4-Heterocyclylpiperidines as Selective High-Affinity Ligands at the Human Dopamine D4 Receptor

5-(4-Chlorophenyl)-3-(1-(4-chlorobenzyl)piperidin-4-yl)pyrazole (3) was identified from screening of the Merck sample collection as a human dopamine D4 (hD4) receptor ligand with moderate affinity (61 nM) and 4-fold selectivity over human D2 (hD2) receptors. Four separate parts of the molecule have...

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Veröffentlicht in:	Journal of medicinal chemistry 1997-07, Vol.40 (15), p.2374-2385
Hauptverfasser:	Rowley, Michael, Collins, Ian, Broughton, Howard B, Davey, William B, Baker, Raymond, Emms, Frances, Marwood, Rosemarie, Patel, Shil, Patel, Smita, Ragan, C. Ian, Freedman, Stephen B, Ball, Richard, Leeson, Paul D
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cell Line Humans Ligands Medical sciences Neuropharmacology Pharmacology. Drug treatments Piperidines - metabolism Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopharmacology Receptors, Dopamine D2 - metabolism Receptors, Dopamine D4
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