A rapid chromatographic method for quality control of technetium-99m-bicisate
The purpose of this work was to develop a simple and rapid method to determine the radiochemical purity of 99mTc-bicisate. A rapid paper chromatographic (PC) method was developed to determine the radiochemical purity of 99mTc-bicisate and compare the results with those of the manufacturer's rec...
Gespeichert in:
| Veröffentlicht in: | Journal of nuclear medicine technology 1997-03, Vol.25 (1), p.49-51 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 51 |
|---|---|
| container_issue | 1 |
| container_start_page | 49 |
| container_title | Journal of nuclear medicine technology |
| container_volume | 25 |
| creator | Amin, KC Saha, GB Go, RT |
| description | The purpose of this work was to develop a simple and rapid method to determine the radiochemical purity of 99mTc-bicisate.
A rapid paper chromatographic (PC) method was developed to determine the radiochemical purity of 99mTc-bicisate and compare the results with those of the manufacturer's recommended method. The present PC method included Whatman 3MM paper as the solid phase and ethyl acetate as the solvent.
The time for chromatography by this technique was 4-5 min compared to about 23 min by the manufacturer's method. The Rf value of 99mTc-bicisate (Rf = 0.9-1.0) was widely different from those of 99mTcO4- and reduced 99mTc (Rf = 0.0 for both) so the chromatographic strip after development could be readily cut into two segments, in order to determine the labeling yield.
No significant difference in labeling yields was found between the present method and the manufacturer's method. The PC method using Whatman 3MM paper and ethyl acetate is a simple and fast technique to determine the radiochemical purity of 99mTc-bicisate and may be substituted for the manufacturer's recommended method to save time. |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_79153925</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>79153925</sourcerecordid><originalsourceid>FETCH-LOGICAL-h152t-e3e5c9072355b221c6aca5b6ffe7912013b3838e6d6e4de80420b920733c240f3</originalsourceid><addsrcrecordid>eNpFj8tKAzEYRoMotVYfQcjK3UAuk8xkWYo3qLjRdchk_mkik0mbZJC-vRULrj4-OBw4F2hJBReVkLK5REtCJa2EIOIa3eT8RQiRbdsu0EIxriSpl-htjZPZ-x5bl2IwJe5O13mLAxQXezzEhA-zGX05YhunkuKI44ALWDdB8XOolApV563PpsAtuhrMmOHuvCv0-fT4sXmptu_Pr5v1tnJUsFIBB2EVaRgXomOMWmmsEZ0cBmgUZYTyjre8BdlLqHtoSc1IpxhpOLesJgNfoYc_7z7Fwwy56OCzhXE0E8Q565NFcMXECbw_g3MXoNf75INJR33u_xc5v3PfPoGeZjuCSb_wbyQTmupa8R8epGTd</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>79153925</pqid></control><display><type>article</type><title>A rapid chromatographic method for quality control of technetium-99m-bicisate</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Amin, KC ; Saha, GB ; Go, RT</creator><creatorcontrib>Amin, KC ; Saha, GB ; Go, RT</creatorcontrib><description>The purpose of this work was to develop a simple and rapid method to determine the radiochemical purity of 99mTc-bicisate.
A rapid paper chromatographic (PC) method was developed to determine the radiochemical purity of 99mTc-bicisate and compare the results with those of the manufacturer's recommended method. The present PC method included Whatman 3MM paper as the solid phase and ethyl acetate as the solvent.
The time for chromatography by this technique was 4-5 min compared to about 23 min by the manufacturer's method. The Rf value of 99mTc-bicisate (Rf = 0.9-1.0) was widely different from those of 99mTcO4- and reduced 99mTc (Rf = 0.0 for both) so the chromatographic strip after development could be readily cut into two segments, in order to determine the labeling yield.
No significant difference in labeling yields was found between the present method and the manufacturer's method. The PC method using Whatman 3MM paper and ethyl acetate is a simple and fast technique to determine the radiochemical purity of 99mTc-bicisate and may be substituted for the manufacturer's recommended method to save time.</description><identifier>ISSN: 0161-5505</identifier><identifier>ISSN: 0091-4916</identifier><identifier>EISSN: 1535-5667</identifier><identifier>PMID: 9239604</identifier><language>eng</language><publisher>United States: Soc Nuclear Med</publisher><subject>Acetates - chemistry ; Chromatography, Paper ; Cysteine - analogs & derivatives ; Cysteine - isolation & purification ; Organotechnetium Compounds - analysis ; Organotechnetium Compounds - isolation & purification ; Oxides - analysis ; Quality Control ; Radiochemistry ; Radiopharmaceuticals - analysis ; Radiopharmaceuticals - isolation & purification ; Sodium Pertechnetate Tc 99m - analysis ; Sodium Pertechnetate Tc 99m - chemistry ; Solvents - chemistry ; Technetium - analysis ; Technetium - chemistry ; Technetium Compounds - analysis ; Time Factors</subject><ispartof>Journal of nuclear medicine technology, 1997-03, Vol.25 (1), p.49-51</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9239604$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Amin, KC</creatorcontrib><creatorcontrib>Saha, GB</creatorcontrib><creatorcontrib>Go, RT</creatorcontrib><title>A rapid chromatographic method for quality control of technetium-99m-bicisate</title><title>Journal of nuclear medicine technology</title><addtitle>J Nucl Med Technol</addtitle><description>The purpose of this work was to develop a simple and rapid method to determine the radiochemical purity of 99mTc-bicisate.
A rapid paper chromatographic (PC) method was developed to determine the radiochemical purity of 99mTc-bicisate and compare the results with those of the manufacturer's recommended method. The present PC method included Whatman 3MM paper as the solid phase and ethyl acetate as the solvent.
The time for chromatography by this technique was 4-5 min compared to about 23 min by the manufacturer's method. The Rf value of 99mTc-bicisate (Rf = 0.9-1.0) was widely different from those of 99mTcO4- and reduced 99mTc (Rf = 0.0 for both) so the chromatographic strip after development could be readily cut into two segments, in order to determine the labeling yield.
No significant difference in labeling yields was found between the present method and the manufacturer's method. The PC method using Whatman 3MM paper and ethyl acetate is a simple and fast technique to determine the radiochemical purity of 99mTc-bicisate and may be substituted for the manufacturer's recommended method to save time.</description><subject>Acetates - chemistry</subject><subject>Chromatography, Paper</subject><subject>Cysteine - analogs & derivatives</subject><subject>Cysteine - isolation & purification</subject><subject>Organotechnetium Compounds - analysis</subject><subject>Organotechnetium Compounds - isolation & purification</subject><subject>Oxides - analysis</subject><subject>Quality Control</subject><subject>Radiochemistry</subject><subject>Radiopharmaceuticals - analysis</subject><subject>Radiopharmaceuticals - isolation & purification</subject><subject>Sodium Pertechnetate Tc 99m - analysis</subject><subject>Sodium Pertechnetate Tc 99m - chemistry</subject><subject>Solvents - chemistry</subject><subject>Technetium - analysis</subject><subject>Technetium - chemistry</subject><subject>Technetium Compounds - analysis</subject><subject>Time Factors</subject><issn>0161-5505</issn><issn>0091-4916</issn><issn>1535-5667</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFj8tKAzEYRoMotVYfQcjK3UAuk8xkWYo3qLjRdchk_mkik0mbZJC-vRULrj4-OBw4F2hJBReVkLK5REtCJa2EIOIa3eT8RQiRbdsu0EIxriSpl-htjZPZ-x5bl2IwJe5O13mLAxQXezzEhA-zGX05YhunkuKI44ALWDdB8XOolApV563PpsAtuhrMmOHuvCv0-fT4sXmptu_Pr5v1tnJUsFIBB2EVaRgXomOMWmmsEZ0cBmgUZYTyjre8BdlLqHtoSc1IpxhpOLesJgNfoYc_7z7Fwwy56OCzhXE0E8Q565NFcMXECbw_g3MXoNf75INJR33u_xc5v3PfPoGeZjuCSb_wbyQTmupa8R8epGTd</recordid><startdate>199703</startdate><enddate>199703</enddate><creator>Amin, KC</creator><creator>Saha, GB</creator><creator>Go, RT</creator><general>Soc Nuclear Med</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>199703</creationdate><title>A rapid chromatographic method for quality control of technetium-99m-bicisate</title><author>Amin, KC ; Saha, GB ; Go, RT</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h152t-e3e5c9072355b221c6aca5b6ffe7912013b3838e6d6e4de80420b920733c240f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Acetates - chemistry</topic><topic>Chromatography, Paper</topic><topic>Cysteine - analogs & derivatives</topic><topic>Cysteine - isolation & purification</topic><topic>Organotechnetium Compounds - analysis</topic><topic>Organotechnetium Compounds - isolation & purification</topic><topic>Oxides - analysis</topic><topic>Quality Control</topic><topic>Radiochemistry</topic><topic>Radiopharmaceuticals - analysis</topic><topic>Radiopharmaceuticals - isolation & purification</topic><topic>Sodium Pertechnetate Tc 99m - analysis</topic><topic>Sodium Pertechnetate Tc 99m - chemistry</topic><topic>Solvents - chemistry</topic><topic>Technetium - analysis</topic><topic>Technetium - chemistry</topic><topic>Technetium Compounds - analysis</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Amin, KC</creatorcontrib><creatorcontrib>Saha, GB</creatorcontrib><creatorcontrib>Go, RT</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of nuclear medicine technology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Amin, KC</au><au>Saha, GB</au><au>Go, RT</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A rapid chromatographic method for quality control of technetium-99m-bicisate</atitle><jtitle>Journal of nuclear medicine technology</jtitle><addtitle>J Nucl Med Technol</addtitle><date>1997-03</date><risdate>1997</risdate><volume>25</volume><issue>1</issue><spage>49</spage><epage>51</epage><pages>49-51</pages><issn>0161-5505</issn><issn>0091-4916</issn><eissn>1535-5667</eissn><abstract>The purpose of this work was to develop a simple and rapid method to determine the radiochemical purity of 99mTc-bicisate.
A rapid paper chromatographic (PC) method was developed to determine the radiochemical purity of 99mTc-bicisate and compare the results with those of the manufacturer's recommended method. The present PC method included Whatman 3MM paper as the solid phase and ethyl acetate as the solvent.
The time for chromatography by this technique was 4-5 min compared to about 23 min by the manufacturer's method. The Rf value of 99mTc-bicisate (Rf = 0.9-1.0) was widely different from those of 99mTcO4- and reduced 99mTc (Rf = 0.0 for both) so the chromatographic strip after development could be readily cut into two segments, in order to determine the labeling yield.
No significant difference in labeling yields was found between the present method and the manufacturer's method. The PC method using Whatman 3MM paper and ethyl acetate is a simple and fast technique to determine the radiochemical purity of 99mTc-bicisate and may be substituted for the manufacturer's recommended method to save time.</abstract><cop>United States</cop><pub>Soc Nuclear Med</pub><pmid>9239604</pmid><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0161-5505 |
| ispartof | Journal of nuclear medicine technology, 1997-03, Vol.25 (1), p.49-51 |
| issn | 0161-5505 0091-4916 1535-5667 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79153925 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Acetates - chemistry Chromatography, Paper Cysteine - analogs & derivatives Cysteine - isolation & purification Organotechnetium Compounds - analysis Organotechnetium Compounds - isolation & purification Oxides - analysis Quality Control Radiochemistry Radiopharmaceuticals - analysis Radiopharmaceuticals - isolation & purification Sodium Pertechnetate Tc 99m - analysis Sodium Pertechnetate Tc 99m - chemistry Solvents - chemistry Technetium - analysis Technetium - chemistry Technetium Compounds - analysis Time Factors |
| title | A rapid chromatographic method for quality control of technetium-99m-bicisate |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T04%3A44%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20rapid%20chromatographic%20method%20for%20quality%20control%20of%20technetium-99m-bicisate&rft.jtitle=Journal%20of%20nuclear%20medicine%20technology&rft.au=Amin,%20KC&rft.date=1997-03&rft.volume=25&rft.issue=1&rft.spage=49&rft.epage=51&rft.pages=49-51&rft.issn=0161-5505&rft.eissn=1535-5667&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E79153925%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=79153925&rft_id=info:pmid/9239604&rfr_iscdi=true |