Human neutrophil elastase activates human factor V but inactivates thrombin-activated human factor V

The effect of human neutrophil elastase (HNE) on human factor V (F.V) or alpha-thrombin-activated human factor V (F.Va) was studied in vitro by prothrombinase assays, sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), and NH2-terminal sequence analysis. Incubation of F.V (600 nmol...

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Veröffentlicht in:	Blood 1997-08, Vol.90 (3), p.1065-1074
Hauptverfasser:	SAMIS, J. A, GARRETT, M, MANUEL, R. P, NESHEIM, M. E, GILES, A. R
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Blood coagulation. Blood cells Calcium - metabolism Coagulation factors Enzyme Activation Factor V - chemistry Factor V - metabolism Factor Va - antagonists & inhibitors Factor X - metabolism Factor Xa Fundamental and applied biological sciences. Psychology Humans Leukocyte Elastase - physiology Molecular and cellular biology Neutrophils - enzymology Peptide Fragments - analysis Thrombin - physiology
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