A new small particle packing for faster analysis with high resolution
The need for fast and efficient separations of complex samples such as pharmaceuticals and biologicals led to the development of fast, efficient, and reproducible 3.5 μm columns. Separations using 3.5 μm column are 30–50% faster at equal plate-count compared to 5 μm columns. The results show that th...
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| Veröffentlicht in: | Journal of pharmaceutical and biomedical analysis 1997-06, Vol.15 (9), p.1389-1395 |
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| container_issue | 9 |
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| container_title | Journal of pharmaceutical and biomedical analysis |
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| creator | Phillips, Dorothy J. Capparella, Mark Neue, Uwe D. Fallah, Zoubair El |
| description | The need for fast and efficient separations of complex samples such as pharmaceuticals and biologicals led to the development of fast, efficient, and reproducible 3.5 μm columns. Separations using 3.5 μm column are 30–50% faster at equal plate-count compared to 5 μm columns. The results show that the 3.5 μm columns (100 mm length) give the same efficiency and resolution of drug impurities as the 5 μm columns (150 mm length). For many analytical methods, switching to 3.5 μm columns saves time and reduces costs. Separation methodologies using 5 μm columns are easily modified to accommodate 3.5 μm columns of the same chemistry because efficiency, resolution and sensitivity remain the same. It is shown that 3.5 μm columns have lifetimes comparable to 5 μm columns of the same brand. |
| doi_str_mv | 10.1016/S0731-7085(96)02049-3 |
| format | Article |
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Separations using 3.5 μm column are 30–50% faster at equal plate-count compared to 5 μm columns. The results show that the 3.5 μm columns (100 mm length) give the same efficiency and resolution of drug impurities as the 5 μm columns (150 mm length). For many analytical methods, switching to 3.5 μm columns saves time and reduces costs. Separation methodologies using 5 μm columns are easily modified to accommodate 3.5 μm columns of the same chemistry because efficiency, resolution and sensitivity remain the same. It is shown that 3.5 μm columns have lifetimes comparable to 5 μm columns of the same brand.</description><identifier>ISSN: 0731-7085</identifier><identifier>EISSN: 1873-264X</identifier><identifier>DOI: 10.1016/S0731-7085(96)02049-3</identifier><identifier>PMID: 9226568</identifier><identifier>CODEN: JPBADA</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Analysis ; Analysis of pharmaceuticals ; Animals ; Beclomethasone - blood ; Biological and medical sciences ; Chromatography, High Pressure Liquid - instrumentation ; Column lifetime ; Drug Stability ; Fast chromatography ; General pharmacology ; Medical sciences ; Paclitaxel - blood ; Particle Size ; Pharmacology. 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Separations using 3.5 μm column are 30–50% faster at equal plate-count compared to 5 μm columns. The results show that the 3.5 μm columns (100 mm length) give the same efficiency and resolution of drug impurities as the 5 μm columns (150 mm length). For many analytical methods, switching to 3.5 μm columns saves time and reduces costs. Separation methodologies using 5 μm columns are easily modified to accommodate 3.5 μm columns of the same chemistry because efficiency, resolution and sensitivity remain the same. It is shown that 3.5 μm columns have lifetimes comparable to 5 μm columns of the same brand.</description><subject>Analysis</subject><subject>Analysis of pharmaceuticals</subject><subject>Animals</subject><subject>Beclomethasone - blood</subject><subject>Biological and medical sciences</subject><subject>Chromatography, High Pressure Liquid - instrumentation</subject><subject>Column lifetime</subject><subject>Drug Stability</subject><subject>Fast chromatography</subject><subject>General pharmacology</subject><subject>Medical sciences</subject><subject>Paclitaxel - blood</subject><subject>Particle Size</subject><subject>Pharmacology. Drug treatments</subject><subject>Rabbits</subject><subject>Reproducibility of Results</subject><subject>Reversed-phase HPLC</subject><subject>Small particle HPLC packings</subject><subject>Sulfanilamides - blood</subject><subject>Tamoxifen - blood</subject><subject>Time Factors</subject><issn>0731-7085</issn><issn>1873-264X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LAzEQhoMoWj9-QiEHET2s5muTzUmK1A8oeFDBW8hmZ9touluTraX_3tWWXj3NwDzvzPAgNKTkmhIqb16I4jRTpMgvtbwijAid8T00oIXiGZPifR8NdsgROk7pgxCSUy0O0aFmTOayGKDxCDewwmluQ8ALGzvvAvSN-_TNFNdtxLVNHURsGxvWySe88t0Mz_x0hiOkNiw73zan6KC2IcHZtp6gt_vx691jNnl-eLobTTLHC91lVVkKrbmS1ikrWK2VLUTlClFKTSkDVQtggpWqLGrBnSIaqsoxyStVOiIkP0EXm72L2H4tIXVm7pODEGwD7TIZpamQrMh7MN-ALrYpRajNIvq5jWtDifnVZ_70mV83Rkvzp8_wPjfcHliWc6h2qa2vfn6-ndvkbKijbZxPO4wp2a8lPXa7waCX8e0hmuQ8NA4qH8F1pmr9P4_8AD-Ei_4</recordid><startdate>19970601</startdate><enddate>19970601</enddate><creator>Phillips, Dorothy J.</creator><creator>Capparella, Mark</creator><creator>Neue, Uwe D.</creator><creator>Fallah, Zoubair El</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19970601</creationdate><title>A new small particle packing for faster analysis with high resolution</title><author>Phillips, Dorothy J. ; Capparella, Mark ; Neue, Uwe D. ; Fallah, Zoubair El</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-dbb499376ac7a42f97a84dc84b69112e7f4e242b7b8f43c709eddc263d7bc0463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Analysis</topic><topic>Analysis of pharmaceuticals</topic><topic>Animals</topic><topic>Beclomethasone - blood</topic><topic>Biological and medical sciences</topic><topic>Chromatography, High Pressure Liquid - instrumentation</topic><topic>Column lifetime</topic><topic>Drug Stability</topic><topic>Fast chromatography</topic><topic>General pharmacology</topic><topic>Medical sciences</topic><topic>Paclitaxel - blood</topic><topic>Particle Size</topic><topic>Pharmacology. Drug treatments</topic><topic>Rabbits</topic><topic>Reproducibility of Results</topic><topic>Reversed-phase HPLC</topic><topic>Small particle HPLC packings</topic><topic>Sulfanilamides - blood</topic><topic>Tamoxifen - blood</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Phillips, Dorothy J.</creatorcontrib><creatorcontrib>Capparella, Mark</creatorcontrib><creatorcontrib>Neue, Uwe D.</creatorcontrib><creatorcontrib>Fallah, Zoubair El</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Phillips, Dorothy J.</au><au>Capparella, Mark</au><au>Neue, Uwe D.</au><au>Fallah, Zoubair El</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A new small particle packing for faster analysis with high resolution</atitle><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle><addtitle>J Pharm Biomed Anal</addtitle><date>1997-06-01</date><risdate>1997</risdate><volume>15</volume><issue>9</issue><spage>1389</spage><epage>1395</epage><pages>1389-1395</pages><issn>0731-7085</issn><eissn>1873-264X</eissn><coden>JPBADA</coden><abstract>The need for fast and efficient separations of complex samples such as pharmaceuticals and biologicals led to the development of fast, efficient, and reproducible 3.5 μm columns. 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| identifier | ISSN: 0731-7085 |
| ispartof | Journal of pharmaceutical and biomedical analysis, 1997-06, Vol.15 (9), p.1389-1395 |
| issn | 0731-7085 1873-264X |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Analysis Analysis of pharmaceuticals Animals Beclomethasone - blood Biological and medical sciences Chromatography, High Pressure Liquid - instrumentation Column lifetime Drug Stability Fast chromatography General pharmacology Medical sciences Paclitaxel - blood Particle Size Pharmacology. Drug treatments Rabbits Reproducibility of Results Reversed-phase HPLC Small particle HPLC packings Sulfanilamides - blood Tamoxifen - blood Time Factors |
| title | A new small particle packing for faster analysis with high resolution |
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