larynx which permits considerable tumour growth before airway embarrassment.</description><identifier>ISSN: 0001-6489</identifier><identifier>EISSN: 1651-2251</identifier><identifier>DOI: 10.3109/00016488909107407</identifier><identifier>PMID: 2763834</identifier><identifier>CODEN: AOLAAJ</identifier><language>eng</language><publisher>Stockholm: Informa UK Ltd</publisher><subject>Animal tumors. Experimental tumors ; Animals ; Biological and medical sciences ; Carcinoma, Squamous Cell - pathology ; Disease Models, Animal ; Experimental head and neck tumors. 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F.</creatorcontrib><creatorcontrib>Berenbaum, M. C.</creatorcontrib><title>The Rabbit VX2 Tumour as a Model for Carcinomas of the Tongue and Larynx</title><title>Acta oto-laryngologica</title><addtitle>Acta Otolaryngol</addtitle><description>Animal models of carcinomas can provide useful information for the evaluation of new treatments. In the rabbit, the VX2 tumour is a fast growing, transplantable squamous cell carcinoma. By implanting a cell suspension of the tumour into the tongue and/or the larynx, a useful new model for studying or treating tumours in this region has been developed. The tumours were evaluated histologically and showed features consistent with human carcinomas, including surface ulceration, lymphatic spread and encroachment of the airway. The VX2 tumours in these sites have features which offer advantages over existing models. These include the ability to study several sites of tumour growth in the same animal, to follow rapidly growing tumours, storage of the tumour in liquid nitrogen allowing experiments to be started when convenient, and the large size of the rabbit larynx which permits considerable tumour growth before airway embarrassment.</description><subject>Animal tumors. Experimental tumors</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Disease Models, Animal</subject><subject>Experimental head and neck tumors. Experimental orbital tumors</subject><subject>implantation</subject><subject>Laryngeal Neoplasms - pathology</subject><subject>Larynx - pathology</subject><subject>Medical sciences</subject><subject>Neoplasm Transplantation</subject><subject>Rabbits</subject><subject>Tongue - pathology</subject><subject>Tongue Neoplasms - pathology</subject><subject>Tumors</subject><issn>0001-6489</issn><issn>1651-2251</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kVtL7DAUhYMoOl5-gA9CHuS8VXNvguflMHiDEUFG8a3spqlTaRtP0qL-ezPMKIjgU0jWtxZ7ryB0SMkJp8ScEkKoElobYijJBck30IQqSTPGJN1Ek6WeJcDsoN0Yn5dXo-U22ma54pqLCbqaLxy-g7JsBvzwyPB87PwYMEQM-MZXrsW1D3gKwTa979Kzr_GQLHPfP40OQ1_hGYT3_m0fbdXQRnewPvfQ_cX5fHqVzW4vr6f_ZpnlQg4ZUCMqwwUVlQMDUpV5LfNKaeUE5UpKzaSwZW6plooZq63jmlGpasK5tMD30J9V7kvw_0cXh6JronVtC73zYyxyk2AiWQLpCrTBxxhcXbyEpkuzFpQUy_aKH-0lz9E6fCw7V3051nUl_XitQ7TQ1gF628QvLGeaprSE_V1hTZ_a6-DVh7YqBnhvffj08N-mOPtmXzhoh4WF4Irn9Dl9qveXHT4AXOaY3g</recordid><startdate>1989</startdate><enddate>1989</enddate><creator>Jefferis, A. 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Experimental tumors</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Disease Models, Animal</topic><topic>Experimental head and neck tumors. Experimental orbital tumors</topic><topic>implantation</topic><topic>Laryngeal Neoplasms - pathology</topic><topic>Larynx - pathology</topic><topic>Medical sciences</topic><topic>Neoplasm Transplantation</topic><topic>Rabbits</topic><topic>Tongue - pathology</topic><topic>Tongue Neoplasms - pathology</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jefferis, A. F.</creatorcontrib><creatorcontrib>Berenbaum, M. C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>Acta oto-laryngologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jefferis, A. F.</au><au>Berenbaum, M. C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Rabbit VX2 Tumour as a Model for Carcinomas of the Tongue and Larynx</atitle><jtitle>Acta oto-laryngologica</jtitle><addtitle>Acta Otolaryngol</addtitle><date>1989</date><risdate>1989</risdate><volume>108</volume><issue>1-2</issue><spage>152</spage><epage>160</epage><pages>152-160</pages><issn>0001-6489</issn><eissn>1651-2251</eissn><coden>AOLAAJ</coden><abstract>Animal models of carcinomas can provide useful information for the evaluation of new treatments. In the rabbit, the VX2 tumour is a fast growing, transplantable squamous cell carcinoma. By implanting a cell suspension of the tumour into the tongue and/or the larynx, a useful new model for studying or treating tumours in this region has been developed. The tumours were evaluated histologically and showed features consistent with human carcinomas, including surface ulceration, lymphatic spread and encroachment of the airway. The VX2 tumours in these sites have features which offer advantages over existing models. These include the ability to study several sites of tumour growth in the same animal, to follow rapidly growing tumours, storage of the tumour in liquid nitrogen allowing experiments to be started when convenient, and the large size of the rabbit larynx which permits considerable tumour growth before airway embarrassment.</abstract><cop>Stockholm</cop><pub>Informa UK Ltd</pub><pmid>2763834</pmid><doi>10.3109/00016488909107407</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0001-6489 |
| ispartof | Acta oto-laryngologica, 1989, Vol.108 (1-2), p.152-160 |
| issn | 0001-6489 1651-2251 |
| language | eng |
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| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | Animal tumors. Experimental tumors Animals Biological and medical sciences Carcinoma, Squamous Cell - pathology Disease Models, Animal Experimental head and neck tumors. Experimental orbital tumors implantation Laryngeal Neoplasms - pathology Larynx - pathology Medical sciences Neoplasm Transplantation Rabbits Tongue - pathology Tongue Neoplasms - pathology Tumors |
| title | The Rabbit VX2 Tumour as a Model for Carcinomas of the Tongue and Larynx |
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