Human Immunodeficiency Virus Type 1 gp41 Binds to Candida albicans via Complement C3-like Regions
Oral candidiasis in human immunodeficiency virus type 1 (HIV-1)-infected persons is believed to be caused by the acquired T lymphocyte immunodeficiency. The direct interaction of C. albicans and HIV-1 in vitro was investigated. Twice as many yeasts adhered to cells transfected with the HIV-1 env gen...
Gespeichert in:
| Veröffentlicht in: | The Journal of infectious diseases 1997-08, Vol.176 (2), p.492-498 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 498 |
|---|---|
| container_issue | 2 |
| container_start_page | 492 |
| container_title | The Journal of infectious diseases |
| container_volume | 176 |
| creator | Würzner, Reinhard Gruber, Andreas Stoiber, Heribert Spruth, Martin Chen, Ying-Hua Lukasser-Vogl, Elisabeth Schwendinger, Michael G. Dierich, Manfred P. |
| description | Oral candidiasis in human immunodeficiency virus type 1 (HIV-1)-infected persons is believed to be caused by the acquired T lymphocyte immunodeficiency. The direct interaction of C. albicans and HIV-1 in vitro was investigated. Twice as many yeasts adhered to cells transfected with the HIV-1 env gene as they did to controls. HIV-1 rsgpl60 and rsgp41 but not rsgpl20 were found to bind to Candida albicans via two C3-like regions within gp41. Normal human serum, but not C3depleted serum, was able to inhibit rsgp41 binding to C. albicans. Vice versa, rsgpl60 and rsgp41 were able to block resetting of C. albicans with iC3b-coated sheep erythrocytes. Binding to C. albicans, and its inhibition by rsgp41 or rsgpl60, was confirmed for the whole virus. Therefore, oral candidiasis in HIV-1-infected subjects may be augmented or may even be initiated by direct interaction between C. albicans and HIV-1 or HIV-1-infected cells. |
| doi_str_mv | 10.1086/514069 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_79154346</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>30106809</jstor_id><sourcerecordid>30106809</sourcerecordid><originalsourceid>FETCH-LOGICAL-c383t-6125209e8c558a6d7ca7bab1aa637ed866ea514f3c4465a3e538b50c8522c2213</originalsourceid><addsrcrecordid>eNqFkU1r3DAURUVpSCdJ-w8KopTs3OpJ1teyMW0TCBRKmq15luWgqS25kl2Yf58JGSbQTVd3cQ8HLpeQd8A-ATPqs4SaKfuKbEAKXSkF4jXZMMZ5BcbaN-SslC1jrBZKn5JTy4XWoDcEr9cJI72ZpjWm3g_BBR_djt6HvBZ6t5s9Bfow10CvQuwLXRJtMPahR4pjFxzGQv8GpE2a5tFPPi60EdUYfnv60z-EFMsFORlwLP7tIc_Jr29f75rr6vbH95vmy23lhBFLpYBLzqw3TkqDqtcOdYcdICqhfW-U8rjfOAhX10qi8FKYTjJnJOeOcxDn5PLZO-f0Z_VlaadQnB9HjD6tpdUWZC1q9V8QFBdcySfjh3_AbVpz3I9oORcWuGXyxeZyKiX7oZ1zmDDvWmDt0zPt8zN78P3BtnaT74_Y4Yp9__HQY3E4DhmjC-WIca2MrOWLZluWlI-1YMCUYVY8Ai5bmwA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>223912905</pqid></control><display><type>article</type><title>Human Immunodeficiency Virus Type 1 gp41 Binds to Candida albicans via Complement C3-like Regions</title><source>MEDLINE</source><source>Jstor Complete Legacy</source><source>Oxford University Press Journals All Titles (1996-Current)</source><creator>Würzner, Reinhard ; Gruber, Andreas ; Stoiber, Heribert ; Spruth, Martin ; Chen, Ying-Hua ; Lukasser-Vogl, Elisabeth ; Schwendinger, Michael G. ; Dierich, Manfred P.</creator><creatorcontrib>Würzner, Reinhard ; Gruber, Andreas ; Stoiber, Heribert ; Spruth, Martin ; Chen, Ying-Hua ; Lukasser-Vogl, Elisabeth ; Schwendinger, Michael G. ; Dierich, Manfred P.</creatorcontrib><description>Oral candidiasis in human immunodeficiency virus type 1 (HIV-1)-infected persons is believed to be caused by the acquired T lymphocyte immunodeficiency. The direct interaction of C. albicans and HIV-1 in vitro was investigated. Twice as many yeasts adhered to cells transfected with the HIV-1 env gene as they did to controls. HIV-1 rsgpl60 and rsgp41 but not rsgpl20 were found to bind to Candida albicans via two C3-like regions within gp41. Normal human serum, but not C3depleted serum, was able to inhibit rsgp41 binding to C. albicans. Vice versa, rsgpl60 and rsgp41 were able to block resetting of C. albicans with iC3b-coated sheep erythrocytes. Binding to C. albicans, and its inhibition by rsgp41 or rsgpl60, was confirmed for the whole virus. Therefore, oral candidiasis in HIV-1-infected subjects may be augmented or may even be initiated by direct interaction between C. albicans and HIV-1 or HIV-1-infected cells.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/514069</identifier><identifier>PMID: 9237717</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: University of Chicago Press</publisher><subject>AIDS ; AIDS/HIV ; Amino Acid Sequence ; Antibodies ; Binding, Competitive ; Biological and medical sciences ; Candida albicans ; Candida albicans - metabolism ; Complement C3 - genetics ; Complement C3 - metabolism ; Fundamental and applied biological sciences. Psychology ; HeLa Cells ; HIV ; HIV 1 ; HIV Core Protein p24 - analysis ; HIV Envelope Protein gp41 - genetics ; HIV Envelope Protein gp41 - metabolism ; HIV-1 - metabolism ; Humans ; Major Articles ; Microbiology ; Miscellaneous ; Molecular Sequence Data ; Monoclonal antibodies ; Mouth ; Recombinant Proteins ; Rosette formation ; Transfection ; Virology ; Viruses</subject><ispartof>The Journal of infectious diseases, 1997-08, Vol.176 (2), p.492-498</ispartof><rights>Copyright 1997 The University of Chicago</rights><rights>1997 INIST-CNRS</rights><rights>Copyright University of Chicago, acting through its Press Aug 1997</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c383t-6125209e8c558a6d7ca7bab1aa637ed866ea514f3c4465a3e538b50c8522c2213</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30106809$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30106809$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,778,782,801,27907,27908,58000,58233</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2768545$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9237717$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Würzner, Reinhard</creatorcontrib><creatorcontrib>Gruber, Andreas</creatorcontrib><creatorcontrib>Stoiber, Heribert</creatorcontrib><creatorcontrib>Spruth, Martin</creatorcontrib><creatorcontrib>Chen, Ying-Hua</creatorcontrib><creatorcontrib>Lukasser-Vogl, Elisabeth</creatorcontrib><creatorcontrib>Schwendinger, Michael G.</creatorcontrib><creatorcontrib>Dierich, Manfred P.</creatorcontrib><title>Human Immunodeficiency Virus Type 1 gp41 Binds to Candida albicans via Complement C3-like Regions</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>Oral candidiasis in human immunodeficiency virus type 1 (HIV-1)-infected persons is believed to be caused by the acquired T lymphocyte immunodeficiency. The direct interaction of C. albicans and HIV-1 in vitro was investigated. Twice as many yeasts adhered to cells transfected with the HIV-1 env gene as they did to controls. HIV-1 rsgpl60 and rsgp41 but not rsgpl20 were found to bind to Candida albicans via two C3-like regions within gp41. Normal human serum, but not C3depleted serum, was able to inhibit rsgp41 binding to C. albicans. Vice versa, rsgpl60 and rsgp41 were able to block resetting of C. albicans with iC3b-coated sheep erythrocytes. Binding to C. albicans, and its inhibition by rsgp41 or rsgpl60, was confirmed for the whole virus. Therefore, oral candidiasis in HIV-1-infected subjects may be augmented or may even be initiated by direct interaction between C. albicans and HIV-1 or HIV-1-infected cells.</description><subject>AIDS</subject><subject>AIDS/HIV</subject><subject>Amino Acid Sequence</subject><subject>Antibodies</subject><subject>Binding, Competitive</subject><subject>Biological and medical sciences</subject><subject>Candida albicans</subject><subject>Candida albicans - metabolism</subject><subject>Complement C3 - genetics</subject><subject>Complement C3 - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>HeLa Cells</subject><subject>HIV</subject><subject>HIV 1</subject><subject>HIV Core Protein p24 - analysis</subject><subject>HIV Envelope Protein gp41 - genetics</subject><subject>HIV Envelope Protein gp41 - metabolism</subject><subject>HIV-1 - metabolism</subject><subject>Humans</subject><subject>Major Articles</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Molecular Sequence Data</subject><subject>Monoclonal antibodies</subject><subject>Mouth</subject><subject>Recombinant Proteins</subject><subject>Rosette formation</subject><subject>Transfection</subject><subject>Virology</subject><subject>Viruses</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1r3DAURUVpSCdJ-w8KopTs3OpJ1teyMW0TCBRKmq15luWgqS25kl2Yf58JGSbQTVd3cQ8HLpeQd8A-ATPqs4SaKfuKbEAKXSkF4jXZMMZ5BcbaN-SslC1jrBZKn5JTy4XWoDcEr9cJI72ZpjWm3g_BBR_djt6HvBZ6t5s9Bfow10CvQuwLXRJtMPahR4pjFxzGQv8GpE2a5tFPPi60EdUYfnv60z-EFMsFORlwLP7tIc_Jr29f75rr6vbH95vmy23lhBFLpYBLzqw3TkqDqtcOdYcdICqhfW-U8rjfOAhX10qi8FKYTjJnJOeOcxDn5PLZO-f0Z_VlaadQnB9HjD6tpdUWZC1q9V8QFBdcySfjh3_AbVpz3I9oORcWuGXyxeZyKiX7oZ1zmDDvWmDt0zPt8zN78P3BtnaT74_Y4Yp9__HQY3E4DhmjC-WIca2MrOWLZluWlI-1YMCUYVY8Ai5bmwA</recordid><startdate>19970801</startdate><enddate>19970801</enddate><creator>Würzner, Reinhard</creator><creator>Gruber, Andreas</creator><creator>Stoiber, Heribert</creator><creator>Spruth, Martin</creator><creator>Chen, Ying-Hua</creator><creator>Lukasser-Vogl, Elisabeth</creator><creator>Schwendinger, Michael G.</creator><creator>Dierich, Manfred P.</creator><general>University of Chicago Press</general><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7U9</scope><scope>H94</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>19970801</creationdate><title>Human Immunodeficiency Virus Type 1 gp41 Binds to Candida albicans via Complement C3-like Regions</title><author>Würzner, Reinhard ; Gruber, Andreas ; Stoiber, Heribert ; Spruth, Martin ; Chen, Ying-Hua ; Lukasser-Vogl, Elisabeth ; Schwendinger, Michael G. ; Dierich, Manfred P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c383t-6125209e8c558a6d7ca7bab1aa637ed866ea514f3c4465a3e538b50c8522c2213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>AIDS</topic><topic>AIDS/HIV</topic><topic>Amino Acid Sequence</topic><topic>Antibodies</topic><topic>Binding, Competitive</topic><topic>Biological and medical sciences</topic><topic>Candida albicans</topic><topic>Candida albicans - metabolism</topic><topic>Complement C3 - genetics</topic><topic>Complement C3 - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>HeLa Cells</topic><topic>HIV</topic><topic>HIV 1</topic><topic>HIV Core Protein p24 - analysis</topic><topic>HIV Envelope Protein gp41 - genetics</topic><topic>HIV Envelope Protein gp41 - metabolism</topic><topic>HIV-1 - metabolism</topic><topic>Humans</topic><topic>Major Articles</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>Molecular Sequence Data</topic><topic>Monoclonal antibodies</topic><topic>Mouth</topic><topic>Recombinant Proteins</topic><topic>Rosette formation</topic><topic>Transfection</topic><topic>Virology</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Würzner, Reinhard</creatorcontrib><creatorcontrib>Gruber, Andreas</creatorcontrib><creatorcontrib>Stoiber, Heribert</creatorcontrib><creatorcontrib>Spruth, Martin</creatorcontrib><creatorcontrib>Chen, Ying-Hua</creatorcontrib><creatorcontrib>Lukasser-Vogl, Elisabeth</creatorcontrib><creatorcontrib>Schwendinger, Michael G.</creatorcontrib><creatorcontrib>Dierich, Manfred P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Würzner, Reinhard</au><au>Gruber, Andreas</au><au>Stoiber, Heribert</au><au>Spruth, Martin</au><au>Chen, Ying-Hua</au><au>Lukasser-Vogl, Elisabeth</au><au>Schwendinger, Michael G.</au><au>Dierich, Manfred P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human Immunodeficiency Virus Type 1 gp41 Binds to Candida albicans via Complement C3-like Regions</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>1997-08-01</date><risdate>1997</risdate><volume>176</volume><issue>2</issue><spage>492</spage><epage>498</epage><pages>492-498</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>Oral candidiasis in human immunodeficiency virus type 1 (HIV-1)-infected persons is believed to be caused by the acquired T lymphocyte immunodeficiency. The direct interaction of C. albicans and HIV-1 in vitro was investigated. Twice as many yeasts adhered to cells transfected with the HIV-1 env gene as they did to controls. HIV-1 rsgpl60 and rsgp41 but not rsgpl20 were found to bind to Candida albicans via two C3-like regions within gp41. Normal human serum, but not C3depleted serum, was able to inhibit rsgp41 binding to C. albicans. Vice versa, rsgpl60 and rsgp41 were able to block resetting of C. albicans with iC3b-coated sheep erythrocytes. Binding to C. albicans, and its inhibition by rsgp41 or rsgpl60, was confirmed for the whole virus. Therefore, oral candidiasis in HIV-1-infected subjects may be augmented or may even be initiated by direct interaction between C. albicans and HIV-1 or HIV-1-infected cells.</abstract><cop>Chicago, IL</cop><pub>University of Chicago Press</pub><pmid>9237717</pmid><doi>10.1086/514069</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-1899 |
| ispartof | The Journal of infectious diseases, 1997-08, Vol.176 (2), p.492-498 |
| issn | 0022-1899 1537-6613 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79154346 |
| source | MEDLINE; Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current) |
| subjects | AIDS AIDS/HIV Amino Acid Sequence Antibodies Binding, Competitive Biological and medical sciences Candida albicans Candida albicans - metabolism Complement C3 - genetics Complement C3 - metabolism Fundamental and applied biological sciences. Psychology HeLa Cells HIV HIV 1 HIV Core Protein p24 - analysis HIV Envelope Protein gp41 - genetics HIV Envelope Protein gp41 - metabolism HIV-1 - metabolism Humans Major Articles Microbiology Miscellaneous Molecular Sequence Data Monoclonal antibodies Mouth Recombinant Proteins Rosette formation Transfection Virology Viruses |
| title | Human Immunodeficiency Virus Type 1 gp41 Binds to Candida albicans via Complement C3-like Regions |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T00%3A45%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Human%20Immunodeficiency%20Virus%20Type%201%20gp41%20Binds%20to%20Candida%20albicans%20via%20Complement%20C3-like%20Regions&rft.jtitle=The%20Journal%20of%20infectious%20diseases&rft.au=W%C3%BCrzner,%20Reinhard&rft.date=1997-08-01&rft.volume=176&rft.issue=2&rft.spage=492&rft.epage=498&rft.pages=492-498&rft.issn=0022-1899&rft.eissn=1537-6613&rft.coden=JIDIAQ&rft_id=info:doi/10.1086/514069&rft_dat=%3Cjstor_proqu%3E30106809%3C/jstor_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=223912905&rft_id=info:pmid/9237717&rft_jstor_id=30106809&rfr_iscdi=true |