Oral erythromycin improves gastrointestinal motility and transit after subtotal but not total gastrectomy for cancer
Background Erythromycin has been shown to be a powerful prokinetic of the gastrointestinal tract. Little is known about its value to improve motility and transit in gastrectomized patients. Methods Thirteen disease‐free patients subjected to subtotal gastrectomy and 11 subjected to total gastrectomy...
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| Veröffentlicht in: | British journal of surgery 1997-07, Vol.84 (7), p.1017-1021 |
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| container_title | British journal of surgery |
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| creator | Altomare, D. F. Rubini, D. Pilot, M.-A. Farese, S. Rubini, G. Rinaldi, M. Memeo, V. D'Addabbo, A. |
| description | Background Erythromycin has been shown to be a powerful prokinetic of the gastrointestinal tract. Little is known about its value to improve motility and transit in gastrectomized patients.
Methods Thirteen disease‐free patients subjected to subtotal gastrectomy and 11 subjected to total gastrectomy for gastric cancer entered the study. Gastrointestinal transit of a standard 99mTc‐labelled meal and fasting motility were studied before and after oral erythromycin.
Results In patients who had subtotal gastrectomy mean(s.d.) gastric half‐emptying time was 42(14) min before and 26(11) min after erythromycin (P = 0·011). Before erythromycin prolonged rhythmical contractions (3 per min) were recorded in eight patients, sporadic non‐organized contractions in two and prolonged bursts of waves in one. After erythromycin, clustered waves resembling a migrating motor complex (MMC) appeared in eight patients, while rhythmic motor activity was unchanged in three. In patients who had total gastrectomy jejunal half‐emptying time was 39(18) min before and 45(12) min after erythromycin. In eight patients, frequent MMCs were recorded, peristaltic in four, synchronous in one, antiperistaltic in two, with clusters of non‐propagated waves in one. After erythromycin, longer peristaltic MMCs were recorded in three, antiperistaltic MMCs persisted in two, synchronous in one and clusters of non‐propagated waves in two.
Conclusion Oral erythromycin improves gastrointestinal transit and motility after subtotal gastrectomy. The findings after total gastrectomy are controversial. |
| doi_str_mv | 10.1002/bjs.1800840735 |
| format | Article |
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Methods Thirteen disease‐free patients subjected to subtotal gastrectomy and 11 subjected to total gastrectomy for gastric cancer entered the study. Gastrointestinal transit of a standard 99mTc‐labelled meal and fasting motility were studied before and after oral erythromycin.
Results In patients who had subtotal gastrectomy mean(s.d.) gastric half‐emptying time was 42(14) min before and 26(11) min after erythromycin (P = 0·011). Before erythromycin prolonged rhythmical contractions (3 per min) were recorded in eight patients, sporadic non‐organized contractions in two and prolonged bursts of waves in one. After erythromycin, clustered waves resembling a migrating motor complex (MMC) appeared in eight patients, while rhythmic motor activity was unchanged in three. In patients who had total gastrectomy jejunal half‐emptying time was 39(18) min before and 45(12) min after erythromycin. In eight patients, frequent MMCs were recorded, peristaltic in four, synchronous in one, antiperistaltic in two, with clusters of non‐propagated waves in one. After erythromycin, longer peristaltic MMCs were recorded in three, antiperistaltic MMCs persisted in two, synchronous in one and clusters of non‐propagated waves in two.
Conclusion Oral erythromycin improves gastrointestinal transit and motility after subtotal gastrectomy. The findings after total gastrectomy are controversial.</description><identifier>ISSN: 0007-1323</identifier><identifier>EISSN: 1365-2168</identifier><identifier>DOI: 10.1002/bjs.1800840735</identifier><identifier>PMID: 9240156</identifier><identifier>CODEN: BJSUAM</identifier><language>eng</language><publisher>Bristol: John Wiley & Sons, Ltd</publisher><subject>Administration, Oral ; Adult ; Aged ; Biological and medical sciences ; Digestive system ; Erythromycin - administration & dosage ; Erythromycin - pharmacology ; Female ; Gastrectomy - methods ; Gastrointestinal Agents - administration & dosage ; Gastrointestinal Agents - pharmacology ; Gastrointestinal Motility - drug effects ; Gastrointestinal Transit - drug effects ; Humans ; Male ; Manometry ; Medical sciences ; Middle Aged ; Pharmacology. Drug treatments ; Postoperative Period ; Stomach Neoplasms - physiopathology ; Stomach Neoplasms - surgery</subject><ispartof>British journal of surgery, 1997-07, Vol.84 (7), p.1017-1021</ispartof><rights>Copyright © 1997 British Journal of Surgery Society Ltd.</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3975-e192d756926933d3967a978904d46e82fa2251283f12bad92aeab0d9313b5c63</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fbjs.1800840735$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fbjs.1800840735$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2714565$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9240156$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Altomare, D. F.</creatorcontrib><creatorcontrib>Rubini, D.</creatorcontrib><creatorcontrib>Pilot, M.-A.</creatorcontrib><creatorcontrib>Farese, S.</creatorcontrib><creatorcontrib>Rubini, G.</creatorcontrib><creatorcontrib>Rinaldi, M.</creatorcontrib><creatorcontrib>Memeo, V.</creatorcontrib><creatorcontrib>D'Addabbo, A.</creatorcontrib><title>Oral erythromycin improves gastrointestinal motility and transit after subtotal but not total gastrectomy for cancer</title><title>British journal of surgery</title><addtitle>Br J Surg</addtitle><description>Background Erythromycin has been shown to be a powerful prokinetic of the gastrointestinal tract. Little is known about its value to improve motility and transit in gastrectomized patients.
Methods Thirteen disease‐free patients subjected to subtotal gastrectomy and 11 subjected to total gastrectomy for gastric cancer entered the study. Gastrointestinal transit of a standard 99mTc‐labelled meal and fasting motility were studied before and after oral erythromycin.
Results In patients who had subtotal gastrectomy mean(s.d.) gastric half‐emptying time was 42(14) min before and 26(11) min after erythromycin (P = 0·011). Before erythromycin prolonged rhythmical contractions (3 per min) were recorded in eight patients, sporadic non‐organized contractions in two and prolonged bursts of waves in one. After erythromycin, clustered waves resembling a migrating motor complex (MMC) appeared in eight patients, while rhythmic motor activity was unchanged in three. In patients who had total gastrectomy jejunal half‐emptying time was 39(18) min before and 45(12) min after erythromycin. In eight patients, frequent MMCs were recorded, peristaltic in four, synchronous in one, antiperistaltic in two, with clusters of non‐propagated waves in one. After erythromycin, longer peristaltic MMCs were recorded in three, antiperistaltic MMCs persisted in two, synchronous in one and clusters of non‐propagated waves in two.
Conclusion Oral erythromycin improves gastrointestinal transit and motility after subtotal gastrectomy. The findings after total gastrectomy are controversial.</description><subject>Administration, Oral</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Digestive system</subject><subject>Erythromycin - administration & dosage</subject><subject>Erythromycin - pharmacology</subject><subject>Female</subject><subject>Gastrectomy - methods</subject><subject>Gastrointestinal Agents - administration & dosage</subject><subject>Gastrointestinal Agents - pharmacology</subject><subject>Gastrointestinal Motility - drug effects</subject><subject>Gastrointestinal Transit - drug effects</subject><subject>Humans</subject><subject>Male</subject><subject>Manometry</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Postoperative Period</subject><subject>Stomach Neoplasms - physiopathology</subject><subject>Stomach Neoplasms - surgery</subject><issn>0007-1323</issn><issn>1365-2168</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkctPFTEYxRujwQu4ZWfShXE32Mf0tVSiILlXEiVx2XzT6WBxHth2gPnvKd6by6r5cn7nJKcHoRNKTikh7FNzm06pJkTXRHHxCq0ol6JiVOrXaEUIURXljL9FhyndEkI5EewAHRhWEyrkCuWrCD32ccl_4jQsLow4DHdxuvcJ30DKcQpj9imHsWDDlEMf8oJhbHGOMKaQMXTZR5zmJk-5MM2c8ThlvL3-R3iXSzTupogdjM7HY_Smgz75d7v3CF1_-3p9dlGtr86_n31eV44bJSpPDWuVkIZJw3nLjVRglDakbmvpNeuAMUGZ5h1lDbSGgYeGtIZT3ggn-RH6uI0tff7NpYQdQnK-72H005ysMlRwpXUB3-_AuRl8a-9iGCAudvdLRf-w0yE56LvS3IW0x5iitZCiYGaLPYTeL3uZEvu8lC1L2Zel7JfLXy9X8VZbb0jZP-69EP9aqbgS9vePc_tzs9nU6lLbNX8CoU2YJA</recordid><startdate>199707</startdate><enddate>199707</enddate><creator>Altomare, D. F.</creator><creator>Rubini, D.</creator><creator>Pilot, M.-A.</creator><creator>Farese, S.</creator><creator>Rubini, G.</creator><creator>Rinaldi, M.</creator><creator>Memeo, V.</creator><creator>D'Addabbo, A.</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>199707</creationdate><title>Oral erythromycin improves gastrointestinal motility and transit after subtotal but not total gastrectomy for cancer</title><author>Altomare, D. F. ; Rubini, D. ; Pilot, M.-A. ; Farese, S. ; Rubini, G. ; Rinaldi, M. ; Memeo, V. ; D'Addabbo, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3975-e192d756926933d3967a978904d46e82fa2251283f12bad92aeab0d9313b5c63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Administration, Oral</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Digestive system</topic><topic>Erythromycin - administration & dosage</topic><topic>Erythromycin - pharmacology</topic><topic>Female</topic><topic>Gastrectomy - methods</topic><topic>Gastrointestinal Agents - administration & dosage</topic><topic>Gastrointestinal Agents - pharmacology</topic><topic>Gastrointestinal Motility - drug effects</topic><topic>Gastrointestinal Transit - drug effects</topic><topic>Humans</topic><topic>Male</topic><topic>Manometry</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Postoperative Period</topic><topic>Stomach Neoplasms - physiopathology</topic><topic>Stomach Neoplasms - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Altomare, D. F.</creatorcontrib><creatorcontrib>Rubini, D.</creatorcontrib><creatorcontrib>Pilot, M.-A.</creatorcontrib><creatorcontrib>Farese, S.</creatorcontrib><creatorcontrib>Rubini, G.</creatorcontrib><creatorcontrib>Rinaldi, M.</creatorcontrib><creatorcontrib>Memeo, V.</creatorcontrib><creatorcontrib>D'Addabbo, A.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Altomare, D. F.</au><au>Rubini, D.</au><au>Pilot, M.-A.</au><au>Farese, S.</au><au>Rubini, G.</au><au>Rinaldi, M.</au><au>Memeo, V.</au><au>D'Addabbo, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oral erythromycin improves gastrointestinal motility and transit after subtotal but not total gastrectomy for cancer</atitle><jtitle>British journal of surgery</jtitle><addtitle>Br J Surg</addtitle><date>1997-07</date><risdate>1997</risdate><volume>84</volume><issue>7</issue><spage>1017</spage><epage>1021</epage><pages>1017-1021</pages><issn>0007-1323</issn><eissn>1365-2168</eissn><coden>BJSUAM</coden><abstract>Background Erythromycin has been shown to be a powerful prokinetic of the gastrointestinal tract. Little is known about its value to improve motility and transit in gastrectomized patients.
Methods Thirteen disease‐free patients subjected to subtotal gastrectomy and 11 subjected to total gastrectomy for gastric cancer entered the study. Gastrointestinal transit of a standard 99mTc‐labelled meal and fasting motility were studied before and after oral erythromycin.
Results In patients who had subtotal gastrectomy mean(s.d.) gastric half‐emptying time was 42(14) min before and 26(11) min after erythromycin (P = 0·011). Before erythromycin prolonged rhythmical contractions (3 per min) were recorded in eight patients, sporadic non‐organized contractions in two and prolonged bursts of waves in one. After erythromycin, clustered waves resembling a migrating motor complex (MMC) appeared in eight patients, while rhythmic motor activity was unchanged in three. In patients who had total gastrectomy jejunal half‐emptying time was 39(18) min before and 45(12) min after erythromycin. In eight patients, frequent MMCs were recorded, peristaltic in four, synchronous in one, antiperistaltic in two, with clusters of non‐propagated waves in one. After erythromycin, longer peristaltic MMCs were recorded in three, antiperistaltic MMCs persisted in two, synchronous in one and clusters of non‐propagated waves in two.
Conclusion Oral erythromycin improves gastrointestinal transit and motility after subtotal gastrectomy. The findings after total gastrectomy are controversial.</abstract><cop>Bristol</cop><pub>John Wiley & Sons, Ltd</pub><pmid>9240156</pmid><doi>10.1002/bjs.1800840735</doi><tpages>5</tpages></addata></record> |
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| ispartof | British journal of surgery, 1997-07, Vol.84 (7), p.1017-1021 |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Wiley Online Library All Journals |
| subjects | Administration, Oral Adult Aged Biological and medical sciences Digestive system Erythromycin - administration & dosage Erythromycin - pharmacology Female Gastrectomy - methods Gastrointestinal Agents - administration & dosage Gastrointestinal Agents - pharmacology Gastrointestinal Motility - drug effects Gastrointestinal Transit - drug effects Humans Male Manometry Medical sciences Middle Aged Pharmacology. Drug treatments Postoperative Period Stomach Neoplasms - physiopathology Stomach Neoplasms - surgery |
| title | Oral erythromycin improves gastrointestinal motility and transit after subtotal but not total gastrectomy for cancer |
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