Elastin degradation products induce adventitial angiogenesis in the Anidjar/Dobrin rat aneurysm model

Background. Infusion of the abdominal aorta with pancreatic elastase induces aneurysms in a rat model (Anidjar/Dobrin). Because elastolysis liberates elastin degradation products (EDPs), the present experiment was carried out to test the hypothesis that an EDP alone could induce features of aneurysm...

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Veröffentlicht in:	Surgery 1997-07, Vol.122 (1), p.39-44
Hauptverfasser:	Nackman, Gary B, Karkowski, Fredrick J, Halpern, Vivian J, Gaetz, Harold P, Tilson, M.David
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aortic Aneurysm, Abdominal - metabolism Aortic Aneurysm, Abdominal - pathology Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Disease Models, Animal Diseases of the aorta Elastin - metabolism Elastin - pharmacology Medical sciences Muscle, Smooth, Vascular - metabolism Neovascularization, Pathologic - chemically induced Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - physiopathology Oligopeptides - pharmacology Rats Rats, Wistar
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