Direct action of nitric oxide on osteoblastic differentiation
The effect of nitric oxide (NO) on osteoblastic differentiation was examined in cultured mouse osteoblasts. Interleukin-1β and tumor necrosis factor-α expressed inducible NO synthase gene with little effect on constitutive NO synthase gene. These cytokines increased NO production, which was inhibite...
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| Veröffentlicht in: | FEBS letters 1997-06, Vol.410 (2), p.238-242 |
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| creator | Hikiji, Hisako Shin, Wee Soo Oida, Shinichiro Takato, Tuyoshi Koizumi, Toshiyuki Toyo-oka, Teruhiko |
| description | The effect of nitric oxide (NO) on osteoblastic differentiation was examined in cultured mouse osteoblasts. Interleukin-1β and tumor necrosis factor-α expressed inducible NO synthase gene with little effect on constitutive NO synthase gene. These cytokines increased NO production, which was inhibited by
l-NMMA pretreatment, and decreased alkaline phosphatase (AIPase) activity, which was not restored by
l-NMMA. Furthermore, NO donors, sodium nitroprusside and NONOate dose-dependently elevated AIPase activity and expression of osteocalcin gene. These results suggest that NO directly facilitates osteoblastic differentiation and the cytokine-induced inhibition of AIPase activity is mediated via mechanism other than NO. |
| doi_str_mv | 10.1016/S0014-5793(97)00597-8 |
| format | Article |
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l-NMMA pretreatment, and decreased alkaline phosphatase (AIPase) activity, which was not restored by
l-NMMA. Furthermore, NO donors, sodium nitroprusside and NONOate dose-dependently elevated AIPase activity and expression of osteocalcin gene. These results suggest that NO directly facilitates osteoblastic differentiation and the cytokine-induced inhibition of AIPase activity is mediated via mechanism other than NO.</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1016/S0014-5793(97)00597-8</identifier><identifier>PMID: 9237637</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>AIPase ; alkaline phosphatase ; Alkaline Phosphatase - biosynthesis ; Animals ; Cell Differentiation - drug effects ; Cells, Cultured ; cGMP ; Cyclic GMP - biosynthesis ; cyclic guanosine monophosphate ; diethylamine NONOate ; Dinoprostone - biosynthesis ; EIA ; enzyme immunoassay ; Ethanamine, N-ethyl-, compound with 1,1-diethyl-2-hydroxy-2-nitrosohydrazine ; Hydrazines - pharmacology ; IL-1β ; Interleukin-1 - pharmacology ; Interleukin-1β ; l-NMMA ; Mice ; NG-monomethyl-l-arginine ; nitric oxide ; Nitric Oxide - pharmacology ; nitric oxide synthase ; Nitric Oxide Synthase - genetics ; Nitrogen Oxides ; Nitroprusside - pharmacology ; NOS ; NOS gene expression ; Osteoblastic differentiation ; Osteoblasts - cytology ; Osteoblasts - drug effects ; Osteocalcin - genetics ; PGE2 ; prostaglandin E2 ; reverse transcription-polymerase chain reaction ; RNA, Messenger ; RT-PCR ; SNP ; sodium nitroprusside ; TNF-α ; Tumor Necrosis Factor-alpha - pharmacology ; tumor necrosis factor-α</subject><ispartof>FEBS letters, 1997-06, Vol.410 (2), p.238-242</ispartof><rights>1997 Federation of European Biochemical Societies</rights><rights>FEBS Letters 410 (1997) 1873-3468 © 2015 Federation of European Biochemical Societies</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4918-23f09ec427e963f05f6a2fe318dba4b011874d47ee3caf538c6fdb9f20719223</citedby><cites>FETCH-LOGICAL-c4918-23f09ec427e963f05f6a2fe318dba4b011874d47ee3caf538c6fdb9f20719223</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1016%2FS0014-5793%2897%2900597-8$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0014579397005978$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,1411,1427,3537,27901,27902,45550,45551,46384,46808,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9237637$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hikiji, Hisako</creatorcontrib><creatorcontrib>Shin, Wee Soo</creatorcontrib><creatorcontrib>Oida, Shinichiro</creatorcontrib><creatorcontrib>Takato, Tuyoshi</creatorcontrib><creatorcontrib>Koizumi, Toshiyuki</creatorcontrib><creatorcontrib>Toyo-oka, Teruhiko</creatorcontrib><title>Direct action of nitric oxide on osteoblastic differentiation</title><title>FEBS letters</title><addtitle>FEBS Lett</addtitle><description>The effect of nitric oxide (NO) on osteoblastic differentiation was examined in cultured mouse osteoblasts. Interleukin-1β and tumor necrosis factor-α expressed inducible NO synthase gene with little effect on constitutive NO synthase gene. These cytokines increased NO production, which was inhibited by
l-NMMA pretreatment, and decreased alkaline phosphatase (AIPase) activity, which was not restored by
l-NMMA. Furthermore, NO donors, sodium nitroprusside and NONOate dose-dependently elevated AIPase activity and expression of osteocalcin gene. These results suggest that NO directly facilitates osteoblastic differentiation and the cytokine-induced inhibition of AIPase activity is mediated via mechanism other than NO.</description><subject>AIPase</subject><subject>alkaline phosphatase</subject><subject>Alkaline Phosphatase - biosynthesis</subject><subject>Animals</subject><subject>Cell Differentiation - drug effects</subject><subject>Cells, Cultured</subject><subject>cGMP</subject><subject>Cyclic GMP - biosynthesis</subject><subject>cyclic guanosine monophosphate</subject><subject>diethylamine NONOate</subject><subject>Dinoprostone - biosynthesis</subject><subject>EIA</subject><subject>enzyme immunoassay</subject><subject>Ethanamine, N-ethyl-, compound with 1,1-diethyl-2-hydroxy-2-nitrosohydrazine</subject><subject>Hydrazines - pharmacology</subject><subject>IL-1β</subject><subject>Interleukin-1 - pharmacology</subject><subject>Interleukin-1β</subject><subject>l-NMMA</subject><subject>Mice</subject><subject>NG-monomethyl-l-arginine</subject><subject>nitric oxide</subject><subject>Nitric Oxide - pharmacology</subject><subject>nitric oxide synthase</subject><subject>Nitric Oxide Synthase - genetics</subject><subject>Nitrogen Oxides</subject><subject>Nitroprusside - pharmacology</subject><subject>NOS</subject><subject>NOS gene expression</subject><subject>Osteoblastic differentiation</subject><subject>Osteoblasts - cytology</subject><subject>Osteoblasts - drug effects</subject><subject>Osteocalcin - genetics</subject><subject>PGE2</subject><subject>prostaglandin E2</subject><subject>reverse transcription-polymerase chain reaction</subject><subject>RNA, Messenger</subject><subject>RT-PCR</subject><subject>SNP</subject><subject>sodium nitroprusside</subject><subject>TNF-α</subject><subject>Tumor Necrosis Factor-alpha - pharmacology</subject><subject>tumor necrosis factor-α</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUctOwzAQtBColMcnVMoJwSHgRxLHB4SgtBSpEgd6txxnLRmlSbFToH-Pk1S9wsGyd2Z2djVGaELwLcEku3vHmCRxygW7FvwG41TwOD9CY5JzFrMky4_R-CA5RWfef-BQ50SM0EhQxjPGx-j-2TrQbaR0a5s6akxU29ZZHTU_toSog3wLTVEp3wa0tMaAg7q1qtNfoBOjKg-X-_screaz1XQRL99eXqePy1gnguQxZQYL0AnlILLwTk2mqAFG8rJQSYFJ2DkpEw7AtDIpy3VmykIYijkRlLJzdDXYblzzuQXfyrX1GqpK1dBsveSCpDScIEwHoXaN9w6M3Di7Vm4nCZZdarJPTXaRSMFln5rMQ99kP2BbrKE8dO1jCvxi4L9tBbv_mcr57In2TEcI3sPdqIfBCkJeXxac9NpCraHsP0KWjf1j2V89P5Ae</recordid><startdate>19970630</startdate><enddate>19970630</enddate><creator>Hikiji, Hisako</creator><creator>Shin, Wee Soo</creator><creator>Oida, Shinichiro</creator><creator>Takato, Tuyoshi</creator><creator>Koizumi, Toshiyuki</creator><creator>Toyo-oka, Teruhiko</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19970630</creationdate><title>Direct action of nitric oxide on osteoblastic differentiation</title><author>Hikiji, Hisako ; Shin, Wee Soo ; Oida, Shinichiro ; Takato, Tuyoshi ; Koizumi, Toshiyuki ; Toyo-oka, Teruhiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4918-23f09ec427e963f05f6a2fe318dba4b011874d47ee3caf538c6fdb9f20719223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>AIPase</topic><topic>alkaline phosphatase</topic><topic>Alkaline Phosphatase - biosynthesis</topic><topic>Animals</topic><topic>Cell Differentiation - drug effects</topic><topic>Cells, Cultured</topic><topic>cGMP</topic><topic>Cyclic GMP - biosynthesis</topic><topic>cyclic guanosine monophosphate</topic><topic>diethylamine NONOate</topic><topic>Dinoprostone - biosynthesis</topic><topic>EIA</topic><topic>enzyme immunoassay</topic><topic>Ethanamine, N-ethyl-, compound with 1,1-diethyl-2-hydroxy-2-nitrosohydrazine</topic><topic>Hydrazines - pharmacology</topic><topic>IL-1β</topic><topic>Interleukin-1 - pharmacology</topic><topic>Interleukin-1β</topic><topic>l-NMMA</topic><topic>Mice</topic><topic>NG-monomethyl-l-arginine</topic><topic>nitric oxide</topic><topic>Nitric Oxide - pharmacology</topic><topic>nitric oxide synthase</topic><topic>Nitric Oxide Synthase - genetics</topic><topic>Nitrogen Oxides</topic><topic>Nitroprusside - pharmacology</topic><topic>NOS</topic><topic>NOS gene expression</topic><topic>Osteoblastic differentiation</topic><topic>Osteoblasts - cytology</topic><topic>Osteoblasts - drug effects</topic><topic>Osteocalcin - genetics</topic><topic>PGE2</topic><topic>prostaglandin E2</topic><topic>reverse transcription-polymerase chain reaction</topic><topic>RNA, Messenger</topic><topic>RT-PCR</topic><topic>SNP</topic><topic>sodium nitroprusside</topic><topic>TNF-α</topic><topic>Tumor Necrosis Factor-alpha - pharmacology</topic><topic>tumor necrosis factor-α</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hikiji, Hisako</creatorcontrib><creatorcontrib>Shin, Wee Soo</creatorcontrib><creatorcontrib>Oida, Shinichiro</creatorcontrib><creatorcontrib>Takato, Tuyoshi</creatorcontrib><creatorcontrib>Koizumi, Toshiyuki</creatorcontrib><creatorcontrib>Toyo-oka, Teruhiko</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hikiji, Hisako</au><au>Shin, Wee Soo</au><au>Oida, Shinichiro</au><au>Takato, Tuyoshi</au><au>Koizumi, Toshiyuki</au><au>Toyo-oka, Teruhiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Direct action of nitric oxide on osteoblastic differentiation</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>1997-06-30</date><risdate>1997</risdate><volume>410</volume><issue>2</issue><spage>238</spage><epage>242</epage><pages>238-242</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><abstract>The effect of nitric oxide (NO) on osteoblastic differentiation was examined in cultured mouse osteoblasts. Interleukin-1β and tumor necrosis factor-α expressed inducible NO synthase gene with little effect on constitutive NO synthase gene. These cytokines increased NO production, which was inhibited by
l-NMMA pretreatment, and decreased alkaline phosphatase (AIPase) activity, which was not restored by
l-NMMA. Furthermore, NO donors, sodium nitroprusside and NONOate dose-dependently elevated AIPase activity and expression of osteocalcin gene. These results suggest that NO directly facilitates osteoblastic differentiation and the cytokine-induced inhibition of AIPase activity is mediated via mechanism other than NO.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>9237637</pmid><doi>10.1016/S0014-5793(97)00597-8</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | AIPase alkaline phosphatase Alkaline Phosphatase - biosynthesis Animals Cell Differentiation - drug effects Cells, Cultured cGMP Cyclic GMP - biosynthesis cyclic guanosine monophosphate diethylamine NONOate Dinoprostone - biosynthesis EIA enzyme immunoassay Ethanamine, N-ethyl-, compound with 1,1-diethyl-2-hydroxy-2-nitrosohydrazine Hydrazines - pharmacology IL-1β Interleukin-1 - pharmacology Interleukin-1β l-NMMA Mice NG-monomethyl-l-arginine nitric oxide Nitric Oxide - pharmacology nitric oxide synthase Nitric Oxide Synthase - genetics Nitrogen Oxides Nitroprusside - pharmacology NOS NOS gene expression Osteoblastic differentiation Osteoblasts - cytology Osteoblasts - drug effects Osteocalcin - genetics PGE2 prostaglandin E2 reverse transcription-polymerase chain reaction RNA, Messenger RT-PCR SNP sodium nitroprusside TNF-α Tumor Necrosis Factor-alpha - pharmacology tumor necrosis factor-α |
| title | Direct action of nitric oxide on osteoblastic differentiation |
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