Maternal manipulation of brown adipose tissue and liver development in the ovine fetus during late gestation
We examined the effect of maternal chronic cold exposure, induced by winter-shearing ewes 4 weeks before their predicted lambing date, on brown adipose tissue (BAT) and liver development in lambs. Fetuses were sampled from under-fed (60% of energy requirements for maintenance and pregnancy of an uns...
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| Veröffentlicht in: | British journal of nutrition 1997-06, Vol.77 (6), p.871-883 |
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| creator | Clarke, Lynne Bryant, Michael J. Lomax, Michael A. Symonds, Michael E. |
| description | We examined the effect of maternal chronic cold exposure, induced by winter-shearing ewes 4 weeks before their predicted lambing date, on brown adipose tissue (BAT) and liver development in lambs. Fetuses were sampled from under-fed (60% of energy requirements for maintenance and pregnancy of an unshorn ewe) shorn or unshorn ewes at 126,140 and 145 d of gestation. Lambs were sampled from ewes within 2 h of birth. Throughout gestation fetal body, BAT and liver weights were similar in shorn and unshorn groups. The level of GDP binding to mitochondrial uncoupling protein remained low throughout gestation, but increased dramatically after birth. Lambs born to shorn ewes possesd more mitochondrial protein and exhibited a significantly higher total thermogenic activity in BAT. Type I iodothyronine 5 deiodinas(EC 3.8.1.4) activity in BAT peaked at birth, as did hepatic iodothyronine Sdeiodinase activity and was significantly greater in lambs born to under-fed shorn ewes, which exhibited a higher plasma triiodothyronine concentration. Chronic maternal adaptations to prolonged cold exposure appear to enable pregnant ewes to compensate for the negative effects of under-feeding on fetal growth and development |
| doi_str_mv | 10.1079/BJN19970086 |
| format | Article |
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Fetuses were sampled from under-fed (60% of energy requirements for maintenance and pregnancy of an unshorn ewe) shorn or unshorn ewes at 126,140 and 145 d of gestation. Lambs were sampled from ewes within 2 h of birth. Throughout gestation fetal body, BAT and liver weights were similar in shorn and unshorn groups. The level of GDP binding to mitochondrial uncoupling protein remained low throughout gestation, but increased dramatically after birth. Lambs born to shorn ewes possesd more mitochondrial protein and exhibited a significantly higher total thermogenic activity in BAT. Type I iodothyronine 5 deiodinas(EC 3.8.1.4) activity in BAT peaked at birth, as did hepatic iodothyronine Sdeiodinase activity and was significantly greater in lambs born to under-fed shorn ewes, which exhibited a higher plasma triiodothyronine concentration. Chronic maternal adaptations to prolonged cold exposure appear to enable pregnant ewes to compensate for the negative effects of under-feeding on fetal growth and development</description><identifier>ISSN: 0007-1145</identifier><identifier>EISSN: 1475-2662</identifier><identifier>DOI: 10.1079/BJN19970086</identifier><identifier>PMID: 9227185</identifier><identifier>CODEN: BJNUAV</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Adaptation, Physiological ; Adipose Tissue, Brown - embryology ; Adipose Tissue, Brown - metabolism ; Analysis of Variance ; Animal Nutrition ; Animals ; Biological and medical sciences ; Brown adipose tissue ; Cold Temperature ; Embryology: invertebrates and vertebrates. Teratology ; Embryonic and Fetal Development ; Epinephrine - metabolism ; Experimental organogenesis ; Female ; Fetus ; Fundamental and applied biological sciences. Psychology ; Gestational Age ; Iodide Peroxidase - metabolism ; Liver ; Liver - embryology ; Norepinephrine - metabolism ; Nutrition Disorders - metabolism ; Nutrition Disorders - veterinary ; Organogenesis. 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Fetuses were sampled from under-fed (60% of energy requirements for maintenance and pregnancy of an unshorn ewe) shorn or unshorn ewes at 126,140 and 145 d of gestation. Lambs were sampled from ewes within 2 h of birth. Throughout gestation fetal body, BAT and liver weights were similar in shorn and unshorn groups. The level of GDP binding to mitochondrial uncoupling protein remained low throughout gestation, but increased dramatically after birth. Lambs born to shorn ewes possesd more mitochondrial protein and exhibited a significantly higher total thermogenic activity in BAT. Type I iodothyronine 5 deiodinas(EC 3.8.1.4) activity in BAT peaked at birth, as did hepatic iodothyronine Sdeiodinase activity and was significantly greater in lambs born to under-fed shorn ewes, which exhibited a higher plasma triiodothyronine concentration. Chronic maternal adaptations to prolonged cold exposure appear to enable pregnant ewes to compensate for the negative effects of under-feeding on fetal growth and development</description><subject>Adaptation, Physiological</subject><subject>Adipose Tissue, Brown - embryology</subject><subject>Adipose Tissue, Brown - metabolism</subject><subject>Analysis of Variance</subject><subject>Animal Nutrition</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brown adipose tissue</subject><subject>Cold Temperature</subject><subject>Embryology: invertebrates and vertebrates. Teratology</subject><subject>Embryonic and Fetal Development</subject><subject>Epinephrine - metabolism</subject><subject>Experimental organogenesis</subject><subject>Female</subject><subject>Fetus</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gestational Age</subject><subject>Iodide Peroxidase - metabolism</subject><subject>Liver</subject><subject>Liver - embryology</subject><subject>Norepinephrine - metabolism</subject><subject>Nutrition Disorders - metabolism</subject><subject>Nutrition Disorders - veterinary</subject><subject>Organogenesis. Physiological fonctions</subject><subject>Pregnancy</subject><subject>Sheep</subject><subject>Sheep Diseases - metabolism</subject><subject>Triiodothyronine - blood</subject><issn>0007-1145</issn><issn>1475-2662</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkc1v1DAQxS0EKkvhxBnJB8QFBez4KznSii6gAkKCs-XYk8UlsYPtLPDf47KrVQ-crNH7zZuZZ4SeUvKKEtW_vvjwifa9IqST99CGciWaVsr2PtoQQlRDKRcP0aOcb2rZUdKfobO-bRXtxAZNH02BFMyEZxP8sk6m-BhwHPGQ4q-AjfNLzICLz3kFbILDk99Dwg72MMVlhlCwD7h8Bxz3PgAeoawZuzX5sMPVDvAOcvln-xg9GM2U4cnxPUffrt5-vXzXXH_evr98c91Y3srSdAwIMGflYHoyGmaJ49ANwgplwVonXCcMU47LjrOR10sEdxSg40PXstp6jl4cfJcUf651up59tjBNJkBcs1Y95awVtIIvD6BNMecEo16Sn036oynRt9nqO9lW-tnRdh1mcCf2GGbVnx91k62ZxmSC9fmEtYq0jKuKNQfM5wK_T7JJP7RUTAktt180kxdc0u2VvsNbMw_Jux3om7je_ln-75p_AZOwn5U</recordid><startdate>19970601</startdate><enddate>19970601</enddate><creator>Clarke, Lynne</creator><creator>Bryant, Michael J.</creator><creator>Lomax, Michael A.</creator><creator>Symonds, Michael E.</creator><general>Cambridge University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19970601</creationdate><title>Maternal manipulation of brown adipose tissue and liver development in the ovine fetus during late gestation</title><author>Clarke, Lynne ; Bryant, Michael J. ; Lomax, Michael A. ; Symonds, Michael E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c426t-83e0e3dc6ba90fa3c0d4e8b5c57ceccd5d85a37d46843f427154d1ee84b8230e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adaptation, Physiological</topic><topic>Adipose Tissue, Brown - embryology</topic><topic>Adipose Tissue, Brown - metabolism</topic><topic>Analysis of Variance</topic><topic>Animal Nutrition</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brown adipose tissue</topic><topic>Cold Temperature</topic><topic>Embryology: invertebrates and vertebrates. Teratology</topic><topic>Embryonic and Fetal Development</topic><topic>Epinephrine - metabolism</topic><topic>Experimental organogenesis</topic><topic>Female</topic><topic>Fetus</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gestational Age</topic><topic>Iodide Peroxidase - metabolism</topic><topic>Liver</topic><topic>Liver - embryology</topic><topic>Norepinephrine - metabolism</topic><topic>Nutrition Disorders - metabolism</topic><topic>Nutrition Disorders - veterinary</topic><topic>Organogenesis. Physiological fonctions</topic><topic>Pregnancy</topic><topic>Sheep</topic><topic>Sheep Diseases - metabolism</topic><topic>Triiodothyronine - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Clarke, Lynne</creatorcontrib><creatorcontrib>Bryant, Michael J.</creatorcontrib><creatorcontrib>Lomax, Michael A.</creatorcontrib><creatorcontrib>Symonds, Michael E.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Clarke, Lynne</au><au>Bryant, Michael J.</au><au>Lomax, Michael A.</au><au>Symonds, Michael E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Maternal manipulation of brown adipose tissue and liver development in the ovine fetus during late gestation</atitle><jtitle>British journal of nutrition</jtitle><addtitle>Br J Nutr</addtitle><date>1997-06-01</date><risdate>1997</risdate><volume>77</volume><issue>6</issue><spage>871</spage><epage>883</epage><pages>871-883</pages><issn>0007-1145</issn><eissn>1475-2662</eissn><coden>BJNUAV</coden><abstract>We examined the effect of maternal chronic cold exposure, induced by winter-shearing ewes 4 weeks before their predicted lambing date, on brown adipose tissue (BAT) and liver development in lambs. Fetuses were sampled from under-fed (60% of energy requirements for maintenance and pregnancy of an unshorn ewe) shorn or unshorn ewes at 126,140 and 145 d of gestation. Lambs were sampled from ewes within 2 h of birth. Throughout gestation fetal body, BAT and liver weights were similar in shorn and unshorn groups. The level of GDP binding to mitochondrial uncoupling protein remained low throughout gestation, but increased dramatically after birth. Lambs born to shorn ewes possesd more mitochondrial protein and exhibited a significantly higher total thermogenic activity in BAT. Type I iodothyronine 5 deiodinas(EC 3.8.1.4) activity in BAT peaked at birth, as did hepatic iodothyronine Sdeiodinase activity and was significantly greater in lambs born to under-fed shorn ewes, which exhibited a higher plasma triiodothyronine concentration. Chronic maternal adaptations to prolonged cold exposure appear to enable pregnant ewes to compensate for the negative effects of under-feeding on fetal growth and development</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>9227185</pmid><doi>10.1079/BJN19970086</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adaptation, Physiological Adipose Tissue, Brown - embryology Adipose Tissue, Brown - metabolism Analysis of Variance Animal Nutrition Animals Biological and medical sciences Brown adipose tissue Cold Temperature Embryology: invertebrates and vertebrates. Teratology Embryonic and Fetal Development Epinephrine - metabolism Experimental organogenesis Female Fetus Fundamental and applied biological sciences. Psychology Gestational Age Iodide Peroxidase - metabolism Liver Liver - embryology Norepinephrine - metabolism Nutrition Disorders - metabolism Nutrition Disorders - veterinary Organogenesis. Physiological fonctions Pregnancy Sheep Sheep Diseases - metabolism Triiodothyronine - blood |
| title | Maternal manipulation of brown adipose tissue and liver development in the ovine fetus during late gestation |
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