CYP26, a Novel Mammalian Cytochrome P450, Is Induced by Retinoic Acid and Defines a New Family
A novel member of the cytochrome P450 superfamily, CYP26, which represents a new family of cytochrome P450 enzymes, has been cloned. CYP26 mRNA is up-regulated during the retinoic acid (RA)-induced neural differentiation of mouse embryonic stem cells in vitro and is transiently expressed by embryoni...
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Veröffentlicht in: | The Journal of biological chemistry 1997-07, Vol.272 (30), p.18702-18708 |
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creator | Ray, William J. Bain, Gerard Yao, Min Gottlieb, David I. |
description | A novel member of the cytochrome P450 superfamily, CYP26, which represents a new family of cytochrome P450 enzymes, has been cloned. CYP26 mRNA is up-regulated during the retinoic acid (RA)-induced neural differentiation of mouse embryonic stem cells in vitro and is transiently expressed by embryonic stem cells undergoing predominantly non-neural differentiation. CYP26 transcript is detectable as early as embryonic day 8.5 in mouse embryos, suggesting a function for the gene in early development. CYP26 is expressed in mouse and human liver, as expected for a cytochrome P450, and is also expressed in regions of the brain and the placenta. Acute administration of 100 mg/kg all-trans-RA increases steady-state levels of transcript in the adult liver, but not in the brain. CYP26 is highly homologous to a Zebrafish gene, CYPRA1, which has been proposed to participate in the degradation of RA, but is minimally homologous to other mammalian cytochrome P450 proteins. Thus, we report the cloning of a member of a novel cytochrome P450 family that is expressed in mammalian embryos and in brain and is induced by RA in the liver. |
doi_str_mv | 10.1074/jbc.272.30.18702 |
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CYP26 mRNA is up-regulated during the retinoic acid (RA)-induced neural differentiation of mouse embryonic stem cells in vitro and is transiently expressed by embryonic stem cells undergoing predominantly non-neural differentiation. CYP26 transcript is detectable as early as embryonic day 8.5 in mouse embryos, suggesting a function for the gene in early development. CYP26 is expressed in mouse and human liver, as expected for a cytochrome P450, and is also expressed in regions of the brain and the placenta. Acute administration of 100 mg/kg all-trans-RA increases steady-state levels of transcript in the adult liver, but not in the brain. CYP26 is highly homologous to a Zebrafish gene, CYPRA1, which has been proposed to participate in the degradation of RA, but is minimally homologous to other mammalian cytochrome P450 proteins. Thus, we report the cloning of a member of a novel cytochrome P450 family that is expressed in mammalian embryos and in brain and is induced by RA in the liver.</description><identifier>ISSN: 0021-9258</identifier><identifier>EISSN: 1083-351X</identifier><identifier>DOI: 10.1074/jbc.272.30.18702</identifier><identifier>PMID: 9228041</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Amino Acid Sequence ; Animals ; Base Sequence ; Brain - enzymology ; Cell Differentiation - drug effects ; Cells, Cultured ; Cloning, Molecular ; Cytochrome P-450 Enzyme System - biosynthesis ; Cytochrome P-450 Enzyme System - genetics ; Embryo, Mammalian - enzymology ; Embryo, Nonmammalian ; Enzyme Induction ; Humans ; Liver - enzymology ; Mice ; Molecular Sequence Data ; Neurons - enzymology ; Placenta - enzymology ; RNA, Messenger - metabolism ; Sequence Alignment ; Software ; Stem Cells - cytology ; Stem Cells - enzymology ; Tretinoin - pharmacology ; Tumor Cells, Cultured ; Zebrafish</subject><ispartof>The Journal of biological chemistry, 1997-07, Vol.272 (30), p.18702-18708</ispartof><rights>1997 © 1997 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c513t-cd50a4e0ec30cc8e9d91e0da7390e0d20db638795101890c3f0f5bbb944eb6543</citedby><cites>FETCH-LOGICAL-c513t-cd50a4e0ec30cc8e9d91e0da7390e0d20db638795101890c3f0f5bbb944eb6543</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9228041$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ray, William J.</creatorcontrib><creatorcontrib>Bain, Gerard</creatorcontrib><creatorcontrib>Yao, Min</creatorcontrib><creatorcontrib>Gottlieb, David I.</creatorcontrib><title>CYP26, a Novel Mammalian Cytochrome P450, Is Induced by Retinoic Acid and Defines a New Family</title><title>The Journal of biological chemistry</title><addtitle>J Biol Chem</addtitle><description>A novel member of the cytochrome P450 superfamily, CYP26, which represents a new family of cytochrome P450 enzymes, has been cloned. CYP26 mRNA is up-regulated during the retinoic acid (RA)-induced neural differentiation of mouse embryonic stem cells in vitro and is transiently expressed by embryonic stem cells undergoing predominantly non-neural differentiation. CYP26 transcript is detectable as early as embryonic day 8.5 in mouse embryos, suggesting a function for the gene in early development. CYP26 is expressed in mouse and human liver, as expected for a cytochrome P450, and is also expressed in regions of the brain and the placenta. Acute administration of 100 mg/kg all-trans-RA increases steady-state levels of transcript in the adult liver, but not in the brain. CYP26 is highly homologous to a Zebrafish gene, CYPRA1, which has been proposed to participate in the degradation of RA, but is minimally homologous to other mammalian cytochrome P450 proteins. Thus, we report the cloning of a member of a novel cytochrome P450 family that is expressed in mammalian embryos and in brain and is induced by RA in the liver.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>Brain - enzymology</subject><subject>Cell Differentiation - drug effects</subject><subject>Cells, Cultured</subject><subject>Cloning, Molecular</subject><subject>Cytochrome P-450 Enzyme System - biosynthesis</subject><subject>Cytochrome P-450 Enzyme System - genetics</subject><subject>Embryo, Mammalian - enzymology</subject><subject>Embryo, Nonmammalian</subject><subject>Enzyme Induction</subject><subject>Humans</subject><subject>Liver - enzymology</subject><subject>Mice</subject><subject>Molecular Sequence Data</subject><subject>Neurons - enzymology</subject><subject>Placenta - enzymology</subject><subject>RNA, Messenger - metabolism</subject><subject>Sequence Alignment</subject><subject>Software</subject><subject>Stem Cells - cytology</subject><subject>Stem Cells - enzymology</subject><subject>Tretinoin - pharmacology</subject><subject>Tumor Cells, Cultured</subject><subject>Zebrafish</subject><issn>0021-9258</issn><issn>1083-351X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMlLXEEQh5ugmFFz9yL0IeTkm1Qvb-ncZOIyoFHEQHJJ00u9TMtb9PUbZf57e5ghByFYl6L4LRQfIUcMpgxK-fXBuikv-VSkuyqBfyATBpXIRM5-7ZAJAGeZ4nn1kezH-ABppGJ7ZE9xXoFkE_Jn9vuWFyfU0B_9Mzb02rStaYLp6Gw19m4x9C3SW5nDCZ1HOu_80qGndkXvcAxdHxw9dcFT03n6HevQYVxX4Qs9N21oVodktzZNxE_bfUB-np_dzy6zq5uL-ez0KnM5E2PmfA5GIqAT4FyFyiuG4E0pFKTNwdtCVKXKGbBKgRM11Lm1VkmJtsilOCBfNr2PQ_-0xDjqNkSHTWM67JdRl4rJUhbwrpEVUBZKimSEjdENfYwD1vpxCK0ZVpqBXrPXib1O7LVI95p9ihxvu5e2Rf8vsIWd9M8bfRH-Ll7CgNqGhBjbtzXfNjZMwJ4DDjq6gF3iniJu1L4P___hFdSJm5Y</recordid><startdate>19970725</startdate><enddate>19970725</enddate><creator>Ray, William J.</creator><creator>Bain, Gerard</creator><creator>Yao, Min</creator><creator>Gottlieb, David I.</creator><general>Elsevier Inc</general><general>American Society for Biochemistry and Molecular Biology</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19970725</creationdate><title>CYP26, a Novel Mammalian Cytochrome P450, Is Induced by Retinoic Acid and Defines a New Family</title><author>Ray, William J. ; Bain, Gerard ; Yao, Min ; Gottlieb, David I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c513t-cd50a4e0ec30cc8e9d91e0da7390e0d20db638795101890c3f0f5bbb944eb6543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>Brain - enzymology</topic><topic>Cell Differentiation - drug effects</topic><topic>Cells, Cultured</topic><topic>Cloning, Molecular</topic><topic>Cytochrome P-450 Enzyme System - biosynthesis</topic><topic>Cytochrome P-450 Enzyme System - genetics</topic><topic>Embryo, Mammalian - enzymology</topic><topic>Embryo, Nonmammalian</topic><topic>Enzyme Induction</topic><topic>Humans</topic><topic>Liver - enzymology</topic><topic>Mice</topic><topic>Molecular Sequence Data</topic><topic>Neurons - enzymology</topic><topic>Placenta - enzymology</topic><topic>RNA, Messenger - metabolism</topic><topic>Sequence Alignment</topic><topic>Software</topic><topic>Stem Cells - cytology</topic><topic>Stem Cells - enzymology</topic><topic>Tretinoin - pharmacology</topic><topic>Tumor Cells, Cultured</topic><topic>Zebrafish</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ray, William J.</creatorcontrib><creatorcontrib>Bain, Gerard</creatorcontrib><creatorcontrib>Yao, Min</creatorcontrib><creatorcontrib>Gottlieb, David I.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of biological chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ray, William J.</au><au>Bain, Gerard</au><au>Yao, Min</au><au>Gottlieb, David I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CYP26, a Novel Mammalian Cytochrome P450, Is Induced by Retinoic Acid and Defines a New Family</atitle><jtitle>The Journal of biological chemistry</jtitle><addtitle>J Biol Chem</addtitle><date>1997-07-25</date><risdate>1997</risdate><volume>272</volume><issue>30</issue><spage>18702</spage><epage>18708</epage><pages>18702-18708</pages><issn>0021-9258</issn><eissn>1083-351X</eissn><abstract>A novel member of the cytochrome P450 superfamily, CYP26, which represents a new family of cytochrome P450 enzymes, has been cloned. CYP26 mRNA is up-regulated during the retinoic acid (RA)-induced neural differentiation of mouse embryonic stem cells in vitro and is transiently expressed by embryonic stem cells undergoing predominantly non-neural differentiation. CYP26 transcript is detectable as early as embryonic day 8.5 in mouse embryos, suggesting a function for the gene in early development. CYP26 is expressed in mouse and human liver, as expected for a cytochrome P450, and is also expressed in regions of the brain and the placenta. Acute administration of 100 mg/kg all-trans-RA increases steady-state levels of transcript in the adult liver, but not in the brain. CYP26 is highly homologous to a Zebrafish gene, CYPRA1, which has been proposed to participate in the degradation of RA, but is minimally homologous to other mammalian cytochrome P450 proteins. 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subjects | Amino Acid Sequence Animals Base Sequence Brain - enzymology Cell Differentiation - drug effects Cells, Cultured Cloning, Molecular Cytochrome P-450 Enzyme System - biosynthesis Cytochrome P-450 Enzyme System - genetics Embryo, Mammalian - enzymology Embryo, Nonmammalian Enzyme Induction Humans Liver - enzymology Mice Molecular Sequence Data Neurons - enzymology Placenta - enzymology RNA, Messenger - metabolism Sequence Alignment Software Stem Cells - cytology Stem Cells - enzymology Tretinoin - pharmacology Tumor Cells, Cultured Zebrafish |
title | CYP26, a Novel Mammalian Cytochrome P450, Is Induced by Retinoic Acid and Defines a New Family |
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