Expression of matrix metalloproteinase (gelatinase) in T1 adenocarcinoma of the lung
The expression of matrix mdalloproteinase‐2 (MMP‐2; 72 kDa type IV collagenase/gelatinase A) and MMP‐9 (92 kDa type IV collagenase/gelatinase B) was Immunohisto chemically Investigated In 79 T1 adenocarcinomas of the lung using non‐commerclal polydonal anti‐MMP‐2 and ‐9 antibodies. Thirty‐two (41%)...
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| Veröffentlicht in: | Pathology international 1997-07, Vol.47 (7), p.461-469 |
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| creator | Kodate, Mantaro Kasai, Takahiko Hashirnoto, Hiroshi Yasumoto, Kosei Iwata, Yasushi Manabe, Hideo |
| description | The expression of matrix mdalloproteinase‐2 (MMP‐2; 72 kDa type IV collagenase/gelatinase A) and MMP‐9 (92 kDa type IV collagenase/gelatinase B) was Immunohisto chemically Investigated In 79 T1 adenocarcinomas of the lung using non‐commerclal polydonal anti‐MMP‐2 and ‐9 antibodies. Thirty‐two (41%) and 22 (28%) among the 79 cases were positive in the tumor cells for MMP‐2 and ‐9, respectively. The incidences of MMP‐2 and ‐9 Immunoreactivities were higher (64 and 45%, respectively) in poorly differentiated tumors than in well differentiated tumors (36 and 25%, respectively), and lower in bronchloloalveolar carcinoma (22 and 10%, respectively) compared with other subtypes of adenocarcinoma. The prognosis for patients with MMP‐2 andor ‐9 positive Immunoreactivities was significantly poorer than for those with a MMP‐negative tumor (P |
| doi_str_mv | 10.1111/j.1440-1827.1997.tb04525.x |
| format | Article |
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Thirty‐two (41%) and 22 (28%) among the 79 cases were positive in the tumor cells for MMP‐2 and ‐9, respectively. The incidences of MMP‐2 and ‐9 Immunoreactivities were higher (64 and 45%, respectively) in poorly differentiated tumors than in well differentiated tumors (36 and 25%, respectively), and lower in bronchloloalveolar carcinoma (22 and 10%, respectively) compared with other subtypes of adenocarcinoma. The prognosis for patients with MMP‐2 andor ‐9 positive Immunoreactivities was significantly poorer than for those with a MMP‐negative tumor (P<0.05). The degree of collagenization was divided into four grades, and tumors with a small to abundant amount of collagen (grade 2 and grade 3 fibrosis) had a higher Incidence of Immunoreactivity to both types of MMP. It is estimated that these expressions might be responsible for tumor Invasion, metastasis, and for grade 2 and grade 3 fibrosis In T1 adenocarcinoma of the lung.</description><identifier>ISSN: 1320-5463</identifier><identifier>EISSN: 1440-1827</identifier><identifier>DOI: 10.1111/j.1440-1827.1997.tb04525.x</identifier><identifier>PMID: 9234385</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adenocarcinoma - diagnosis ; Adenocarcinoma - metabolism ; Adenocarcinoma - mortality ; Cell Differentiation ; Collagenases - metabolism ; Female ; fibrosis ; Gelatinases - metabolism ; Humans ; Immunohistochemistry ; Lung Neoplasms - diagnosis ; Lung Neoplasms - metabolism ; Lung Neoplasms - mortality ; Male ; matrix metalloproteinase ; Matrix Metalloproteinase 2 ; Matrix Metalloproteinase 9 ; Metalloendopeptidases - metabolism ; Prognosis ; Survival Rate ; T1 adenocarcinoma of the lung ; Tumor Cells, Cultured</subject><ispartof>Pathology international, 1997-07, Vol.47 (7), p.461-469</ispartof><rights>1997 The Japanese Society of Pathology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4841-b2f040f956cbeb413d58d443625568490bf5633f112943431b0a5fd7ca7378a33</citedby><cites>FETCH-LOGICAL-c4841-b2f040f956cbeb413d58d443625568490bf5633f112943431b0a5fd7ca7378a33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1440-1827.1997.tb04525.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1440-1827.1997.tb04525.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9234385$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kodate, Mantaro</creatorcontrib><creatorcontrib>Kasai, Takahiko</creatorcontrib><creatorcontrib>Hashirnoto, Hiroshi</creatorcontrib><creatorcontrib>Yasumoto, Kosei</creatorcontrib><creatorcontrib>Iwata, Yasushi</creatorcontrib><creatorcontrib>Manabe, Hideo</creatorcontrib><title>Expression of matrix metalloproteinase (gelatinase) in T1 adenocarcinoma of the lung</title><title>Pathology international</title><addtitle>Pathol Int</addtitle><description>The expression of matrix mdalloproteinase‐2 (MMP‐2; 72 kDa type IV collagenase/gelatinase A) and MMP‐9 (92 kDa type IV collagenase/gelatinase B) was Immunohisto chemically Investigated In 79 T1 adenocarcinomas of the lung using non‐commerclal polydonal anti‐MMP‐2 and ‐9 antibodies. Thirty‐two (41%) and 22 (28%) among the 79 cases were positive in the tumor cells for MMP‐2 and ‐9, respectively. The incidences of MMP‐2 and ‐9 Immunoreactivities were higher (64 and 45%, respectively) in poorly differentiated tumors than in well differentiated tumors (36 and 25%, respectively), and lower in bronchloloalveolar carcinoma (22 and 10%, respectively) compared with other subtypes of adenocarcinoma. The prognosis for patients with MMP‐2 andor ‐9 positive Immunoreactivities was significantly poorer than for those with a MMP‐negative tumor (P<0.05). The degree of collagenization was divided into four grades, and tumors with a small to abundant amount of collagen (grade 2 and grade 3 fibrosis) had a higher Incidence of Immunoreactivity to both types of MMP. It is estimated that these expressions might be responsible for tumor Invasion, metastasis, and for grade 2 and grade 3 fibrosis In T1 adenocarcinoma of the lung.</description><subject>Adenocarcinoma - diagnosis</subject><subject>Adenocarcinoma - metabolism</subject><subject>Adenocarcinoma - mortality</subject><subject>Cell Differentiation</subject><subject>Collagenases - metabolism</subject><subject>Female</subject><subject>fibrosis</subject><subject>Gelatinases - metabolism</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Lung Neoplasms - diagnosis</subject><subject>Lung Neoplasms - metabolism</subject><subject>Lung Neoplasms - mortality</subject><subject>Male</subject><subject>matrix metalloproteinase</subject><subject>Matrix Metalloproteinase 2</subject><subject>Matrix Metalloproteinase 9</subject><subject>Metalloendopeptidases - metabolism</subject><subject>Prognosis</subject><subject>Survival Rate</subject><subject>T1 adenocarcinoma of the lung</subject><subject>Tumor Cells, Cultured</subject><issn>1320-5463</issn><issn>1440-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkF1LwzAUhoMoc05_glC8EL1oTZqPtl4IOuYcjLmLieBNSNt0ZvZjJh12_97Ult2bmxx4z_uecx4ArhD0kH13Gw8RAl0U-oGHoijw6hgS6lOvOQLDg3Rsa-xDlxKGT8GZMRsIUYAZHIBB5GOCQzoEq0mz1dIYVZVOlTmFqLVqnELWIs-rra5qqUphpHOzlrmo_-pbR5XOCjkilWWVCJ2osipE664_pZPvyvU5OMlEbuRF_4_A2_NkNX5x56_T2fhx7iYkJMiN_QwSmEWUJbGMCcIpDVNCMPMpZSGJYJxRhnGGkB8Ruy-KoaBZGiQiwEEoMB6B6y7XLvq9k6bmhTKJzHNRympneBAh2l5sG--7xkRXxmiZ8a1WhdB7jiBvkfINb7nxlhtvkfIeKW-s-bKfsosLmR6sPUOrP3T6j8rl_h_JfDlbEIZsgNsFKFPL5hAg9Bdn9lLK3xdTPqckXD59UM7wL9BGlJE</recordid><startdate>199707</startdate><enddate>199707</enddate><creator>Kodate, Mantaro</creator><creator>Kasai, Takahiko</creator><creator>Hashirnoto, Hiroshi</creator><creator>Yasumoto, Kosei</creator><creator>Iwata, Yasushi</creator><creator>Manabe, Hideo</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199707</creationdate><title>Expression of matrix metalloproteinase (gelatinase) in T1 adenocarcinoma of the lung</title><author>Kodate, Mantaro ; Kasai, Takahiko ; Hashirnoto, Hiroshi ; Yasumoto, Kosei ; Iwata, Yasushi ; Manabe, Hideo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4841-b2f040f956cbeb413d58d443625568490bf5633f112943431b0a5fd7ca7378a33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adenocarcinoma - diagnosis</topic><topic>Adenocarcinoma - metabolism</topic><topic>Adenocarcinoma - mortality</topic><topic>Cell Differentiation</topic><topic>Collagenases - metabolism</topic><topic>Female</topic><topic>fibrosis</topic><topic>Gelatinases - metabolism</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Lung Neoplasms - diagnosis</topic><topic>Lung Neoplasms - metabolism</topic><topic>Lung Neoplasms - mortality</topic><topic>Male</topic><topic>matrix metalloproteinase</topic><topic>Matrix Metalloproteinase 2</topic><topic>Matrix Metalloproteinase 9</topic><topic>Metalloendopeptidases - metabolism</topic><topic>Prognosis</topic><topic>Survival Rate</topic><topic>T1 adenocarcinoma of the lung</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kodate, Mantaro</creatorcontrib><creatorcontrib>Kasai, Takahiko</creatorcontrib><creatorcontrib>Hashirnoto, Hiroshi</creatorcontrib><creatorcontrib>Yasumoto, Kosei</creatorcontrib><creatorcontrib>Iwata, Yasushi</creatorcontrib><creatorcontrib>Manabe, Hideo</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pathology international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kodate, Mantaro</au><au>Kasai, Takahiko</au><au>Hashirnoto, Hiroshi</au><au>Yasumoto, Kosei</au><au>Iwata, Yasushi</au><au>Manabe, Hideo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of matrix metalloproteinase (gelatinase) in T1 adenocarcinoma of the lung</atitle><jtitle>Pathology international</jtitle><addtitle>Pathol Int</addtitle><date>1997-07</date><risdate>1997</risdate><volume>47</volume><issue>7</issue><spage>461</spage><epage>469</epage><pages>461-469</pages><issn>1320-5463</issn><eissn>1440-1827</eissn><abstract>The expression of matrix mdalloproteinase‐2 (MMP‐2; 72 kDa type IV collagenase/gelatinase A) and MMP‐9 (92 kDa type IV collagenase/gelatinase B) was Immunohisto chemically Investigated In 79 T1 adenocarcinomas of the lung using non‐commerclal polydonal anti‐MMP‐2 and ‐9 antibodies. Thirty‐two (41%) and 22 (28%) among the 79 cases were positive in the tumor cells for MMP‐2 and ‐9, respectively. The incidences of MMP‐2 and ‐9 Immunoreactivities were higher (64 and 45%, respectively) in poorly differentiated tumors than in well differentiated tumors (36 and 25%, respectively), and lower in bronchloloalveolar carcinoma (22 and 10%, respectively) compared with other subtypes of adenocarcinoma. The prognosis for patients with MMP‐2 andor ‐9 positive Immunoreactivities was significantly poorer than for those with a MMP‐negative tumor (P<0.05). The degree of collagenization was divided into four grades, and tumors with a small to abundant amount of collagen (grade 2 and grade 3 fibrosis) had a higher Incidence of Immunoreactivity to both types of MMP. It is estimated that these expressions might be responsible for tumor Invasion, metastasis, and for grade 2 and grade 3 fibrosis In T1 adenocarcinoma of the lung.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>9234385</pmid><doi>10.1111/j.1440-1827.1997.tb04525.x</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adenocarcinoma - diagnosis Adenocarcinoma - metabolism Adenocarcinoma - mortality Cell Differentiation Collagenases - metabolism Female fibrosis Gelatinases - metabolism Humans Immunohistochemistry Lung Neoplasms - diagnosis Lung Neoplasms - metabolism Lung Neoplasms - mortality Male matrix metalloproteinase Matrix Metalloproteinase 2 Matrix Metalloproteinase 9 Metalloendopeptidases - metabolism Prognosis Survival Rate T1 adenocarcinoma of the lung Tumor Cells, Cultured |
| title | Expression of matrix metalloproteinase (gelatinase) in T1 adenocarcinoma of the lung |
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