Assessment of Age-Dependent Immunity to Malaria in Transmigrants
Sixty-six Javanese transmigrants moving from Java, an area of very low malaria transmission, to Irian Jaya, an area of high malaria transmission, were monitored to evaluate the effects of exposure to malaria transmission and age on resistance to infection and the induction of humoral immunity. The r...
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| Veröffentlicht in: | The American journal of tropical medicine and hygiene 1997-06, Vol.56 (6), p.647-649 |
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| container_title | The American journal of tropical medicine and hygiene |
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| creator | Andersen, Ellen Jones, Trevor R Purnomo Masbar, Sofyan Wiady, Iwa Tirtolusumo, Soekartono Bangs, Michael J Charoenvit, Yupin Gunawan, Suriadi Hoffman, Stephen L |
| description | Sixty-six Javanese transmigrants moving from Java, an area of very low malaria transmission, to Irian Jaya, an area of high malaria transmission, were monitored to evaluate the effects of exposure to malaria transmission and age on resistance to infection and the induction of humoral immunity. The risk of acquiring Plasmodium falciparum parasitemia was not statistically greater in children (5-15 years of age) than in adults (> 15 years of age) during the first 14 months of exposure. However, during the cross-sectional survey at 14 months of exposure. children did have significantly higher P. falciparum asexual blood-stage parasite densities. Serum antibody titers to R32LR, a peptide containing sequences from the P. falciparum circumsporozoite repeat region, and MSP19, a proteolytic fragment of merozoite surface protein-1 (MSP-1) from P. falciparum, were measured by enzyme-linked immunosorbent assay. Exposure for both six and 14 months produced statistically significant increased antibody titers to both R32LR and MSP-1; no age-dependent difference in antibody titers was observed. In this population, exposure to malaria transmission induced antibodies to antigens associated with immunity to malaria. In addition, we noted an age-dependent difference in the parasitemia density of P. falciparum. |
| doi_str_mv | 10.4269/ajtmh.1997.56.647 |
| format | Article |
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The risk of acquiring Plasmodium falciparum parasitemia was not statistically greater in children (5-15 years of age) than in adults (> 15 years of age) during the first 14 months of exposure. However, during the cross-sectional survey at 14 months of exposure. children did have significantly higher P. falciparum asexual blood-stage parasite densities. Serum antibody titers to R32LR, a peptide containing sequences from the P. falciparum circumsporozoite repeat region, and MSP19, a proteolytic fragment of merozoite surface protein-1 (MSP-1) from P. falciparum, were measured by enzyme-linked immunosorbent assay. Exposure for both six and 14 months produced statistically significant increased antibody titers to both R32LR and MSP-1; no age-dependent difference in antibody titers was observed. In this population, exposure to malaria transmission induced antibodies to antigens associated with immunity to malaria. In addition, we noted an age-dependent difference in the parasitemia density of P. falciparum.</description><identifier>ISSN: 0002-9637</identifier><identifier>EISSN: 1476-1645</identifier><identifier>DOI: 10.4269/ajtmh.1997.56.647</identifier><identifier>PMID: 9230797</identifier><identifier>CODEN: AJTHAB</identifier><language>eng</language><publisher>Lawrence, KS: ASTMH</publisher><subject>Adolescent ; Adult ; Aging - immunology ; Animals ; Antibodies, Protozoan - blood ; Antibody Formation ; Antigens, Protozoan - isolation & purification ; Biological and medical sciences ; Child ; Child, Preschool ; Enzyme-Linked Immunosorbent Assay ; Female ; Human protozoal diseases ; Humans ; Immunity, Innate ; Indonesia - epidemiology ; Indonesia - ethnology ; Infectious diseases ; Malaria ; Malaria, Falciparum - epidemiology ; Malaria, Falciparum - immunology ; Malaria, Falciparum - transmission ; Malaria, Vivax - epidemiology ; Male ; Medical sciences ; Parasitic diseases ; Plasmodium falciparum - immunology ; Plasmodium falciparum - isolation & purification ; Plasmodium vivax - isolation & purification ; Prevalence ; Protozoal diseases ; Transients and Migrants ; Tropical medicine</subject><ispartof>The American journal of tropical medicine and hygiene, 1997-06, Vol.56 (6), p.647-649</ispartof><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-6e3428ef53ee558c8a16132e06d9bd3ac61bb47846a0e7d32841ed515b30a73e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2744545$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9230797$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Andersen, Ellen</creatorcontrib><creatorcontrib>Jones, Trevor R</creatorcontrib><creatorcontrib>Purnomo</creatorcontrib><creatorcontrib>Masbar, Sofyan</creatorcontrib><creatorcontrib>Wiady, Iwa</creatorcontrib><creatorcontrib>Tirtolusumo, Soekartono</creatorcontrib><creatorcontrib>Bangs, Michael J</creatorcontrib><creatorcontrib>Charoenvit, Yupin</creatorcontrib><creatorcontrib>Gunawan, Suriadi</creatorcontrib><creatorcontrib>Hoffman, Stephen L</creatorcontrib><title>Assessment of Age-Dependent Immunity to Malaria in Transmigrants</title><title>The American journal of tropical medicine and hygiene</title><addtitle>Am J Trop Med Hyg</addtitle><description>Sixty-six Javanese transmigrants moving from Java, an area of very low malaria transmission, to Irian Jaya, an area of high malaria transmission, were monitored to evaluate the effects of exposure to malaria transmission and age on resistance to infection and the induction of humoral immunity. The risk of acquiring Plasmodium falciparum parasitemia was not statistically greater in children (5-15 years of age) than in adults (> 15 years of age) during the first 14 months of exposure. However, during the cross-sectional survey at 14 months of exposure. children did have significantly higher P. falciparum asexual blood-stage parasite densities. Serum antibody titers to R32LR, a peptide containing sequences from the P. falciparum circumsporozoite repeat region, and MSP19, a proteolytic fragment of merozoite surface protein-1 (MSP-1) from P. falciparum, were measured by enzyme-linked immunosorbent assay. Exposure for both six and 14 months produced statistically significant increased antibody titers to both R32LR and MSP-1; no age-dependent difference in antibody titers was observed. In this population, exposure to malaria transmission induced antibodies to antigens associated with immunity to malaria. In addition, we noted an age-dependent difference in the parasitemia density of P. falciparum.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aging - immunology</subject><subject>Animals</subject><subject>Antibodies, Protozoan - blood</subject><subject>Antibody Formation</subject><subject>Antigens, Protozoan - isolation & purification</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Human protozoal diseases</subject><subject>Humans</subject><subject>Immunity, Innate</subject><subject>Indonesia - epidemiology</subject><subject>Indonesia - ethnology</subject><subject>Infectious diseases</subject><subject>Malaria</subject><subject>Malaria, Falciparum - epidemiology</subject><subject>Malaria, Falciparum - immunology</subject><subject>Malaria, Falciparum - transmission</subject><subject>Malaria, Vivax - epidemiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Parasitic diseases</subject><subject>Plasmodium falciparum - immunology</subject><subject>Plasmodium falciparum - isolation & purification</subject><subject>Plasmodium vivax - isolation & purification</subject><subject>Prevalence</subject><subject>Protozoal diseases</subject><subject>Transients and Migrants</subject><subject>Tropical medicine</subject><issn>0002-9637</issn><issn>1476-1645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1r20AQhpfSkDppf0APBR2a3OTs7PfeatKvQEIv6XlZSSN7g1ZyNTIm_z5ybHLtaWDmed-Bh7HPwJdKGH8Tn6a8WYL3dqnN0ij7ji1AWVOCUfo9W3DORemNtB_YBdET5-AEwDk790Jy6-2CfVsRIVHGfiqGtlitsfyOW-ybw-Iu512fpudiGoqH2MUxxSL1xeMYe8ppPY-JPrKzNnaEn07zkv39-ePx9nd5_-fX3e3qvqylM1NpUCrhsNUSUWtXuwgGpEBuGl81MtYGqkpZp0zkaBspnAJsNOhK8mglykt2fezdjsO_HdIUcqIauy72OOwoWA9Kecf_C4IRwhlpZhCOYD0ORCO2YTumHMfnADwc9IZXveGgN2gTZr1z5supfFdlbN4SJ5_z_evpHqmOXTsrqhO9YcIqpZWesasjtknrzT6NGCjHrptLIez3-8Oz13cvmTSP4w</recordid><startdate>19970601</startdate><enddate>19970601</enddate><creator>Andersen, Ellen</creator><creator>Jones, Trevor R</creator><creator>Purnomo</creator><creator>Masbar, Sofyan</creator><creator>Wiady, Iwa</creator><creator>Tirtolusumo, Soekartono</creator><creator>Bangs, Michael J</creator><creator>Charoenvit, Yupin</creator><creator>Gunawan, Suriadi</creator><creator>Hoffman, Stephen L</creator><general>ASTMH</general><general>Allen Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>19970601</creationdate><title>Assessment of Age-Dependent Immunity to Malaria in Transmigrants</title><author>Andersen, Ellen ; Jones, Trevor R ; Purnomo ; Masbar, Sofyan ; Wiady, Iwa ; Tirtolusumo, Soekartono ; Bangs, Michael J ; Charoenvit, Yupin ; Gunawan, Suriadi ; Hoffman, Stephen L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-6e3428ef53ee558c8a16132e06d9bd3ac61bb47846a0e7d32841ed515b30a73e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aging - immunology</topic><topic>Animals</topic><topic>Antibodies, Protozoan - blood</topic><topic>Antibody Formation</topic><topic>Antigens, Protozoan - isolation & purification</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Human protozoal diseases</topic><topic>Humans</topic><topic>Immunity, Innate</topic><topic>Indonesia - epidemiology</topic><topic>Indonesia - ethnology</topic><topic>Infectious diseases</topic><topic>Malaria</topic><topic>Malaria, Falciparum - epidemiology</topic><topic>Malaria, Falciparum - immunology</topic><topic>Malaria, Falciparum - transmission</topic><topic>Malaria, Vivax - epidemiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Parasitic diseases</topic><topic>Plasmodium falciparum - immunology</topic><topic>Plasmodium falciparum - isolation & purification</topic><topic>Plasmodium vivax - isolation & purification</topic><topic>Prevalence</topic><topic>Protozoal diseases</topic><topic>Transients and Migrants</topic><topic>Tropical medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Andersen, Ellen</creatorcontrib><creatorcontrib>Jones, Trevor R</creatorcontrib><creatorcontrib>Purnomo</creatorcontrib><creatorcontrib>Masbar, Sofyan</creatorcontrib><creatorcontrib>Wiady, Iwa</creatorcontrib><creatorcontrib>Tirtolusumo, Soekartono</creatorcontrib><creatorcontrib>Bangs, Michael J</creatorcontrib><creatorcontrib>Charoenvit, Yupin</creatorcontrib><creatorcontrib>Gunawan, Suriadi</creatorcontrib><creatorcontrib>Hoffman, Stephen L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of tropical medicine and hygiene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Andersen, Ellen</au><au>Jones, Trevor R</au><au>Purnomo</au><au>Masbar, Sofyan</au><au>Wiady, Iwa</au><au>Tirtolusumo, Soekartono</au><au>Bangs, Michael J</au><au>Charoenvit, Yupin</au><au>Gunawan, Suriadi</au><au>Hoffman, Stephen L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessment of Age-Dependent Immunity to Malaria in Transmigrants</atitle><jtitle>The American journal of tropical medicine and hygiene</jtitle><addtitle>Am J Trop Med Hyg</addtitle><date>1997-06-01</date><risdate>1997</risdate><volume>56</volume><issue>6</issue><spage>647</spage><epage>649</epage><pages>647-649</pages><issn>0002-9637</issn><eissn>1476-1645</eissn><coden>AJTHAB</coden><abstract>Sixty-six Javanese transmigrants moving from Java, an area of very low malaria transmission, to Irian Jaya, an area of high malaria transmission, were monitored to evaluate the effects of exposure to malaria transmission and age on resistance to infection and the induction of humoral immunity. The risk of acquiring Plasmodium falciparum parasitemia was not statistically greater in children (5-15 years of age) than in adults (> 15 years of age) during the first 14 months of exposure. However, during the cross-sectional survey at 14 months of exposure. children did have significantly higher P. falciparum asexual blood-stage parasite densities. Serum antibody titers to R32LR, a peptide containing sequences from the P. falciparum circumsporozoite repeat region, and MSP19, a proteolytic fragment of merozoite surface protein-1 (MSP-1) from P. falciparum, were measured by enzyme-linked immunosorbent assay. Exposure for both six and 14 months produced statistically significant increased antibody titers to both R32LR and MSP-1; no age-dependent difference in antibody titers was observed. In this population, exposure to malaria transmission induced antibodies to antigens associated with immunity to malaria. In addition, we noted an age-dependent difference in the parasitemia density of P. falciparum.</abstract><cop>Lawrence, KS</cop><pub>ASTMH</pub><pmid>9230797</pmid><doi>10.4269/ajtmh.1997.56.647</doi><tpages>3</tpages></addata></record> |
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| subjects | Adolescent Adult Aging - immunology Animals Antibodies, Protozoan - blood Antibody Formation Antigens, Protozoan - isolation & purification Biological and medical sciences Child Child, Preschool Enzyme-Linked Immunosorbent Assay Female Human protozoal diseases Humans Immunity, Innate Indonesia - epidemiology Indonesia - ethnology Infectious diseases Malaria Malaria, Falciparum - epidemiology Malaria, Falciparum - immunology Malaria, Falciparum - transmission Malaria, Vivax - epidemiology Male Medical sciences Parasitic diseases Plasmodium falciparum - immunology Plasmodium falciparum - isolation & purification Plasmodium vivax - isolation & purification Prevalence Protozoal diseases Transients and Migrants Tropical medicine |
| title | Assessment of Age-Dependent Immunity to Malaria in Transmigrants |
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